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Cancer Cytogenetics

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752 pages
The preeminent book on cancer cytogenetics—now in a valuable new edition

Like its successful predecessors, Cancer Cytogenetics, Third Edition continues to offer authoritative coverage of neoplastic processes at the chromosomal level of genomic organization. Now updated and expanded, this new edition includes detailed information on the most recent advances in the field, incorporating a vast amount of new cytogenetic as well as molecular genetic data from the latest basic and clinical investigations.

Edited by two leading authorities, who are now aided by a panel of internationalexperts, this new edition has been updated to include:

  • Greatly expanded coverage of solid tumors
  • Enhanced coverage of acute and chronic myeloproliferative disorders

  • The latest findings on acute and chronic lymphoproliferative disorders

Cancer Cytogenetics, Third Edition is a valuable resource for researchers in a wide range of fields, including cytogenetics, medical and molecular genetics, cellular and molecular biology, oncology, and hematology. With its complete coverage of thecytogenetic mechanisms underlying neoplasia, and always with a keen eye on the clinical consequences of the various acquired genetic aberrations, this text will alsobe an indispensable reference for all clinicians involved in the diagnosis and treatment of cancer patients.

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Preface vii
Contributors ix
1. A New Approach to an Old Problem 1
Sverre Heim and Felix Mitelman
2. Cytogenetic Methods 9
David Gisselsson
3. Cytogenetic Nomenclature 17
Sverre Heim and Felix Mitelman
4. Nonrandom Chromosome Abnormalities in Cancer—An Overview 25
Sverre Heim and Felix Mitelman
5. Acute Myeloid Leukemia 45
Bertil Johansson and Christine J. Harrison
6. Myelodysplastic Syndromes 141
Harold J. Olney and Michelle M. Le Beau
7. Chronic Myeloid Leukemia 179
Thoas Fioretos and Bertil Johansson
8. Chronic Myeloproliferative Neoplasms 209
Peter Vandenberghe, Lucienne Michaux, and Anne Hagemeijer
9. Acute Lymphoblastic Leukemia 233
Christine J. Harrison and Bertil Johansson
10. Mature B- and T-Cell Neoplasms and Hodgkin Lymphoma 297
Reiner Siebert
11. Tumors of the Upper Aerodigestive Tract 375
Mihaela Avramut and Susanne M. Gollin
12. Tumors of the Lung 415
Penny Nymark, Eeva Kettunen, and Sakari Knuutila
13. Tumors of the Digestive Tract 429
Georgia Bardi and Sverre Heim
14. Tumors of the Urinary Tract 463
Paola Dal Cin and Azra H. Ligon
15. Tumors of the Breast 493
Manuel R. Teixeira, Nikos Pandis, and Sverre Heim
16. Tumors of the Female Genital Organs 519
Francesca Micci and Sverre Heim
17. Tumors of the Male Genital Organs 557
Manuel R. Teixeira and Sverre Heim
18. Tumors of Endocrine Glands 577
Jorn Bullerdiek and David Gisselsson
19. Tumors of the Nervous System 597
Aaron M. Bender, Fausto J. Rodriguez, Gobinda Sarkar, and Robert B. Jenkins
20. Tumors of the Eye 621
Karen Sisley
21. Tumors of the Skin 641
Fredrik Mertens and Sverre Heim
22. Tumors of Bone 655
Fredrik Mertens and Nils Mandahl
23. Soft Tissue Tumors 675
Nils Mandahl and Fredrik Mertens
Index 713