Comparison of health-related quality of life measures in chronic obstructive pulmonary disease
6 pages
English

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Comparison of health-related quality of life measures in chronic obstructive pulmonary disease

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6 pages
English
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The aims of this study were: (1) to compare the discriminative ability of a disease-specific instrument, the St. George's Respiratory Questionnaire (SGRQ) to generic instruments (i.e., EQ-5D and SF-36); and (2), to evaluate the strength of associations among clinical and health-related quality of life (HRQL) measures in chronic obstructive pulmonary disease (COPD). Methods We analyzed data collected from 120 COPD patients in a Veterans Affairs hospital. Patients self-completed two generic HRQL measures (EQ-5D and SF-36) and the disease-specific SGRQ. The ability of the summary scores of these HRQL measures to discriminate COPD disease severity based on Global Obstructive Lung Disease (GOLD) stage was assessed using relative efficiency ratios (REs). Strength of correlation was used to further evaluate associations between clinical and HRQL measures. Results Mean total scores for PCS-36, EQ-VAS and SGRQ were significantly lower for the more severe stages of COPD ( p < 0.05). Using SGRQ total score as reference, the summary scores of the generic measures (PCS-36, MCS-36, EQ index, and EQ-VAS) all had REs of <1. SGRQ exhibited a stronger correlation with clinical measures than the generic summary scores. For instance, SGRQ was moderately correlated with FEV 1 ( r = 0.43), while generic summary scores had trivial levels of correlation with FEV 1 ( r < 0.2). Conclusions The SGRQ demonstrated greater ability to discriminate among different levels of severity stages of COPD than generic measures of health, suggestive that SGRQ may provide COPD studies with greater statistical power than EQ-5D and SF-36 summary scores to capture meaningful differences in clinical severity.

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Publié le 01 janvier 2011
Nombre de lectures 8
Langue English

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Pickardet al.Health and Quality of Life Outcomes2011,9:26 http://www.hqlo.com/content/9/1/26
R E S E A R C HOpen Access Comparison of healthrelated quality of life measures in chronic obstructive pulmonary disease 1* 11,2 A Simon Pickard, Yoojung Yangand Todd A Lee
Abstract Background:The aims of this study were: (1) to compare the discriminative ability of a diseasespecific instrument, the St. Georges Respiratory Questionnaire (SGRQ) to generic instruments (i.e., EQ5D and SF36); and (2), to evaluate the strength of associations among clinical and healthrelated quality of life (HRQL) measures in chronic obstructive pulmonary disease (COPD). Methods:We analyzed data collected from 120 COPD patients in a Veterans Affairs hospital. Patients self completed two generic HRQL measures (EQ5D and SF36) and the diseasespecific SGRQ. The ability of the summary scores of these HRQL measures to discriminate COPD disease severity based on Global Obstructive Lung Disease (GOLD) stage was assessed using relative efficiency ratios (REs). Strength of correlation was used to further evaluate associations between clinical and HRQL measures. Results:Mean total scores for PCS36, EQVAS and SGRQ were significantly lower for the more severe stages of COPD (p< 0.05). Using SGRQ total score as reference, the summary scores of the generic measures (PCS36, MCS36, EQ index, and EQVAS) all had REs of <1. SGRQ exhibited a stronger correlation with clinical measures than the generic summary scores. For instance, SGRQ was moderately correlated with FEV1(r= 0.43), while generic summary scores had trivial levels of correlation with FEV1(r< 0.2). Conclusions:The SGRQ demonstrated greater ability to discriminate among different levels of severity stages of COPD than generic measures of health, suggestive that SGRQ may provide COPD studies with greater statistical power than EQ5D and SF36 summary scores to capture meaningful differences in clinical severity. Keywords:respiratory disease quality of life, COPD, health status, EQ5D
Background Chronic obstructive pulmonary disease (COPD) is a leading cause of death worldwide and is associated with a high burden of illness [1], particularly in terms of healthrelated quality of life (HRQL). COPD is charac terized by airflow obstruction that is not fully reversible and symptoms such as dyspnea, sputum production, and chronic cough [2]. Airflow limitation is usually progres sive; thus daily activities can become very difficult as the condition gradually worsens. Consequently, the burden
* Correspondence: pickard1@uic.edu 1 Center for Pharmacoeconomic Research and Department of Pharmacy Practice, University of Illinois at Chicago, Chicago, IL, 60612, USA Full list of author information is available at the end of the article
of COPD on HRQL disease tends to increase with COPD severity [36]. HRQL is inherently subjective, involving patient self assessment of multiple dimensions of health that often are not strongly correlated with clinical indicators of COPD [7,8]. Measures of selfreported HRQL and pul monary function assess different aspects of the disease and therefore provide complementary information [9,10]. Both generic and diseasespecific HRQL instru ments are used in COPD. St. Georges Respiratory Questionnaire (SGRQ) is a diseasespecific measure used in both COPD and asthma research [11]. EQ5D [12] and the SF36 [13] are generic measures of health often used in studies of COPD [3,5,10,14,15].
© 2011 Pickard et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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