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Multiple sclerosis research in Europe

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452 pages
Proceedings of a conference held at Nijmegen (NL) on January 29-31 1985
Medical and biological research
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About the Book
This book contains the written texts of
presentations at a conference sponsored
by the Commission of the European
Communities on Multiple Sclerosis
Research in Europe, held in Nijmegen,
The Netherlands, January 1985.
About the Editor
Professor Otto R. Hommes spends most
of his professional life as a neurologist
working on treatment and research in
multiple sclerosis.
He is a clinical neurologist and Head of
the Department of Experimental
Neurology at the Institute of Neurology,
St. Radboud University Hospital,
Catholic University, Nijmegen, The
Netherlands. Multiple Sclerosis Research
in Europe COMMISSION OF THE EUROPEAN COMMUNITIES
MULTIPLE
SCLEROSIS
RESEARCH IN
EUROPE
Report of a Conference on Multiple Sclerosis Research in
Europe, January 29th—31st 1985, Nijmegen,
The Netherlands.
Sponsored by the Commission of the
European Communities, as advised by the
Committee on Medical Public Health Research
ΛΛΛΛ^ ν Γ*Ar. < „ ^ / () L/
Editor
Otto R. Homme sPARL.EUROP.Eibiioth.
M. C. \
\i\-~^EUR f0.3tzs\
MTP PRESS LIMITED LJ
a member of the KLUWER ACADEMIC PUBLISHERS GROUP |~
LANCASTER / BOSTON / THE HAGUE / DORDRECHT I
for the Commission of the European Communities Published in the UK and Europe by
MTP Press Limited
Falcon House
Lancaster, England
British Library Cataloguing in Publication Data
Multiple sclerosis research in Europe: report of
a CEC Conference Nijmegen 29, 30, 31 January 1985.
1. Multiple sclerosis—Research—Europe
I. Hommes, Otto R. II. Commission of the
European Communities
616.8'34'007204 RC377
ISBN 0-85200-917-8
Published in the USA by
MTP Press
A division of Kluwer Boston Inc
1 90 Old Derby Street
Hingham, MA 02043, USA
Library of Congress Cataloging in Publication Data
Hommes, Otto R. (Otto Roelf)
Multiple sclerosis research in Europe.
At head of title: MSRE.
Report to the Commission of the European Communities
of a Conference on Multiple Sclerosis Research in Europe.
Includes bibliographies and index.
1. Multiple sclerosis—Research—Europe—Congresses.
2.e sclerosis—Congresses. 3. Conference on
Multiple Sclerosis Research in Europe (1985 : Nijmegen,
Netherlands) I. Commission of the European Communities.
II. Title. III. Title: MSRE. [DNLM: 1. Conference on
Multiple Sclerosis Research in Europe (1985 : Nijmegen,
Netherlands) 2. Multiple Sclerosis—occurrence—Europe.
WL360H768m 19851
RC377.H66 1985 616.8'34'007204 85-24053
ISBN 0-85200-917-8
© ECSC, EEC, EAEC, Brussels and Luxembourg, 1 986
EUR 10312 EN
Legal Notice
Neither the Commission of the European Communities nor any person acting on behalf of the
Commission is responsible for the use which might be made of the following information.
Publication arranged by
Commission of the European Communities
Directorate-General Information Market and Innovation-
Scientific and Technical Communication
Brussels and Luxembourg.
All right reserved. No part of this publication may be reproduced, stored in a retrieval system, or
transmitted in any form or by any means, electronic, mechanical, photocopying, recording or otherwise,
without prior permission from the publishers.
Printed and Bound by Butler and Tanner Ltd, Frome and London Contents
Introduction x¡
Programme of the Conferencev
List of Participants and Observers xx
SECTION I CLINICAL STUDIES
1 Clinical Studies in Multiple Sclerosis
5. Poser 3
2 Clinical Trials
P. Rudge 13
3 Onset, Course and Prognosis of Multiple Sclerosis
C. Confavreux 5
4 A Comparative Study Between Multiple Sclerosis Out-patients and
In-patients Staying at a Specialized Multiple Sclerosis Clinic
R. Medaer, M. Puystjens and H. Callaert 31
5 Incapacity and Disability in Multiple Sclerosis
]. M. Minderhoud, A. J. A. Prange and H. Dassel 41
6 Immunosuppression with Cyclophosphamide in Multiple Sclerosis
Patients
R. E. Consecce and L Demoncy 45 vi CONTENTS
7 Anti-lymphocyte Serum in Severe Multiple Sclerosis
R. Marteau, F. Lhermitte and H. de Saxce 49
8 Long-term Prescription of Azathioprine in Multiple Sclerosis.
A Review of Published Series
O. Sabouraud and M. Mérienne 5 5
9 Azathioprine Assessment in Progressive Multiple Sclerosis.
Clinical Aspects
/. E. leeberg 61
10 Dietary Therapy in Multiple Sclerosis
D. Bates 7
11 An Eight Years Follow-up Study of Transfer Factor Treatment on the
Course of Multiple Sclerosis
A. M. Norden bo and I. Zeeberg 8
12 Compact Manual for Multiple Sclerosis Registration in Clinical
Research
O. Andersen, M. Andersson, T. Broman and I. Zeeberg 85
13 Comparison of Multiple Sclerosis Incidence Clinical and ABR Data
Indicates a Higher Degree of Dissemination of Lesions in a
Progressive than in a Remitting Course
O. Andersen, il. Rosenhall and B. Runmarker 95
SECTION II IMMUNOLOGY
14 Multiple Sclerosis and Immunity: Facts, Fiction and Future
Development
7. Mertin 103
1 5 The Spectrum of Experimental Allergic Encephalomyelitis
H. Lassmann and K. Vass9
1 6 T Cell Subsets in Multiple Sclerosis
M. A. Bach and E. Tournier-Lasserve 115
1 7 Functional Differences Between Cerebrospinal Fluid and Peripheral
Blood T Cells in Multiple Sclerosis
M. 5. Wollheim and E. C. DeFreitas 123