Nano molecular motors
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Nano molecular motors

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Niveau: Supérieur, Master, Bac+4
Nano-6 molecular motors 1 Molecular motors I. Orders of magnitudes (mass, forces,etc..) II. Cytoskeleton (Actin, tubulin, keratin…) III. Energy sources (thermal, chemical); ATP hydrolysis IV. Myosin and deyein based motors (muscles, sperm) V. Mechanisms for molecukar motors

  • examples amino-acid

  • atp

  • kt thermal

  • conformal change

  • chemical atp

  • molecular motors


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Nombre de lectures 30
Poids de l'ouvrage 1 Mo
oMelucalromotsrI.Ordersofmagnitudes (mass, forces,etc..)II.Cytoskeleton(Actin, tubulin, keratin)III.Energysources (thermal, chemical); ATP hydrolysisIV.Myosinanddeyeinbasedmotors(muscles, sperm)V.Mechanismsfor molecukarmotorsNano-6 molecular motors1
D 074ATP=AdenosinetriphosphateExamplesamino-acid~ 300-600 DExamplesaromaticring C6H126*12+12=84 DMass: Dalton 1 H atom1.673 10-27kgOrdersofmagnitudesATP=ADP+Pphosphatetinua2r 5m oktoTrsProtein100 kDSize6-10 nmVolume 120 nm3snietorp 0001-0001nitca(erutcurtsxelpmoc eroMsdica-onima 0005-0052lucelom 6-onaN
evo)noitarelecca(ecroflaitrenielttil59-ytivarg oNsecrofWdV ybg10-6pNn01iNpdmagneticnelasticiViscousbthermalVan der slaaWgravitynkT=4.1410-21J4pN.1nmo1-50 pNi1-1000pNt10-100pN1-1000pNoC-OH10pNNano-6 molecular motorsmcovalentd3eForces in biologypmadr
!A50.0 ni spotss/mμ52=vsn 51=τmn/Np4=κD501=gk22-01 7.1=mm/s.Np06=γD501=gk22-01 7.1=msn 002=τm/s.Nn02=γD2101 2=gk51-01 4=mmuiretcabselacsemit4elastic/viscousFvConformalchangeγ=τκvproteinFNano-6 molecular motorsproteinm=τγInertial/viscousτ=3 ps
0151τμLDs ni mn 01srevoCs/2mμ76=Dnietorp=DTkγTk 21=J02-01 5=mn.Np05MyosinnumbersElastic: conformalchange 5nmstiffness4pN/nmEel=1κδ2=2chemicalk4 T1 t0h-2e1rJmalNano-6 molecular motors5Energies52Tk ATP hydrolysis===282210176
slairetamlacigoloibfossenffitsdnaseitisneD)apG( Esuludom gnuoYCarbonnanotubeleetsplastickeratinnitcatubulin00310224.24.23.2.19vdWforces6cytoskeletonNano-6 molecular motorshemoglobin1.38Chromosome1.36Virus1.15Synapticvesicle1.05densitiestubulin: axons (neurons), spermflagellaactin: muscles,..Keratin: hairs, wool, nails, hoofs, horns,..
yCotksleteno-AActinfilaments (Φ=6nm)tcniUnit ellement(monomer)Two-strandtwistedfibersNano-6 molecular motorspolymer7
ntntnnAAAK][][][egral ndnartsitlumniworgylnonacsremylop gnoLtnemalifdednartsowtdnaenofonoitaziremyloP8typically1000twostrandnavK1[At]KKMultistrandgrowor shrinkattheendsNano-6 molecular motorsFor a single strandn[An]=Kexpn0[At]=[An]=1n01yllacipyt1==va
mm 6elubut-orciMmμ 51nitcAmn 05ANDhtgnelecnetsisreP=pLIETksremyloplacigoloibfognidneB9srotom ralucelom 6-onaNLπ4=Ir4κ=3E3ILy(L)FyIE3microtubule3EI=30 10-24Nm2L=10μmκ=107Nm0.1pN bendthetubule by y=1μmEffectofthermal fluctuation: persistencelengthLpcosθ(s)=expLsppolymer
yCotksleteno-utMicro-tubules(Φ=25nm)13 strandedfilament woundin a cylindricalstructureubilnNano-6 molecular motors01
ATP hydrolysisATPADP+PiTk52PDAThis reactionisusedfor•transition betweentwostate (motion)•Conformation change (springforce)Nano-6 molecular motors11