Red blood cell distribution width and iron deficiency anemia among pregnant Sudanese women

Abdelrahman, Gasim, Musa, Elbashir, Adam, Adam Ishag

Description

Iron deficiency anemia (IDA) is a major health problem during pregnancy and it has adverse effects on the mother and the newborn. Red cell distribution width (RDW), which is a quantitative measure for red cell size variation (anisocytosis), is a predictor of IDA. Little is known regarding RDW and IDA during pregnancy. Methods A cross sectional study was conducted at the antenatal clinic of Khartoum Hospital, Sudan, to determine the performance of RDW in the diagnosis of IDA using serum ferritin as a gold standard. Results Among 194 pregnant women with a gestational period of 21.4 ± 6.5 weeks, 57 (29.4%) had IDA according to serum ferritin levels (<15 μg/l) and 61 (31.4%) had IDA according to RDW (>14.5). The sensitivity, specificity, positive predictive value, and negative predictive value of RDW where serum ferritin was the gold standard were 43.8% (95% CI: 31.4–57.0%), 73.7% (95% CI: 65.8–80.5%), 41.0% (95% CI: 29.2–53.6%), and 76.0% (95% CI: 68.1–82.6%), respectively. Conclusions In this study, we found that RDW has a poor performance in diagnosing IDA among pregnant women compared with serum ferritin as the gold standard. Virtual slides The virtual slides for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1721072967826303

Sujets

• Anemia
• Pregnancy
• Red blood cell distribution width
• Sudán

Informations

• Publié par: biomed
• Publié le: 01 janvier 2012
• Nombre de lectures: 32
• Langue: English

Extrait

Abdelrahmanet al. Diagnostic Pathology2012,7:168 http://www.diagnosticpathology.org/content/7/1/168

R E S E A R C HOpen Access Red blood cell distribution width and iron deficiency anemia among pregnant Sudanese women 1 1,31,4 2,42,4* Esam G Abdelrahman , Gasim I Gasim, Imad R Musa, Leana M Elbashirand Ishag Adam

Abstract Background:Iron deficiency anemia (IDA) is a major health problem during pregnancy and it has adverse effects on the mother and the newborn. Red cell distribution width (RDW), which is a quantitative measure for red cell size variation (anisocytosis), is a predictor of IDA. Little is known regarding RDW and IDA during pregnancy. Methods:A cross sectional study was conducted at the antenatal clinic of Khartoum Hospital, Sudan, to determine the performance of RDW in the diagnosis of IDA using serum ferritin as a gold standard. Results:Among 194 pregnant women with a gestational period of 21.4weeks, 57 (29.4%) had IDA according± 6.5 to serum ferritin levels (<15μg/l) and 61 (31.4%) had IDA according to RDW (>14.5). The sensitivity, specificity, positive predictive value, and negative predictive value of RDW where serum ferritin was the gold standard were 43.8% (95% CI: 31.4–57.0%), 73.7% (95% CI: 65.8–80.5%), 41.0% (95% CI: 29.2–53.6%), and 76.0% (95% CI: 68.1–82.6%), respectively. Conclusions:In this study, we found that RDW has a poor performance in diagnosing IDA among pregnant women compared with serum ferritin as the gold standard. Virtual slides:The virtual slides for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/ 1721072967826303 Keywords:Anemia, Pregnancy, Red cell distribution width, Sudan

Background It has been estimated that the highest proportions of individuals affected by anemia are in Africa, e.g. in neighboring Ethiopia, anemia is a major problem for both pregnant (62.7%) and nonpregnant (52.3%) women of childbearing age [1]. However, the prevalence of anemia varies significantly both within and between countries, which indicates a need for local data to help improve preventive programs. Anemia during pregnancy is associated with increased maternal morbidity and mortality, and contributes to 20% of the maternal mor tality in Africa [25]. Anemia is one of the most com mon nutritional deficiency disorders in the world [6]. The World Health Organization (WHO) defines iron

* Correspondence: [e-mail] 2 Faculty of Medicine, University of Khartoum, P.O. Box 102, Khartoum, Sudan 4 Buraidah Central Hospital, Buraidah, Kingdom of Saudi Arabia Full list of author information is available at the end of the article

deficiency anemia (IDA) as anemia accompanied by depleted iron stores and signs of a compromised supply of iron to the tissues [7,8]. Anemia during pregnancy is a large health problem in Sudan, where pregnant women in different regions of Sudan are more susceptible to anemia, irrespective of their age or parity [9,10]. Furthermore, anemia is asso ciated with poor maternal and perinatal outcomes, such as maternal and perinatal mortality [1012]. Because of physiological changes that occur during pregnancy, some of the hematological parameters, such as mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), and mean corpuscular hemoglobin concentration (MCHC), are not sensitive indicators for diagnosing anemia/IDA because they are reduced only when anemia is severe or well established [13]. A peripheral blood film examination provides less informa tion but it requires an expert’s opinion [14,15], and

© 2012 Abdelrahman et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.