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AIDS in Africa : Second Edition

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This comprehensive reference book addresses the unique challenges facing many African nations as poor infrastructure and economics continue to obstruct access to advanced treatments and AIDS care training. While it takes into account the context of settings with limited resources, it also looks ahead to how many African nations are successfully increasing their capacity to serve those affected by HIV and AIDS. Information on how to best utilize existing resources and prioritize scaling-up of infrastructure is a critical aspect of this book for those working in HIV/AIDS-related fields in Africa.

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Table of Contents
I: PATHOGENESIS
Introduction: The Etiology of AIDS Max Essex and Souleymane Mboup
The Molecular Virology of HIV1 Monty Montana and Carolyn Williamson
Immunopathogenesis of AIDS Lynn Zijenah and David A. Katzenstein
Effect of Genetic Variation on HIV Transmission and Progression to AIDS Cheryl A. Winkler and Stephen J. O’Brien
Biology of Human Immunodeficiency Virus Type 2 (HIV2) Phyllis J. Kanki, JeanLouis Sankalé, and Souleymane Mboup
Simian Immunodeficiency Viruses and the Origin of HIVs Ousmane M. Diop, Aïssatou Guèye, Ahidjo Ayouba, Eric Nerrienet, Sylvie Corbet, Philippe Mauclère, François Simon, Françoise BarréSinoussi, and Michaela C, MüllerTrutwin
II: DETECTION AND MONITORING OF HIV INFECTION AND DISEASE
Serodiagnosis of HIV Infection Aissatou GuèyeNdiaye
Molecular Diagnosis of HIV Infection Boris Renjifo
Monitoring HIV1 Subtype Distribution Francis R. Barin, Coumba ToureKane, JeanChristophe Plantier, and Martine Peeters
Monitoring Viral Load Phyllis J. Kanki and Indu Mani
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TABLE OF CONTENTS
Monitoring Immune Function Gunnel Biberfeld and Eligius Lyamuya
III: EPIDEMIOLOGY
The Epidemiology of HIV and AIDS Peter Piot and Michael Bartos
Transmission of HIV Sibylle Kristensen, Moses Sinkala, and Sten H. Vermund
Role of Sexually Transmitted Diseases in HIVTransmission Saidi H. Kapiga and Iain W. Aitken
MothertoChild Transmission of HIV Anne Willoughby
HIV1 Subtypes and Recombinants Boris Renjifo and Max Essex
Current Estimates and Projections for the Epidemic Karen A. Stanecki and Neff Walker
IV: CLINICAL SPECTRUM AND TREATMENT OF HIVRELATED DISEASES
Clinical Diagnosis of AIDS and HIVRelated Diseases Churchill Lukwiya Onen
Antiretroviral Therapy in ResourceLimited Settings Anthony Amoroso, Charles E. Davis, and Robert R. Redfield
HIV1 Drug Resistance Mark A. Wainberg and Bluma G. Brenner
Opportunistic Infections Robert Colebunders, Patrick K. Kayembe, and Ann Marie Nelson
Tuberculosis Renée Ridzon and Harriet MayangaKizza
HIV Infection and Cancer Robert Newton, Freddy Sitas, Martin Dedicoat, and John L. Ziegler
Challenges and Opportunities for Nurses Sheila D. Tlou
HomeBased Care Quarraisha Abdool Karim, Samuel Kalibala, Elly T. Katabira, and Zena A. Stein
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TABLE OF CONTENTS
Nutrition and HIV Infection Annamaria K. Kiure, GernardI. Msamanga, and Wafaie W. Fawzi
Access to HIV and AIDS Care Kirthana Ramanathan, Daniel Tarantola, and Richard G. Marlink
V: PEDIATRIC HIV INFECTION AND DISEASE
Diagnosis of Pediatric HIV Infection Chewe Luo and Brian Coulter
Treatment of HIV in Children Using Antiretroviral Drugs Gabriel M. Anabwani and Mark W. Kline
Pediatric Opportunistic Infections Shahin Lockman and Kenneth McIntosh
VI: PREVENTION OF HIV INFECTION
Male Condoms and Circumcision Roger L. Shapiro and Saidi H. Kapiga
Female Condoms and Microbicides Eka EsuWilliams and Kelly Blanchard
Behavioral Change: Goals and Means Poloko Kebaabetswe and Kathleen F. Norr
Voluntary Counseling and Testing Elizabeth Marum, Carl H. Campbell, Katawa Msowoya, Augustine Barnaba, and Beth Dillon
Prevention of Perinatal Transmission of HIV Sophie Le Coeur and Marc Lallemant
Prevention of Breast Milk Transmission of HIV: Balancing the Benefits and the Risks Ruth Nduati and Dorothy MboriNgacha
Postexposure Prophylaxis for Occupational Exposure and Sexual Assault Elisabeth Bouvet, Anne Laporte, and Arnaud Tarantola
VII: VACCINE DEVELOPMENT
The Need for a Vaccine Seth Berkley
HIV Vaccines: Design and Development TunHou Lee and Vlad Novitsky
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HIV1 Vaccine Testing, Trial Design, and Ethics Peter B. Gilbert and José Esparza
VIII: IMPACT AND RESPONSE
Regional Variations in the African Epidemics Max Essex and Souleymane Mboup
Human Rights and HIV/AIDS Sofia Gruskin and Miriam Maluwa
Gender and HIV/AIDS Sheila D. Tlou
The Orphan Crisis Geoff Foster and Stefan
Germann
The Economics of AIDS in Africa Amar A. Hamoudi and Jeffrey D. Sachs
International Cooperation and Mobilization Keith E. Hansen and Debrework Zewdie
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