Weight loss drug lorcaserin HCL side effect_ dosage_ cost _ results CAS 846589-98-8

Weight loss drug lorcaserin HCL side effect_ dosage_ cost _ results CAS 846589-98-8

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Weight loss drug lorcaserin HCL side effect_ dosage_ cost _ results CAS 846589-98-8

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Publié le 29 novembre 2018
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Phcokerwww.phcoker.com Weight loss drug lorcaserin HCL side effect, dosage, cost & results CAS 846589-98-8
Reproduce from
https://www.phcoker.com/lorcaserin-hcl-for-the-treatment-of-obesity/
.............................................................................. FDA Approved weight loss drug: Lorcaserin HCL 3 ........................................................................................................................ Meta description 3 ................................................................................................................................ Introduction 3 ............................................................................................................... Obesity vs Overweight 4 ........................................................ US Study Unveils The Cardiovascular Safety of Lorcaserin 4 ........................................................................................... Lorcaserin and Heart Valve Disease 5 .............................................................................................................................. FDA Approval 6 ................................................................................... Quick Overview of Lorcaserin (846589-98-8) 7 ..................................................................................................... Lorcaserin HCL(846589-98-8) 7 ...................................................................................................................... Structural formula 7 .............................................................................................. Lorcaserin HCL Safety Data Sheet 9 .............................................................................................................. Hazard Description 9 ............................................................................................................... First Aid Measures 9 ........................................................................................................... Personal Protection 10 ........................................................................................................ Handling and storage 10 .............................................................................................................................. Stability 10 .................................................................................................... Lorcaserin Mechanism of Action 11 ................................................................................................................... How to Take Lorcaserin 13 ........................................................................................ Belviq Prescription Information 13 ...................................................................................................................... Missed Dose 14 ........................................................................................................................... Overdose 14 ........................................................... Special Precautions When on Lorcaserin Weight-loss Drug 15 ............................................................................................. Before Taking Lorcaserin (Belviq) 15 ............................................................................................................... Possible Allergies 15 .................................................................................................. Prescription Medications 15 ........................................................................................ Other weight-loss supplements 17 ...................................................................................................... Pregnancy and nursing 17 ......................................................................... Cardiovascular and blood cell conditions 18 ........................................................................................................... When Taking Lorcaserin 18 ............................................................................................................... Diet and exercise 18 ........................................................................................ Additional Tip-Offs When on Lorcaserin 19 ................................................................. Clinical Cautions and Lorcaserin Contraindications 20
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Phcokerwww.phcoker.com ............................................................................................... When to stop taking lorcaserin; 21 ................................................................................................................ Side Effects of Lorcaserin 22 ............................................................................................... Common but Minor Symptoms 22 ....................................................................................................................... Acute symptoms 23 ...................................................................................................................... Storage of Lorcaserin 24 ......................................................................................................... