Treating Premature Ejaculation: Dapoxetine Hydrochloride Powder

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Description

http://www.aasraw.com/products/dapoxetine-hydrochloride/ - Dapoxetine hydrochloride powder also write as  dapoxetine HCL powder, it is hydrochloride type of dapoxetine. is white crystaline powder.

Informations

• Publié par: seorumer
• Publié le: 19 avril 2018
• Nombre de lectures: 8
• Langue: English

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Treating Premature Ejaculation : Dapoxetine hydrochloride powder

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Content

1. What is Dapoxetine hydrodhloride powder? ........................................ 1

2. How does Dapoxetine hydrochloride work?......................................... 5

3. Dapoxetine hydrochloride other name................................................. 6

4. What is Dapoxetine hydrochloride use for? ......................................... 6

5. What is Premature Ejaculation(PE)? ..................................................... 7

6. How to use Dapoxetine hydrochloride powder丨8Dapoxetine dosage

7. Dapoxetine hydrochloride effects? ..................................................... 10

8. Dapoxetine VS Tadalafil ...................................................................... 12

9. Is it safe to take dapoxetine hydrochloride?....................................... 15

10. Dapoxetine side effects..................................................................... 18

11. Buy Dapoxetine hydrochloride powder ............................................ 19

1. What is Dapoxetine hydrodhloride powder?

Dapoxetine hydrochloride powder also write asdapoxetine HCL powder, it

is hydrochloride type of dapoxetine. Dapoxetine hydrochloride powder is

Treating Premature Ejaculation : Dapoxetine hydrochloride powder

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white crystaline powder, CAS No. is 129938-20-1. Dapoxetine HCL powder

is a new antidepressant, has been found to be safe and effective for the

treatment of premature ejaculation, according to two major clinical trials.

Dapoxetin is a short-acting selective serotonin reuptake inhibitor (SSRI). It is

not uncommon for SSRIs to be used off-label for premature ejaculation.

Premature ejaculation(PE) is the most common male sexual dysfunction with

a prevalence of between 20% and 40%. Recently, the International Society for

Sexual Medicine has proposed the following evidence-based definition:“PE is

a male sexual dysfunction characterized by ejaculation that always or nearly

always occurs prior to or within about 1 minute of vaginal penetration;

inability to delay ejaculation on all or nearly all vaginal penetrations; and

negative personal consequences, such as distress, bother, frustration, and/or

the avoidance of sexual intimacy". In addition, PE affects numerous aspects of

a man's life, including sexual confidence, interpersonal relationships, and the

sexual satisfaction of both partners. The role of PE on the individual and the

sexual relationship is very significant. Thus, it is important to treat patients

with Premature ejaculation(PE) in order to improve quality of life. At present,

Treating Premature Ejaculation : Dapoxetine hydrochloride powder

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treatment of PE includes mainly psychotherapy, drug therapy, and surgical

treatment6.

Drug therapy is not only likely to be the most receptive approach for patients,

but it is also the most commonly used method. Selective serotonin reuptake

inhibitors (SSRIs) have become the most widely used medicine in the world.

Dapoxetine hydrochloride, belonging to the class of SSRIs, was the first drug

originally approved for the on-demand treatment of men with PE by seven

European countries in 2008.

Name

CAS

Molecular Formula

Molecular Weight

Melt Point

Storage Temp

Color

Decription

Dapoxetine powder description

Dapoxetine hydrochloride, Dapoxetine hydrochloride

129938-20-1

C9H7ClN2O5

258.62

175-179°C

-20°C Freezer

White crystalline powder

Dapoxetine HCL is a short-acting novel selective serotonin reuptake inhibitor, used for the treatment of premature ejaculation.Dapoxetine not only reduces the peak amplitude of Kv4.3 currents but also accelerates the decay rate of current inactivation in a concentration-dependent manner. Dapoxetine decreases the integral of the Kv4.3 currents over the duration of a depolarizing pulse with an IC50 of 5.3 μM. Dapoxetine also causes a substantial acceleration in

Treating Premature Ejaculation : Dapoxetine hydrochloride powder

[e-mail], Whatsapp:[phone] closed-state inactivation. Dapoxetine produces a significant use-dependent block, which is accompanied by a delayed recovery from inactivation of Kv4.3

Package method

Delivery method

Guarantee period

Delivery time

Payment mtehod

Picture

currents. Dapoxetine decreases the peak amplitude of

Kv1.5 currents and accelerates the decay rate of current

inactivation in a concentration-dependent manner with

an IC50 of 11.6 μM. Dapoxetine decreases the tail

current amplitude and slows the deactivation process

of Kv1.5, which results in a tail crossover phenomenon. Dapoxetine produces a use-dependent block of Kv1.5 at frequencies of 1 and 2 Hz and slowed the time

course for recovery of inactivation.Dapoxetine also

appears to be a useful adjunct to morphine, lowering the threshold for analgesia, although Dapoxetine itself has negligible analgesic activity. Dapoxetine is the

D-enantiomer of LY 243917 and is 3.5 times more potent as a serotonin reuptake inhibitor than the L-enantiomer

foil bag or customization

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around 3years under the correct storage condition

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Treating Premature Ejaculation : Dapoxetine hydrochloride powder

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2. How does Dapoxetine hydrochloride work?

