Medical Microbiology E-Book

Ken Rosenthal, Michael A. Pfaller, Patrick R. Murray

Description

Turn to Medical Microbiology, 8th Edition for a thorough, clinically relevant understanding of microbes and their diseases. This succinct, easy-to-use text presents the fundamentals of microbiology and immunology in a clearly written, engaging manner—effectively preparing you for your courses, exams, and beyond.

• Coverage of basic principles, immunology, laboratory diagnosis, bacteriology, virology, mycology, and parasitology help you master the essentials.

• Review questions at the end of each chapter correlate basic science with clinical practice to help you understand the clinical relevance of the organisms examined.

• Clinical cases illustrate the epidemiology, diagnosis, and treatment of infectious diseases, reinforcing a clinical approach to learning.

• Full-color clinical photographs, images, and illustrations help you visualize the clinical presentations of infections.

• Summary tables and text boxes emphasizing essential concepts and learning issues optimize exam review.

• Additional images, 200 self-assessment questions, NEW animations, and more.

• Student Consult eBook version included with purchase. This enhanced eBook experience includes access -- on a variety of devices -- to the complete text, videos, images, and references from the book.
• Thoroughly updated chapters include the latest information on the human microbiome and probiotics/prebiotics; including a new chapter on Human Microbiome In Health and Disease.
• NEW chapter summaries introduce each microbe chapter, including trigger words and links to the relevant chapter text (on e-book version on Student Consult), providing a concise introduction or convenient review for each topic.
• Online access to the complete text, additional images, 200 self-assessment questions, NEW animations, and more is available through Student Consult.

Sujets

• Médecine
• Médecine de laboratoire
• Medical
• Microbiology

Informations

• Publié par: Elsevier
• Date de parution: 15 septembre 2015
• Nombre de lectures: 9
• EAN13: 9780323359528
• Langue: English
• Poids de l'ouvrage: 13 Mo

Extrait

Medical Microbiology
8TH EDITION
PATRICK R. MURRAY, PhD
Senior Worldwide Director, Scientific Affairs
BD Diagnostics Systems
Sparks, Maryland;
Adjunct Professor, Department of Pathology
University of Maryland School of Medicine
Baltimore, Maryland
KEN S. ROSENTHAL, PhD
Professor of Biomedical Sciences
Director of Microbiology and Immunology
Roseman University of Health Sciences College of Medicine
Las Vegas, Nevada;
Emeritus Professor
Northeastern Ohio Medical University
Rootstown, Ohio
MICHAEL A. PFALLER, MD
Chief Medical Officer
T2 Biosystems
Lexington, Massachusetts;
Professor Emeritus
University of Iowa College of Medicine and College of Public Health
Iowa City, Iowa

