Effects of transcranial magnetic stimulation over the dorsolateral prefrontal cortex on cognitive control and on the autonomic nervous system [Elektronische Ressource] / vorgelegt von Mario Städtgen
Effects of Transcranial Magnetic Stimulation over the Dorsolateral Prefrontal Cortex on Cognitive Control and on the Autonomic Nervous System Von der Medizinischen Fakultät der Rheinisch-Westfälischen Technischen Hochschule Aachen zur Erlangung des akademischen Grades eines Doktors der Theoretischen Medizin genehmigte Dissertation vorgelegt von Dipl.-Psych. Mario Städtgen aus Gotha Berichter: Herr Universitätsprofessor Dr.phil. Dipl.-Psych. Siegfried Gauggel Dr.rer.nat. Klaus Willmes - von Hinckeldey Tag der mündlichen Prüfung: 6. Mai 2008 Diese Dissertation ist auf den Internetseiten der Hochschulbibliothek online verfügbar. 2 Table of contents Abreviatons 5 1 General Introduction 7 1.1 Prefrontal cortex and cognitive control - Motivation for the first study 7 1.2 Prefrontal cortex and cortical control of the autonomic nervous system – for the second study 10 2 Study 1: Effects of Transcranial Magnetic Stimulation over the Dorsolateral Prefrontal Cortex on the Inhibition of Initiated Responses 13 2.1 Introduction 13 2.2 Methods 14 2.2.1 Participants 14 2.2.2 Stop-Signal Paradigm 15 2.2.2.1 Apparatus and Stimuli 2.2.2.2 Design procedure 2.2.3 TMS Stimulation 17 2.2.4 Data analysis 18 2.3 Result 19 2.
Effects of Transcranial Magnetic Stimulation over the Dorsolateral Prefrontal Cortex on Cognitive Control and on the Autonomic Nervous System
Von der Medizinischen Fakultät der Rheinisch-Westfälischen Technischen Hochschule Aachen zur Erlangung des akademischen Grades eines Doktors der Theoretischen Medizin genehmigte Dissertation vorgelegt von Dipl.-Psych. Mario Städtgen aus Gotha
Berichter: Herr Universitätsprofessor Dr.phil. Dipl.-Psych. Siegfried Gauggel Herr Universitätsprofessor Dr.rer.nat. Klaus Willmes - von Hinckeldey Tag der mündlichen Prüfung: 6. Mai 2008 Diese Dissertation ist auf den Internetseiten der Hochschulbibliothek online verfügbar.
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Table of contents
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Abbreviations 5 1 General Introduction 7 1.1 Prefrontal cortex and cognitive control -Motivation for the first study 7 1.2 Prefrontal cortex and cortical control of the autonomic nervous system Motivation for the second study 10 2 Study 1: Effects of Transcranial Magnetic Stimulation over the Dorsolateral Prefrontal Cortex on the Inhibition of Initiated Responses 2.1 Introduction 2.2 Methods 2.2.1 Participants 2.2.2 Stop-Signal Paradigm 2.2.2.1 Apparatus and Stimuli 2.2.2.2 Design and procedure 2.2.3 TMS Stimulation 2.2.4 Data analysis 2.3 Results 2.4 Discussion 3 Study 2: Differential Involvement of Left and Right Dorsolateral Prefrontal Cortex in Cortical Control of the Autonomic Nervous System 3.1 Introduction 3.2 Methods 3.2.1 Participants 3.2.2 ECG Recording 3.2.3 TMS Protocol 3.2.4 Control Experiment
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3.4 3.5 4 5 6 7 8
3.2.5 Power spectrum analysis of heart rate variability 3.2.6 Statistical analysis Results 3.4.1 Main Experiment 3.4.2 Control Experiment Discussion
General Conclusion and Future Perspective
Deutschsprachige Zusammenfassung
References
Acknowledgments
Curriculum Vitae
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AbbreviationsACC Ag-AgCl ANS ANOVA CAN CRT DLPFC ECG EEG FFT fMRI HFnu HRV Hz IFG LFnu MFG MRI MRT ms PET PFC rTMS SOA SSRT STN tDCS TMS
Anterior cingulate cortex Silver-silver chloride Autonomic nervous system Analysis of variance Central autonomic network Choice reaction time Dorsolateral prefrontal cortex ElectrocardiogramElectroencephalographyFast-Fourier Transformation Functional magnetic resonance imaging High frequency power, expressed in normalized units Heart rate variability Hertz Inferior frontal gyrus Low frequency power, expressed in normalized units Middle frontal gyrus Magnetic resonance imaging Mean go reaction time Milliseconds Positron emission tomography Prefrontal cortex Repetitive transcranial magnetic stimulation Stimulus onset asynchrony Stop-signal reaction time Subthalamic nucleus Transcranial direct current stimulation Transcranial magnetic stimulation