Melanoma, An Issue of Surgical Clinics, E-Book

Kimberly M. Brown

Description

Editors Kimberly Brown and Celia Chao and authors review the latest in Melanoma. Articles will include Epidemiology, Risk Factors, Prevention, and Early Detection; Work-up and Staging of Malignant Melanoma; Principles of Surgical Treatment of Malignant Melanoma; Surviving Cutaneous Melanoma; Locoregional Therapies; Melanoma Vaccines; The Role of Radiation Therapy in Melanoma; Systemic Therapy in Melanoma; Unusual Presentations of Melanoma; Surgical Treatment Options for Stage IV Melanoma; Head and Neck Melanoma; Melanoma in Non-Caucasian Populations and more!

Sujets

• Medical
• Médecine
• Surgery

Informations

• Publié par: Elsevier
• Date de parution: 22 novembre 2014
• Nombre de lectures: 0
• EAN13: 9780323326834
• Langue: English
• Poids de l'ouvrage: 3 Mo

Extrait

Clinics Review Articles SURGICAL CLINICS OF NORTH AMERICA
Melanoma

Dr, Kimberly M. Brown, MD, FACS
Department of Surgery, University of Texas Medical Branch, Galveston, TX, USA

Dr, Celia Chao, MD
Department of Surgery, University of Texas Medical Branch, Galveston, TX, USA
ISSN  0039-6109 Volume 94 • Number 5 • October 2014
Elsevier
Table of Contents
Cover image
Title page
Contributors
Consulting Editor
Editors
Authors
Forthcoming Issues
Forthcoming Issues
Recent Issues
Foreword: Melanoma
Preface: Melanoma
Epidemiology, Risk Factors, Prevention, and Early Detection of Melanoma
Key points
Introduction
Epidemiology and impact
Risk factors
Prevention and early detection
Summary
Workup and Staging of Malignant Melanoma
Key points
Introduction
Principles of biopsy
Pathologic analysis
Role of sentinel lymph node biopsy
Sentinel lymph node procedure
Imaging workup
Laboratory tests
Summary staging
Principles of Surgical Treatment of Malignant Melanoma
Key points
Introduction
Management of primary cutaneous melanoma
Management of the regional lymph nodes
Summary
Surviving Cutaneous Melanoma
Key points
Introduction
Prognostic factors for melanoma survival
Melanoma surveillance
Diagnosis and management of melanoma recurrence
Summary
Locoregional Therapies in Melanoma
Key points
Surgical resection
Intra-arterial regional perfusion therapies
Intralesional and topical therapies
Topical agents
Systemic therapy
Radiation therapy
Summary
Melanoma Vaccines
Key points
Introduction
Immune adjuvants and immunomodulators
Intralesional immunotherapy: tumor (in situ) as vaccine
Future
The Role of Radiation Therapy in Melanoma
Key points
Introduction
Radiation for local control
Radiation for nodal basin control
Summary
Indications and Options for Systemic Therapy in Melanoma
Key points
Introduction
Relevant biology behind current and new melanoma treatments
An algorithm for treating stage IV melanoma
Adjuvant therapy of high-risk melanoma
Summary
Unusual Presentations of Melanoma
Key points
Introduction
Unknown primary melanoma in regional nodes
Unknown primary melanoma in the dermis and subcutaneous tissue
Unknown primary melanoma in visceral organs
Cutaneous melanoma arising in childhood
Melanoma arising on mucosal surfaces
Melanoma arising in the eye
Summary
Surgical Treatment Options for Stage IV Melanoma
Key points
Introduction
Preoperative planning
Surgery as adjuvant therapy
Summary
Head and Neck Melanoma
Key points
Introduction
Clinical presentation
Classification and staging
Investigations
Treatment and pathologic staging
Adjuvant therapy
Reconstruction
Summary
Melanoma in Non-Caucasian Populations
Key points
Introduction
Epidemiology
Etiology
Outcomes
Interventions
Summary
Index
Contributors

Consulting Editor
RONALD F. MARTIN, MD, FACS
Staff Surgeon, Department of Surgery, Marshfield Clinic, Marshfield, Wisconsin; Clinical Associate Professor, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin; Colonel, Medical Corps, United States Army Reserve

Editors
KIMBERLY M. BROWN, MD
Assistant Professor, Department of Surgery, University of Texas Medical Branch, Galveston, Texas
CELIA CHAO, MD, FACS
Associate Professor, Department of Surgery, University of Texas Medical Branch, Galveston, Texas