NOTE TO INSTRUCTORS:
Contact your Elsevier Sales Representative for teaching resources, including slides and image banks, for Medical Microbiology, 8e, or request these supporting materials at: http://evolve.elsevier.com/Murray/microbiology/
Table of Contents
Cover image
Title page
Copyright
Dedication
Preface
To Our Future Colleagues: The Students
Section 1 Introduction
Chapter 1 Introduction to Medical Microbiology
Viruses
Bacteria
Fungi
Parasites
Immunology
Microbial Disease
Diagnostic Microbiology
Summary
Chapter 2 Human Microbiome in Health and Disease
Human Microbiome Project
Core Microbiome
Evolution of the Microbiome and Normal Flora
Role of the Microbiome in Disease
Diagnostics and Therapeutics
Probiotics
Perspective
Questions
Answers
Bibliography
Chapter 3 Sterilization, Disinfection, and Antisepsis
Sterilization
Disinfection
Antisepsis
Mechanisms of Action
Questions
Answers
Bibliography
Section 2 General Principles of Laboratory Diagnosis
Chapter 4 Microscopy and in Vitro Culture
Microscopy
In Vitro Culture
Questions
Answers
Bibliography
Chapter 5 Molecular Diagnosis
Detection of Microbial Genetic Material
Detection of Proteins
Questions
Answers
Bibliography
Chapter 6 Serologic Diagnosis
Antibodies
Methods of Detection
Immunoassays for Cell-Associated Antigen (Immunohistology)
Immunoassays for Antibody and Soluble Antigen
Serology
Questions
Answers
Bibliography
Section 3 Basic Concepts in the Immune Response
Chapter 7 Elements of Host Protective Responses
Soluble Activators and Stimulators of Innate and Immune Functions
Cells of the Immune Response
Questions
Answers
Bibliography
Chapter 8 Innate Host Responses
Barriers to Infection
Soluble Components of Innate Responses
Cellular Components of Innate Responses
Activation of Innate Cellular Responses
Normal Flora-Associated Responses
Inflammation
Bridge to Antigen-Specific Immune Responses
Questions
Answers
Bibliography
Chapter 9 Antigen-Specific Immune Responses
Immunogens, Antigens, and Epitopes
T Cells
Cell Surface Receptors of T Cells
Development of T Cells
Initiation of T-Cell Responses
Activation of CD4 T Cells and Their Response to Antigen
CD8 T Cells
NKT Cells
B Cells and Humoral Immunity
Immunoglobulin Types and Structures
Immunogenetics
Antibody Response
Questions
Answers
Bibliography
Chapter 10 Immune Responses to Infectious Agents
Antibacterial Responses
Antiviral Responses
Specific Immune Responses to Fungi
Specific Immune Responses to Parasites
Other Immune Responses
Immunopathogenesis
Autoimmune Responses
Immunodeficiency
Questions
Answers
Bibliography
Chapter 11 Antimicrobial Vaccines
Types of Immunizations
Immunization Programs
Questions
Answers
Bibliography
Section 4 Bacteriology
Chapter 12 Bacterial Classification, Structure, and Replication
Differences between Eukaryotes and Prokaryotes
Bacterial Classification
Bacterial Structure
Structure and Biosynthesis of the Major Components of the Bacterial Cell Wall
Cell Division
Spores
Questions
Answers
Bibliography
Chapter 13 Bacterial Metabolism and Genetics
Bacterial Metabolism
Bacterial Genes and Expression
Bacterial Genetics
Questions
Answers
Bibliography
Chapter 14 Mechanisms of Bacterial Pathogenesis
Entry into the Human Body
Colonization, Adhesion, and Invasion
Pathogenic Actions of Bacteria
Immunopathogenesis
Mechanisms for Escaping Host Defenses
Summary
Questions
Answers
Bibliography
Chapter 15 Role of Bacteria in Disease
Bibliography
Chapter 16 Laboratory Diagnosis of Bacterial Diseases
Specimen Collection, Transport, and Processing
Bacterial Detection and Identification
Questions
Answers
Bibliography
Chapter 17 Antibacterial Agents
Inhibition of Cell Wall Synthesis
Inhibition of Protein Synthesis
Inhibition of Nucleic Acid Synthesis
Other Antibiotics
Questions
Answers
Bibliography
Chapter 18 Staphylococcus and Related Gram-Positive Cocci
Answers
Physiology and Structure
Pathogenesis and Immunity
Epidemiology
Clinical Diseases (Box 18-1)
Laboratory Diagnosis
Treatment, Prevention, and Control
Case Study and Questions
Answers
Bibliography
Chapter 19 Streptococcus and Enterococcus
Answers
Streptococcus pyogenes
Streptococcus agalactiae
Other -Hemolytic Streptococci
Viridans Streptococci
Streptococcus pneumoniae
Enterococcus
Case Study and Questions
Answers
