Hepatocellular Carcinoma in Adults and Children, An Issue of Clinics in Liver Disease

Adrian Reuben

Description

Dr. Reuben provides a timely update to the topic of HCC, which was last covered in 2011. The highly respected authors in his issue address advances in imaging for diagnosis, surgical resection and liver transplantation, and local and systemic therapy. The breadth of the topic is covered, with articles devoted to histopathology, classification and staging, and screening and detection.

Sujets

• Medical
• Médecine
• Hepatology

Informations

• Publié par: Elsevier
• Date de parution: 03 juin 2015
• Nombre de lectures: 0
• EAN13: 9780323393416
• Langue: English
• Poids de l'ouvrage: 10 Mo

Extrait

Clinics Review Articles CLINICS IN LIVER DISEASE
Hepatocellular Carcinoma in Adults and Children

Adrian Reuben, BSc, MBBS, FRCP
Division of Gastroenterology and Hepatology, Department of Medicine, Medical University of South Carolina, Charleston, SC, USA
ISSN  1089-3261 Volume 19 • Number 2 • May 2015
Elsevier
Table of Contents
Cover image
Title page
Copyright Page
Contributors
Consulting Editor
Editor
Authors
Forthcoming Issues
Forthcoming Issues
Recent Issues
Preface: Hepatocellular Carcinoma in Adults and Children
Global Epidemiology of Hepatocellular Carcinoma
Key points
Introduction
Incidence and mortality
Hepatocellular carcinoma risk factors and prevention
Chemoprevention
Summary
Anatomic Pathology of Hepatocellular Carcinoma
Key points
Introduction
Clinical data
Hematoxylin-eosin stain evaluation of the directed biopsy for hepatocellular carcinoma
Further work-up of suspected hepatocellular carcinoma
Precursor lesions and early hepatocellular carcinoma in cirrhosis
Summary
Pathogenesis and Prognosis of Hepatocellular Carcinoma at the Cellular and Molecular Levels
Key points
Introduction
Predicting tumor behavior: a high-throughput approach
Cell of origin and the diversity in hepatocellular carcinomas
Plasticity of hepatocellular carcinoma depends on the microenvironment
Stemness, a way to survive in a hostile environment
Summary
Classification and Staging of Hepatocellular Carcinoma
Key points
Introduction
Common classification and staging methods
Selecting treatment modalities based on stage of hepatocellular carcinoma
Discussion
Summary
Screening and Detection of Hepatocellular Carcinoma
Key points
Role of screening for hepatocellular carcinoma
Definition of the at-risk population
Surveillance tests
Screening interval
Role of alpha fetoprotein in screening
Diagnosis of hepatocellular carcinoma
Imaging modalities
Need for needle biopsy/limitations
Safety of biopsy/risk of seeding
Role of currently used tumor markers in hepatocellular carcinoma diagnosis
Summary
Elevated Alpha-Fetoprotein
Key points
Introduction
Surveillance for hepatocellular carcinoma
Serum alpha-fetoprotein
Risk biomarkers for hepatocellular carcinoma
Investigational tumor markers
Summary
Imaging of Hepatocellular Carcinoma
Key points
Introduction
Liver imaging reporting and data system
Liver imaging reporting and data system 1
Liver imaging reporting and data system 2
Liver imaging reporting and data system 3
Liver imaging reporting and data system 4
Liver imaging reporting and data system 5
Liver imaging reporting and data system 5 treated
Liver imaging reporting and data system 5V
Nonhepatocellular carcinoma malignancy
Summary
Oncogenic Viruses and Hepatocellular Carcinoma
Key points
Introduction
Pathogenesis
Risk of hepatocellular carcinoma in a noncirrhotic liver
Prevention of hepatocellular carcinoma in patients with chronic viral hepatitis B and C
Nonalcoholic Fatty Liver Disease, Diabetes, Obesity, and Hepatocellular Carcinoma
Key points
Introduction
Obesity, diabetes, nonalcoholic fatty liver disease, and nonalcoholic steatohepatitis as risk factors for hepatocellular carcinoma
Hepatocellular carcinoma in nonalcoholic fatty liver disease without cirrhosis
Pathogenesis of hepatocellular carcinoma in obesity, diabetes, and nonalcoholic fatty liver disease
Summary
Surgical Resection and Liver Transplantation for Hepatocellular Carcinoma
Key points
Hepatic resection for hepatocellular carcinoma
Liver transplantation for hepatocellular carcinoma
How the authors do it
Locoregional Therapy of Hepatocellular Carcinoma
Key points
Introduction
Diagnostic approach to locoregional therapy
Endovascular embolotherapies
Ablative therapies
Summary
Systemic Therapy of Hepatocellular Carcinoma
Key points
Systemic therapy for hepatocellular carcinoma
Sorafenib
Sunitinib
Brivanib
Summary
Hepatocellular Carcinoma in Children
Key points
Hepatocellular carcinoma in children
Summary
Copyright Page
Elsevier
1600 John F. Kennedy Boulevard • Suite 1800 • Philadelphia, Pennsylvania, 19103-2899
http://www.theclinics.com