Authors
ANDREA M. ABBOTT, MD, MS
Department of Cutaneous Oncology, Moffitt Cancer Center, Tampa, Florida
SAÏD C. AZOURY, MD
Halsted Surgery Resident, Department of Surgery, The Johns Hopkins Hospital, Johns Hopkins Medicine, Baltimore, Maryland
CELIA CHAO, MD, FACS
Associate Professor, Department of Surgery, University of Texas Medical Branch, Galveston, Texas
STEVEN L. CHEN, MD, MBA
Associate Professor, Department of General Oncologic Surgery, City of Hope National Medical Center, Duarte, California
JERRY CHERIYAN, MD, MRCS
Department of General Surgery, Marshfield Clinic, Marshfield, Wisconsin
ERIC G. DAVIS, MD
Assistant Professor, The Hiram C. Polk Jr, Department of Surgery, University of Louisville School of Medicine, Louisville, Kentucky
MARK B. FARIES, MD
Director, Donald L. Morton Melanoma Research Program, John Wayne Cancer Institute, Santa Monica, California
GEOFFREY T. GIBNEY, MD
Assistant Member, Department of Cutaneous Oncology, Moffitt Cancer Center; Assistant Professor, Department of Oncologic Sciences, USF Morsani College of Medicine, Tampa, Florida
MARK A. HEALY, MD
Resident, Department of Surgery, University of Michigan, Ann Arbor, Michigan
JOHN M. KANE III, MD
Chief, Melanoma-Sarcoma Service, Department of Surgical Oncology, Roswell Park Cancer Institute, Buffalo, New York
RONDI M. KAUFFMANN, MD, MPH
Department of General Oncologic Surgery, City of Hope National Medical Center, Duarte, California
BRENT KELLY, MD
Associate Professor, Department of Dermatology, University of Texas Medical Branch, Galveston, Texas
CHARLES W. KIMBROUGH, MD
The Hiram C. Polk, Jr, Department of Surgery, University of Louisville School of Medicine, Louisville, Kentucky
JULIE R. LANGE, MD, ScM
Associate Professor, Department of Surgery, The Johns Hopkins Hospital, Johns Hopkins Medicine, Baltimore, Maryland
DELPHINE J. LEE, MD, PhD
Director of Carolyn Dirks and Brett Dougherty Laboratory for Cancer Research; Director of Department of Translational Immunology, John Wayne Cancer Institute, Santa Monica, California
KELLY M. M c MASTERS, MD, PhD
Ben A. Reid Sr, MD, Professor and Chairman, The Hiram C. Polk Jr, Department of Surgery, University of Louisville School of Medicine, Louisville, Kentucky
JANE L. MESSINA, MD
Dermatopathologist, Departments of Anatomic Pathology and Cutaneous Oncology, Moffitt Cancer Center; Professor, Departments of Pathology & Cell Biology and Dermatology, USF Morsani College of Medicine, Tampa, Florida
AMY A. MRAZEK, MD
General Surgery Resident, Department of Surgery, University of Texas Medical Branch, Galveston, Texas
JACQUELINE OXENBERG, DO
Department of Surgical Oncology, Roswell Park Cancer Institute, Buffalo, New York
JUNKO OZAO-CHOY, MD
Department of Surgery, Harbor-UCLA Medical Center, Torrance, California
VERNON K. SONDAK, MD
Chair, Department of Cutaneous Oncology, Moffitt Cancer Center; Professor of Surgery, Departments of Oncologic Sciences and Surgery, USF Morsani College of Medicine, Tampa, Florida
JONATHAN STUBBLEFIELD, BS
School of Medicine, University of Texas Medical Branch, Galveston, Texas
ANDREW URQUHART, MD, FACS
Department of Otolaryngology/Head and Neck Surgery, Marshfield Clinic, Marshfield, Wisconsin
IRIS H. WEI, MD
Resident, Department of Surgery, University of Michigan, Ann Arbor, Michigan
JESSICA WERNBERG, MD, FACS
Adjunct Clinical Assistant Professor, Department of General Surgery/Surgical Oncology, Marshfield Clinic, Marshfield, Wisconsin
SANDRA L. WONG, MD, MS
Associate Professor, Department of Surgery, University of Michigan, Ann Arbor, Michigan
JONATHAN S. ZAGER, MD, FACS
Director of Regional Therapies; Associate Member; Department of Cutaneous Oncology, Moffitt Cancer Center, Tampa, Florida
Contents

Foreword: Melanoma   xi
Ronald F. Martin

Preface: Melanoma   xv
Kimberly M. Brown and Celia Chao

Epidemiology, Risk Factors, Prevention, and Early Detection of Melanoma   945
Saïd C. Azoury and Julie R. Lange
The incidence of melanoma has increased over the past several decades. Despite improved case mortality, overall deaths from melanoma have increased because of the large increase in incidence. Although we have a better understanding of the pathogenesis of melanoma and improved early diagnostic capabilities, the burden of disease and societal costs remain high. This article provides an update on the epidemiology of cutaneous melanoma worldwide and the common risk factors including heritable and modifiable risks, emphasizing the importance of education, early detection, and prevention in reducing the disease burden.

Workup and Staging of Malignant Melanoma   963
Rondi M. Kauffmann and Steven L. Chen
Melanoma continues to be one of the fastest growing cancers in terms of incidence. The workup of melanoma focuses on risk factors based on the visual aspects of a skin lesion. Risk factors including sun exposure increase the risk of melanoma. Staging is based on depth of invasion, mitotic rate, and spread into lymph nodes and other sites. Once diagnosed, wide excision is indicated for the primary lesion, and sentinel node biopsy for all but the thinnest of melanomas. Routine imaging workup for most thinner melanomas should be minimized, and is questionable in the asymptomatic patients even with thicker melanomas.

Principles of