M1 Cell Signaling2007 2008partII

Borg

Description

Niveau: Supérieur, Master, Bac+4
PH Domains

• aa - ligands


• ptb domain


• binding specificities


• terminal specificity - irs

Informations

• Publié par: larec
• Nombre de lectures: 7
• Langue: English
• Poids de l'ouvrage: 1 Mo

Extrait

PH Domains

Activation of

Akt

- - - -

PTB

~ 100 AA ligands: pY or not pY N-terminal specificity IRS-1, Shc

PTB

domain

SH2

PDZ domains

are widely

distributed

in genomes

Nourry

et al., 2003

Binding

specificities

SH3

PDZ PTB

WW

PxxP

(p)YxxM

NPxY(p)

PPxY

of

protein

interaction domains

S/TxV orΨxΨ

Some important signaling pathways

Receptors coupled to heterotrimeric G proteins (GPCR)

Constitutive association

GTP dependant-dissociation

GTP dependante association

GTP dependante activation

Dissociation after hydrolysis of GTP