CLINICS IN LIVER DISEASE Volume 19, Number 2
May 2015 ISSN 1089-3261, ISBN-13: 978-0-323-39340-9
Editor: Kerry Holland
Developmental Editor: Meredith Clinton
© 2015 Elsevier Inc. All rights reserved.
This periodical and the individual contributions contained in it are protected under copyright by Elsevier, and the following terms and conditions apply to their use:
Photocopying Single photocopies of single articles may be made for personal use as allowed by national copyright laws. Permission of the Publisher and payment of a fee is required for all other photocopying, including multiple or systematic copying, copying for advertising or promotional purposes, resale, and all forms of document delivery. Special rates are available for educational institutions that wish to make photocopies for non-profit educational classroom use. For information on how to seek permission visit www.elsevier.com/permissions or call: ([phone] (UK)/([phone] (USA).
Derivative Works Subscribers may reproduce tables of contents or prepare lists of articles including abstracts for internal circulation within their institutions. Permission of the Publisher is required for resale or distribution outside the institution. Permission of the Publisher is required for all other derivative works, including compilations and translations (please consult www.elsevier.com/permissions ).
Electronic Storage or Usage Permission of the Publisher is required to store or use electronically any material contained in this periodical, including any article or part of an article (please consult www.elsevier.com/permissions ). Except as outlined above, no part of this publication may be reproduced, stored in a retrieval system or transmitted in any form or by any means, electronic, mechanical, photocopying, recording or otherwise, without prior written permission of the Publisher.
Notice No responsibility is assumed by the Publisher for any injury and/or damage to persons or property as a matter of products liability, negligence or otherwise, or from any use or operation of any methods, products, instructions or ideas contained in the material herein. Because of rapid advances in the medical sciences, in particular, independent verification of diagnoses and drug dosages should be made.
Although all advertising material is expected to conform to ethical (medical) standards, inclusion in this publication does not constitute a guarantee or endorsement of the quality or value of such product or of the claims made of it by its manufacturer.
Clinics in Liver Disease (ISSN 1089-3261) is published quarterly by Elsevier Inc., 360 Park Avenue South, New York, NY 10010-1710. Months of issue are February, May, August, and November. Business and Editorial Offices: 1600 John F. Kennedy Blvd., Ste. 1800, Philadelphia, PA 19103-2899. Customer Service Office: 3251 Riverport Lane, Maryland Heights, MO 63043. Periodicals postage paid at New York, NY and additional mailing offices. Subscription prices are $295.00 per year (U.S. individuals), $145.00 per year (U.S. student/resident), $401.00 per year (U.S. institutions), $395.00 per year (international individuals), $200.00 per year (international student/resident), $498.00 per year (international instituitions), $340.00 per year (Canadian individuals), $200.00 per year (Canadian student/resident), and $498.00 per year (Canadian institutions). Foreign air speed delivery is included in all Clinics subscription prices. All prices are subject to change without notice. POSTMASTER: Send address changes to Clinics in Liver Disease , Elsevier Health Sciences Division, Subscription Customer Service, 3251 Riverport Lane, Maryland Heights, MO 63043. Customer Service: Telephone: [phone] (U.S. and Canada); 314-447-8871 (outside U.S. and Canada). Fax: [phone]. E-mail: [e-mail] (for print support); [e-mail] (for online support).
Reprints . For copies of 100 or more of articles in this publication, please contact the Commercial Reprints Department, Elsevier Inc., 360 Park Avenue South, New York, NY 10010-1710. Tel.: [phone]; Fax: [phone]; E-mail: [e-mail] .
Clinics in Liver Disease is covered in MEDLINE/PubMed (Index Medicus) , Science Citation Index Expanded, Journal Citation Reports/Science Edition, and Current Contents/Clinical Medicine.
Printed in the United States of America.
Contributors

Consulting Editor
NORMAN GITLIN, MD, FRCP (LONDON), FRCPE (EDINBURGH), FACG, FACP
Formerly, Professor of Medicine, Chief of Hepatology, Emory University; Currently, Consultant, Atlanta Gastroenterology Associates, Atlanta, Georgia

Editor
ADRIAN REUBEN, BSc, MBBS, FRCP, FACG, FAASLD
Professor Emeritus, Division of Gastroenterology and Hepatology, Department of Medicine, Medical University of South Carolina, Charleston, South Carolin