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Publié par | friedrich-schiller-universitat_jena |
Publié le | 01 janvier 2012 |
Nombre de lectures | 54 |
Poids de l'ouvrage | 19 Mo |
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Strategies against acid induced hydroxyapatite
dissolution of human dental enamel
Dissertation
zur Erlangung des akademischen Grades
doctor rerum naturalium (Dr. rer. nat.)
vorgelegt dem Rat der Biologisch‐Pharmazeutischen Fakultät
der Friedrich‐Schiller‐Universität Jena
von Dipl.‐Troph. Markus Beyer
geboren am 15.11.1981 in Jena
Gutachter:
1 Prof. Dr. Gerhard Jahreis
Friedrich‐Schiller University Jena, Germany
2 Prof. Dr. Klaus D. Jandt
Friedrich‐Schiller University Jena, Germany
3 Dr. Nick Silikas
School of Dentistry, The University of Manchester, United Kingdom
Tag der Disputation: 21.11.2011
2
INDEX OF CONTENTS
INDEX OF CONTENT
INDEX OF CONTENT .......................................................................................................... 3
ABBREVIATIONS .............................................................................................................. 5
MOTIVATION ................................................................................................................. 6
1 INTRODUCTION ........................................................................................................ 7
1.1 Macro and micro anatomy of teeth and composition of
human dental enamel ............................................................................... 7
1.2 Definition, mechanism and pathology of human dental
enamel erosion ........................................................................................ 12
1.3 Strategies against human dental enamel erosion .................................. 16
1.4 Aims and Objectives ................................................................................ 17
2 OVERVIEW OF MANUSCRIPTS .................................................................................... 19
3 MANUSCRIPTS ....................................................................................................... 23
3.1 Manuscript I (published) ......................................................................... 23
Quantification of dental erosion ‐ A comparison of stylus
profilometry and confocal laser scanning microscopy (CLSM)
Erik Heurich, Markus Beyer, Klaus D. Jandt, Joerg Reichert,
Volker Herold, Matthias Schnabelrauch, Bernd W. Sigusch
Dental Materials 2010; 26 (4): 326‐336
3.2 Manuscript II (published) ........................................................................ 35
Pectin, alginate and gum arabic polymers reduce citric acid
erosion effects on human enamel
Markus Beyer, Jörg Reichert, Erik Heurich, Klaus D. Jandt,
Bernd W. Sigusch
Dental Materials 2010; 26 (9): 831‐839
3.3 Manuscript III (in preparation) ................................................................ 45
Morphology and structure of polymer layers protecting
dental enamel against erosion
Markus Beyer, Jörg Reichert, Bernd W. Sigusch, David C. Watts,
Klaus D. Jandt
3
INDEX OF CONTENTS
3.4 Manuscript IV (published) ....................................................................... 68
Acids with an equivalent taste lead to different erosion
of human dental enamel
Markus Beyer, Jörg Reichert, Jörg Bossert, Bernd W. Sigusch,
David C. Watts, Klaus D. Jandt
Dental Materials 2011; 27 (10): 1017‐1023
4 FINAL DISCUSSION .................................................................................................. 76
4.1 Measurement methods used to characterise human dental
erosion ..................................................................................................... 76
4.2 The protective effect of polymers added to citric acid solutions
against the process of human dental erosion ......................................... 79
4.3 Insights into the polymer‐enamel interaction during the process
of erosion ................................................................................................ 85
4.4 Human dental erosion caused by different acids with an identical
sensorial taste ......................................................................................... 91
4.5 Conclusions.............................................................................................. 93
5 SUMMARY ............................................................................................................ 95
6 ZUSAMMENFASSUNG 98
REFERENCES ............................................................................................................... 101
SELBSTSTÄNDIGKEITSERKLÄRUNG ................................................................................... 113
CURRICULUM VITAE ..................................................................................................... 113
LIST OF PUBLICATIONS, POSTERS AND ORAL PRESENTATIONS ............................................... 115
DANKSAGUNG ............................................................................................................ 118
4
ABBREVIATIONS
ABBREVIATIONS
AA ascorbic acid
AFM atomic force microscopy
CA citric acid
CAS citric acid solution
CLSM confocal laser scanning microscopy
EU European Union
GA gum arabic
HA hydroxyapatite (also used for human enamel)
HP highly esterified pectin
INS International numbering system (E‐number = European classification)
LA lactic acid
LP low esterified pectin
MA malic acid
Na‐CMC Na‐carboxymethyl cellulose
NI nanoindentation
PA phosphoric acid
PGA propylene glycol alginate
PMCAS polymer modified citric acid solution
SEM scanning electron microscopy
TA tartaric acid
wt weight
XPS X‐ray photoelectron spectroscopy
5
MOTIVATION
MOTIVATION
The lifestyle and the quality of life of industrialized western countries have reached a
high standard. The most obvious standards are the personal lifestyle, as well as a
health‐oriented perspective in terms of physical fitness and nutrition. Besides healthy
mental and physical condition also adequate external representation plays an
important role in life. In addition to these personal goals in life there are more and
more aesthetic aspects important today. This is reflected in a fresh outlook as well