Dapoxetine mechanism of action? The mechanism through which dapoxetine

affects premature ejaculation is still unclear. However, it is presumed that

dapoxetine works by inhibiting serotonin transporter and subsequently

increasing serotonin's action at pre and postsynaptic receptors Human

ejaculation is regulated by various areas in the central nervous system

(CNS).The ejaculatory pathway originates from spinal reflex at the

thoracolumbar and lumbosacral level of spinal cord activated by stimuli from

male genital. These signals are relayed to the brain stem, which then is

influenced by a number of nuclei in the brain such as medial preoptic and

paraventricular nulcei.Clement's study performed on anaesthetized male rats

showed that acute administration of dapoxetine inhibits ejaculatory

expulsion reflex at supraspinal level by modulating activity of lateral

paragigantocellular nucleus (LPGi) neurons. These effects cause an increase in

pudendal motoneuron reflex discharge (PMRD) latency. However, it is unclear

whether dapoxetine acts directly on LPGi or on the descending pathway in

which LPGi located.

Treating Premature Ejaculation : Dapoxetine hydrochloride powder

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3. Dapoxetine hydrochloride other name

Dapoxetine hydrochloride/Dapoxetine HCL marketed as Priligy and

Westoxetin, among and other brands.

4. What is Dapoxetine hydrochloride use for?

Dapoxetine hydrochloride powder/Dapoxetine HCL powder use for treat

premature ejaculation in men aged 18 to 64 years.

Priligy tablets contain the active ingredient raw dapoxetine hydrochloride

powder, which is a type of medicine known as a selective serotonin reuptake

inhibitor. It is used to treat premature ejaculation in men.

Raw dapoxetine hydrochloride powderworks by increasing the activity of

serotonin in the nervous system. Serotonin is a neurotransmitter that is

involved in passing messages between nerve cells. It has various functions in

the body and is involved in sending the nerve messages that result in

ejaculation. Increasing the activity of serotonin in the nervous system helps to

increase the time it takes to ejaculate and improve control over the

ejaculation.The medicine is taken a couple of hours before you intend to have

sex to help you last longer before you climax.

Treating Premature Ejaculation : Dapoxetine hydrochloride powder

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The research team examined the results of two trials, totalling 2,614 men. All

the men had from moderate to severe premature ejaculation - on average,

the men were ejaculating within one minute of penetration. Half of them

were randomly selected to receive Dapoxetine while the other half received a

placebo. Both groups had to take their medication from 1 to 3 hours before

sexual intercourse.

After three months, the men taking a 30-milligram dose of dapoxetine took

an average 2.78 minutes to ejaculate after penetration, those on a

60-milligram dose took 3.32 minutes. The placebo group averaged 1.75

minutes (after three months).

5. What is Premature Ejaculation(PE)?

In lay terms it means 'coming too quickly' (for a man). The man ejaculates

sooner than he or his partner would like. It is common for this to happen now

and again. It is seen as a problem for many men and some of their partners

if this happens regularly. It is the most common male sexual dysfuntion -

estimated to affect about 20% of males in the USA aged 18-59.

Treating Premature Ejaculation : Dapoxetine hydrochloride powder

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The problem is thought to be psychological. However, it can also be

biological.

Premature ejaculation has two classifications:

Primary Premature Ejaculation

The man has experienced premature ejaculation throughout his sexually

active life.

Secondary Premature Ejaculation

The condition has developed after the man used to have satisfying sex

without ejaculatory problems.

6. How to use Dapoxetine hydrochloride powder Dapoxet 丨

ine dosage

Dapoxetine hydrochloride powder for saleonline also, the makers buy

dapoxetine hydrochloride powder for sale online, then mix it and make into

dapoxetine tablets or other products. How to use dapoxetine?Dapoxetine

dosage?

Treating Premature Ejaculation : Dapoxetine hydrochloride powder

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-One dapoxetine tablet should be taken one to three hours before sexual

activity.

-The dapoxetine tablet can be taken either with or without food. It should be

swallowed whole to avoid getting a bitter taste from the tablet. The

dapoxetine tablet should be taken with a full glass of water.

-Dapoxetine tablet should not be taken more than once every 24 hours. It

should only be taken when sexual activity is anticipated and is not intended

as a regular treatment that is taken each day.

-The recommendeddapoxetine dosageis 30mg(dapoxetine 30mg). If this is

not effective enough your doctor may increase your dapoxetine dosage to

60mg(dapoxetine 60mg), but this should only be done if you have not

experienced any side effects with the lower dose.

-Your doctor will discuss your treatment with you after four weeks or six

dapoxetine dosage of treatment. If treatment with dapoxetine is continued

your doctor will need to see you every six months.

Dapoxetine dosage: dapoxetine 30mg and dapoxetine 60mg

Treating Premature Ejaculation : Dapoxetine hydrochloride powder

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7. Dapoxetine hydrochloride effects?

How long does dapoxetine last? What are dapoxetine hydrochloride

effects? The following summary data are taken from the article Dapoxetine: a

new option in the medical management of premature ejaculation McMahon,

Chris G, Ther Adv Urol. 2012 October; 4(5): 233-251, where the author

presents information and results of clinical trials of dapoxetine. We

encourage physicians and patients to read the entire document dapoxetine 丨

research.

The most comprehensive results from this work comes from the Phase III

studies that included 6,081 subjects ranging in age from 18-82. In a

double-blind study, each of roughly one-third of patients received one of the

following dapoxetine doage: dapoxetine 30mg, dapoxetine 60 mg, or a

placebo.

Effects of Dapoxetine on IELT

Inter-Vaginal Latency Time

For men with an average baseline IELT of 0.9 minutes, the average IELT

Treating Premature Ejaculation : Dapoxetine hydrochloride powder

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improved to 3.1 minutes for a 30mg dose and 3.6 minutes for a 60 mg dose.

Patients taking the placebo improved to 1.9 minutes.

Ejaculation-Related Sexual Satisfaction

% Good/Very Good Ejaculatory Control

The first of the subjective scores is the subject's feeling of having ejaculatory

control. The per cent of subjects that believed that they had"good" or "very

good" control is shown in this chart.