Molecular evolution of the inflated calyx syndrome(ICS) in Withania (Solanaceae)Inaugural-Dissertation zurErlangung des Doktorgradesder Mathematisch-Naturwissenschaftlichen Fakultätder Universität zu Kölnvorgelegt vonMuhammad Ramzan Khanaus Islamabad/PakistanKöln, 2009Diese Arbeit wurde amMax-Planck-Institut für Züchtungsforschung in Kölnin der Abteilung Molekulare Pflanzengenetik angefertigtBerichterstatter:Prof. Dr. Heinz SaedlerProf. Dr. Wolfgang WerrTag der mündlichen Prüfung: 21-04-2009A necklace made of Withania´s berriesW. somnifera has a long history as a medicinal plant. In the Ayurvedic tradition it is knownas ashwaganda (Horse power) or Ayurvedic ginseng and tonic and is used for a wide varietyof ailments. Its leaves and berries have been found with Egyptian mummies. (Source:Botanical Museum Berlin)TABLE OF CONTENTSTable of contents1 Introduction...................................................................................................... 11.1 The molecular basis of morphological innovations............................................... 11.2 Gene duplication and diversification.................................................................... 11.3 The MADS-box transcription factors ................................................................... 21.4 MADS-box genes and flower development......................................................... 51.5 The ABCDE model .........................................................