Barrett's Esophagus, An issue of Gastroenterology Clinics of North America

Prasad G. Iyer

Description

A thorough update is presented by the Guest Editors on the diagnosis, treatment, and management of Barrett’s Esophagus. Not only do they address the most pertinent clinical issues like screening, biomarkers, surveillance, therapeutics, and predictors of disease progression but they present state of the art material on therapeutic/treatment modalities like EMR, ESD, and ablative therapy. Further, articles are presented on epidemiology, molecular pathogensis, and cost-analysis studies so that the reader will come away with a comprehensive update on Barrett’s Esophagus.

Sujets

• Médecine
• Médecine Générale
• Medical
• Gastroenterology

Informations

• Publié par: Elsevier
• Date de parution: 25 juin 2015
• Nombre de lectures: 0
• EAN13: 9780323388894
• Langue: English
• Poids de l'ouvrage: 2 Mo

Extrait

Clinics Review Articles GASTROENTEROLOGY CLINICS OF NORTH AMERICA
Barrett’s Esophagus

Prasad G. Iyer, MD, MSc, FACG, FASGE
Barrett's Esophagus Unit, Division of Gasteroenterology and Hepatology, May Clini, Rochester, MN, USA

Navtej S. Buttar, MD
Division of Gasteroenterology and Hepatology, May Clini, Rochester, MN, USA
ISSN  0889-8553 Volume 44 • Number 2 • June 2015
Elsevier
Table of Contents
Cover image
Title page
Copyright
Contributors
Consulting Editor
Editors
Authors
Forthcoming Issues
Forthcoming Issues
Recent Issues
Foreword: Barrett’s Esophagus
Preface: Barrett’s Esophagus: New Insights and Progress
Epidemiology of Barrett’s Esophagus and Esophageal Adenocarcinoma
Key points
Introduction
Summary
Molecular Pathogenesis of Barrett Esophagus
Key points
Introduction
Molecular pathways involved in the development of columnar and squamous epithelia
Molecular pathways involved in the development of columnar-type of metaplasia
Molecular factors involved in intestinal differentiation
Molecular signals that drive intestinal metaplasia
The Barrett cell of origin
Summary
Role of Obesity in the Pathogenesis and Progression of Barrett’s Esophagus
Key points
Introduction
Obesity and Barrett’s esophagus: evidence for association
Obesity and Barrett’s esophagus: mechanisms of association
The role of obesity in Barrett’s esophagus progression
Therapeutic implications
Summary
Screening for Barrett’s Esophagus
Key points
Introduction
Rationale for screening
Target population
Minimally invasive Barrett’s esophagus screening techniques
Risk stratification of Barrett’s esophagus
Summary
Surveillance in Barrett’s Esophagus
Key points
Introduction
Incidence of cancer in Barrett’s esophagus
Lead-time and length-time biases
Empirical studies of the effectiveness of surveillance endoscopy
What is the true effectiveness of surveillance?
Cost-effectiveness of surveillance
Guideline recommendations
Empirical evidence for the frequency of surveillance
Biopsy protocol in surveillance
Future directions
Summary
Predictors of Progression to High-Grade Dysplasia or Adenocarcinoma in Barrett’s Esophagus
Key points
Introduction
Endoscopic risk factors
Pathologic risk factors
Epidemiologic risk factors
Protective factors
Summary
Endoscopic Mucosal Resection and Endoscopic Submucosal Dissection for Endoscopic Therapy of Barrett’s Esophagus-related Neoplasia
Key points
Introduction
Endoscopic therapy of Barrett’s esophagus: paradigm shift
Endoscopic evaluation and multidisciplinary approach
Initial staging and endoscopic therapy options for dysplastic Barrett’s esophagus and esophageal adenocarcinoma
Endoscopic mucosal resection
Utility of endoscopic ultrasound before endoscopic mucosal resection
Endoscopic mucosal resection
Patient and procedure preparation
Endoscopic mucosal resection techniques
Postprocedure considerations
Endoscopic submucosal dissection
Preparation
Technique
Complications of endoscopic mucosal resection and endoscopic submucosal dissection
Endoscopic resection: efficacy
Summary
Ablative Endoscopic Therapies for Barrett’s-Esophagus-Related Neoplasia
Key points
Introduction
Principles of mucosal ablation in Barrett’s esophagus
Radiofrequency ablation
Technique of radiofrequency ablation
Outcomes
Complications and management
Cryoablation
Photodynamic ablation
Current controversies/future considerations
Summary
Challenges with Endoscopic Therapy for Barrett’s Esophagus
Key points
Introduction
Preprocedural challenges
Procedural challenges
Postprocedural challenges
Future directions
Summary
Biomarkers in Barrett’s Esophagus
Key points
Introduction
Biomarkers for Barrett’s esophagus diagnosis
Biomarkers for risk stratification in Barrett’s esophagus
Miscellaneous markers
Summary
Chemoprevention in Barrett’s Esophagus
Key points
Introduction
Definition and concept of chemoprevention
Risk stratification of cohort
Druggable targets
End point evaluation
Clinical studies and randomized trials
Summary
The Effect of Proton Pump Inhibitors on Barrett’s Esophagus
Key points
Introduction
Cellular effects of acid reflux and proton pump inhibitors in Barrett’s esophagus
Proton pump inhibitors and control of acid reflux in patients with Barrett’s esophagus
Potential carcinogenic effects of proton pump inhibitors in Barrett’s esophagus
Clinical studies on proton pump inhibitors and the risk of cancer in Barrett’s esophagus
The role of proton pump inhibitors during endoscopic eradication therapy for Barrett’s esophagus
Summary
Cost-Analyses Studies in Barrett’s Esophagus
Key points
Introduction
Summary
Advanced Imaging in Barrett's Esophagus
Key points
Introduction
High-definition white light examination
Dye-based chromoendoscopy
Optical chromoendoscopy
Autofluorescence imaging
Confocal laser endomicroscopy
Optical coherence tomography
Emerging technologies
Summary
Surgical Management of Barrett’s Esophagus
Key points
Introduction
Goals of therapy for Barrett’s esophagus
Limitations of medical therapy in patients with Barrett’s esophagus
Benefits of antireflux surgery
Evolution in therapy for Barrett’s esophagus with early neoplasia
Esophagectomy for early esophageal neoplasia
Studies comparing esophagectomy and endoscopic therapies for early esophageal neoplasia
Summary
Genetic and Epigenetic Alterations in Barrett’s Esophagus and Esophageal Adenocarcinoma
Key points
Introduction
Genetic alterations in Barrett’s esophagus, Barrett’s esophagus with dysplasia, and esophageal adenocarcinoma
Epigenetic alterations in Barrett’s esophagus, Barrett’s esophagus with dysplasia, and esophageal adenocarcinoma
Clinical implications
Summary
Index
Copyright
Elsevier
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GASTROENTEROLOGY CLINICS OF NORTH AMERICA Volume 44, Number 2
June 2015 ISSN 0889-8553, ISBN-13: 978-0-323-38888-7
Editor: Kerry Holland
Developmental Editor: Susan Showalter
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