Curriculum Vitae - Go to personal.ph.surrey.ac.uk - University of Surrey

Dr. Mike Harrington

Description

• cours magistral - matière potentielle : hispalensis
• expression écrite

Arnau Rios Huguet 30 January 2012 Address Faculty of Engineering and Physical Sciences Department of Physics The University of Surrey Guildford, Surrey GU2 7XH, United Kingdom. Phone: [phone] E-mail: m01088/ Born: Barcelona (Spain), 15 October, 1980. education Jun 2002 Bachelor degree (licenciado) in Physics, University of Barcelona. Sep 2004 Master degree (DEA, Diploma on Advanced Studies) in Theoretical Physics, University of Barcelona.

• postdoctoral research associate
• approach to nuclear matter at finite temperature
• sep 2004 jan
• research experience sep 2002 feb 2007 phd
• nuclear matter
• effective interaction dependence
• entropy of a correlated system of nucleons
• aug 2009 aug
• physics

Sujets

• Laboratory
• Margueron
• Outline of physics

Informations

• Publié par: rehoh
• Nombre de lectures: 18
• Langue: English

Extrait

Genetics 418 Lecture 1
1/8/12
1) Chromosomes

a) Nuclear

2n = 46
Genetics 418
Lecture 1 46,XX
Human genome organization
46,XY
Wikipedia:Chromosome
2 1
c) Summary
b) Mitochondrial
Feature Nuclear Mit.

genome genome
Size 3100 Mb 16.6 kb
Different DNAs 24 1
Protein encoding genes ~21 000 13
RNA encoding genes > 6000 24
Introns yes no
Repetitive DNA yes no
3 4
3) Transposable elements
2) High-copy number tandemly repeated DNA

a) Types
Class Array size Location



Satellite DNA > 100 kb centromeres

Minisatellite DNA 0.1 - 20 kb telomeres
Microsatellites < 100 bp dispersed
5 6
1Genetics 418 Lecture 1
1/8/12
b) Consume resources
LINEs
Long Interspersed Nuclear Elements Mobilization requires new RNAs and new Proteins
6 - 8 kb
e.g. L1 Continued existence requires DNA replication

SINEs
Short Interspersed Nuclear Elements
100 - 300 bp
e.g. Alu
7 8
c) Cause mutations Providing sites for
inappropriate meiotic cross overs
New insertions can disrupt genes
9 10
d) Facilitate evolution by changing gene expression Alter transcription termination

Alter pre-mRNA splicing
Cordaux and Batzer (2009) The impact of retrotransposons on human
genome evolution. Nature Reviews Genetics 10:691
11 12
2Genetics 418 Lecture 1
1/8/12
Alter the local epigenetic environment Alter transcription factor recruitment to
regulatory regions
13 14
3