Bibliography
Chapter 20 Bacillus
Answers
Bacillus anthracis
Bacillus cereus
Case Study and Questions
Answers
Bibliography
Chapter 21 Listeria and Related Gram-Positive Bacteria
Answers
Listeria monocytogenes
Erysipelothrix rhusiopathiae
Corynebacterium diphtheriae
Case Study and Questions
Answers
Bibliography
Chapter 22 Mycobacterium and Related Acid-Fast Bacteria
Answers
Physiology and Structure of Mycobacteria
Mycobacterium tuberculosis
Other Slow-Growing Mycobacteria
Rapidly Growing Mycobacteria
Nocardia
Other Weakly Acid-Fast Bacteria
Case Study and Questions
Answers
Bibliography
Chapter 23 Neisseria and Related Genera
Answers
Neisseria gonorrhoeae and Neisseria meningitidis
Other Neisseria Species
Case Study and Questions
Answers
Bibliography
Chapter 24 Haemophilus and Related Bacteria
Answers
Haemophilus
Case Study and Questions
Answers
Bibliography
Chapter 25 Enterobacteriaceae
Answers
General Properties
Escherichia coli
Salmonella
Shigella
Yersinia
Other Enterobacteriaceae
Other General Properties
Case Study and Questions
Answers
Bibliography
Chapter 26 Vibrio and Related Bacteria
Answers
Vibrio
Aeromonas
Case Study and Questions
Answers
Bibliography
Chapter 27 Pseudomonas and Related Bacteria
Answers
Pseudomonas
Burkholderia
Stenotrophomonas maltophilia
Acinetobacter
Moraxella
Case Study and Questions
Answers
Bibliography
Chapter 28 Campylobacter and Helicobacter
Answers
Campylobacter
Helicobacter
Case Study and Questions
Answers
Bibliography
Chapter 29 Miscellaneous Gram-Negative Rods
Answers
Bartonella
Bordetella
Other Bordetella Species
Brucella
Cardiobacterium
Francisella
Legionella
Streptobacillus
Case Study 1 and Questions
Case Study 2 and Questions
Case Study 3 and Questions
Case Study 4 and Questions
Answers
Bibliography
Chapter 30 Clostridium
Answers
Clostridium difficile (Clinical Case 30-1)
Clostridium perfringens
Clostridium tetani
Clostridium botulinum
Other Clostridial Species
Case Study and Questions
Answers
Bibliography
Chapter 31 Non-Spore-Forming Anaerobic Bacteria
Answers
Anaerobic Gram-Positive Cocci
Anaerobic Gram-Positive Rods
Anaerobic Gram-Negative Cocci
Anaerobic Gram-Negative Rods
Case Studies and Questions
Answers
Bibliography
Chapter 32 Treponema, Borrelia, and Leptospira
Answers
Treponema
Borrelia
Leptospira
Case Study and Questions
Answers
Bibliography
Chapter 33 Mycoplasma and Ureaplasma
Answers
Physiology and Structure
Pathogenesis and Immunity
Epidemiology
Clinical Diseases (Clinical Case 33-1)
Laboratory Diagnosis (Table 33-2)
Treatment, Prevention, and Control
Case Study and Questions
Answers
Bibliography
Chapter 34 Rickettsia, Ehrlichia, and Related Bacteria
Answers
Rickettsiaceae
Anaplasmataceae
Coxiellaceae
Case Study and Questions
Answers
Bibliography
Chapter 35 Chlamydia and Chlamydophila
Answers
Family Chlamydiaceae
Case Study and Questions
Answers
Bibliography
Section 5 Virology
Chapter 36 Viral Classification, Structure, and Replication
Classification
Virion Structure
Viral Replication
Viral Genetics
Viral Vectors for Therapy
Questions
Answers
Bibliography
Chapter 37 Mechanisms of Viral Pathogenesis
Basic Steps in Viral Disease
Infection of the Target Tissue
Viral Pathogenesis
Viral Disease
Epidemiology
Control of Viral Spread
Questions
Answers
Bibliography
Chapter 38 Role of Viruses in Disease
Viral Diseases
Chronic and Potentially Oncogenic Infections
Infections in Immunocompromised Patients
Congenital, Neonatal, and Perinatal Infections
Bibliography
Websites
Chapter 39 Laboratory Diagnosis of Viral Diseases
Specimen Collection
Cytology
Electron Microscopy
Viral Isolation and Growth
Detection of Viral Proteins
Detection of Viral Genetic Material
Viral Serology
Questions
Answers
Bibliography
Chapter 40 Antiviral Agents and Infection Control
Targets for Antiviral Drugs
Nucleoside Analogs
Nonnucleoside Polymerase Inhibitors
Protease Inhibitors
Antiinfluenza Drugs
Immunomodulators
Infection Control
Questions
Answers
Bibliography
Chapter 41 Papillomaviruses and Polyomaviruses
Answers
Human Papillomaviruses
Polyomaviridae
Case Study and Questions
Answers
Bibliography
Chapter 42 Adenoviruses
Answers
Structure and Replication
Pathogenesis and Immunity
Epidemiology
Clinical Syndromes (Box 42-4)
Laboratory Diagnosis
Treatment, Prevention,