Association of age at menarche with metabolic syndrome and its components in rural Bangladeshi women

Akter Shamima, Jesmin Subrina, Islam Mazedul, Sultana Sayeeda, Okazaki Osamu, Hiroe Michiaki, Moroi Masao, Mizutani, Mizutani Taro

Description

Early age at menarche is associated with increased risk of metabolic syndrome in both China and the West. However, little is known about the impact of age at menarche and metabolic syndrome in South Asian women, including those from low-income country, where age at menarche is also falling. The aim of the present study was to investigate whether age at menarche is inversely associated with metabolic syndrome in Bangladeshi women, who are mostly poor and have limited access to and or poor health care facilities. Methods This community-based cross-sectional study was performed using 1423 women aged between 15–75 years from rural Bangladesh in 2009 and 2010. Metabolic syndrome was defined according to standard NCEP-ATP III criteria. Logistic regression was used to estimate the association between age at menarche and metabolic syndrome, with adjustment of potential confounding variables, including age, education, marital status, tobacco users, use of contraceptives and number of pregnancies. Results Early onset of menarche (<12 years) as compared to late onset (>13 years) was found to be associated with a higher prevalence of metabolic syndrome (odds ratio=1.55; 95 % confidence interval =1.05-2.30). Age at onset of menarche was also inversely associated with prevalence of high triglycerides ( P for trend <0.01) and low high-density lipoprotein cholesterol ( P for trend = 0.01), but positively associated with prevalence of high fasting blood glucose ( P for trend =0.02). However, no significant association was found between age at menarche, high blood pressure and elevated waist circumference. Conclusion Early onset of menarche might promote or trigger development of metabolic syndrome. Thus, knowledge of the history of age at onset of menarche may be critical in identifying women at risk of developing metabolic syndrome and those likely to benefit the most from early interventions.

Sujets

• Metabolic syndrome
• Women

Informations

• Publié par: biomed
• Publié le: 01 janvier 2012
• Nombre de lectures: 8
• Langue: English

Extrait

Akteret al. Nutrition & Metabolism2012,9:99 http://www.nutritionandmetabolism.com/content/9/1/99

R E S E A R C HOpen Access Association of age at menarche with metabolic syndrome and its components in rural Bangladeshi women 1,3 1,2*1,3 1,33 3 Shamima Akter, Subrina Jesmin, Mazedul Islam, Sayeeda Nusrat Sultana, Osamu Okazaki , Michiaki Hiroe , 3 2 Masao Moroiand Taro Mizutani

Abstract Background:Early age at menarche is associated with increased risk of metabolic syndrome in both China and the West. However, little is known about the impact of age at menarche and metabolic syndrome in South Asian women, including those from lowincome country, where age at menarche is also falling. The aim of the present study was to investigate whether age at menarche is inversely associated with metabolic syndrome in Bangladeshi women, who are mostly poor and have limited access to and or poor health care facilities. Methods:This communitybased crosssectional study was performed using 1423 women aged between 15–75 years from rural Bangladesh in 2009 and 2010. Metabolic syndrome was defined according to standard NCEPATP III criteria. Logistic regression was used to estimate the association between age at menarche and metabolic syndrome, with adjustment of potential confounding variables, including age, education, marital status, tobacco users, use of contraceptives and number of pregnancies. Results:Early onset of menarche (<12 years) as compared to late onset (>13 years) was found to be associated with a higher prevalence of metabolic syndrome (odds ratio=1.55; 95 % confidence interval =1.052.30). Age at onset of menarche was also inversely associated with prevalence of high triglycerides (Pfor trend <0.01) and low highdensity lipoprotein cholesterol (Pfor trend = 0.01), but positively associated with prevalence of high fasting blood glucose (Pfor trend =0.02). However, no significant association was found between age at menarche, high blood pressure and elevated waist circumference. Conclusion:Early onset of menarche might promote or trigger development of metabolic syndrome. Thus, knowledge of the history of age at onset of menarche may be critical in identifying women at risk of developing metabolic syndrome and those likely to benefit the most from early interventions. Keywords:Age at menarche, Metabolic syndrome, Women, Rural Bangladesh

Background Metabolic syndrome is a cluster of risk factors that include obesity, insulin resistance, dyslipidemia, and hypertension. Collectively, these factors increase the risk for cardiovas cular disease and type 2 diabetes [1,2]. Over the past two decades, there has been a noticeable worldwide increase

* Correspondence: [e-mail] 1 Health & Disease Research Center for Rural Peoples (HDRCRP), 14/15, 1st Floor, Probal Housing Ltd., Shekertak (Adjacent to Shekertak Road 1), Mohammadpur, Dhaka 1207, Bangladesh 2 Graduate School of Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki 3058575, Japan Full list of author information is available at the end of the article

in the prevalence of metabolic syndrome, including more recently in developing countries, where the prevalence has been much lower [3,4]. This new development has further compounded the challenges that the weak health system in developing countries is still struggling to cope with, i.e., communicable diseases [5]. The prevalence of metabolic syndrome in women tend to be greater than in men in many developing countries [4]. In view of these gender disparities, it is critical that we identify women at risk of contracting these diseases earlier on in life for effective interventions and outcomes.

© 2012 Akter et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.