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Basic Virology

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584 pages
Ideal for the student seeking a solid understanding of the basic principles in this rapidly developing field, this best-selling text offers a comprehensive introduction to the fundamentals of virology. Featuring an enhanced art program now in full-color, the new edition has been updated throughout.

  • New edition incorporates additional reading suggestions, expanded review questions, chapter outlines and full-colour artwork

  • Contains new chapters dealing with viruses and cancer, generation and use of recombinant viruses and virus-like particles, viral evolution, network biology and viruses, and animal models and transgenics, as well as a chapter devoted to HIV and AIDS

  • Downloadable artwork, original animations and online resources are available at www.blackwellpublishing.com/wagner
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Brief Contents
Preface xxi Acknowledgments xxix
PART I
Chapter 1 Chapter 2 Chapter 3 Chapter 4
VI ROLOGY AND VI RAL DI SEASE
1
Introduction – The Impact of Viruses on Our View of Life 3 An Outline of Virus Replication and Viral Pathogenesis 15 Virus Disease in Populations and Individual Animals 27 Patterns of Some Viral Diseases of Humans 41
PART I I BASI C PROPERTI ES OF VI RUSES AND VI RUS– CELL I NTERACTI ON 63
Chapter 5 Chapter 6 Chapter 7
Chapter 8
Virus Structure and Classification 65 The Beginning and End of the Virus Replication Cycle 79 HostImmuneResponsetoViralInfectionTheNatureoftheVertebrate Immune Response 97 Strategies to Protect Against and Combat Viral Infection 119
PART I I I
Chapter 9 Chapter 10 Chapter 11 Chapter 12 Chapter 13
WORKI NG WI TH VI RUS
145
Visualization and Enumeration of Virus Particles 147 Replicating and Measuring Biological Activity of Viruses 155 Physical and Chemical Manipulation of the Structural Components of  Viruses 173 Characterization of Viral Products Expressed in the Infected Cell 193 VirusesUseCellularProcessestoExpresstheirGenetic Information 213
PART I V VI RUSES
REPLI CATI ON PATTERNS OF SPECI FI C 243
Chapter 14 Replication of Positivesense RNA Viruses 245 Chapter 15 Replication Strategies of RNA Viruses Requiring RNAdirected mRNA  Transcription as the First Step in Viral Gene Expression 273 Chapter 16 Replication Strategies of Small and Mediumsized DNA Viruses 303
vi
BRIEFCONTENTS
Chapter 17 Chapter 18 Chapter 19 Chapter 20 Chapter 21
Replication of Some Nuclearreplicating Eukaryotic DNA Viruses with  Large Genomes 331 Replication of Cytoplasmic DNA Viruses and “Large” Bacteriophages 359 Retroviruses: Converting RNA to DNA 381 HumanImmunodeciencyVirusType1(HIV1)andRelatedLentiviruses 399 Hepadnaviruses: Variations on the Retrovirus Theme 413
PART V VI RUSES: NEW APPROACHES AND NEW PROBLEMS 433
Chapter 22 Chapter 23 Chapter 24 Chapter 25
The Molecular Genetics of Viruses 435 Molecular Pathogenesis 463 Viral Bioinformatics and Beyond 473 Viruses and the Future – Problems and Promises 485
Appendix Resource Center 501 Technical Glossary 507 Index 533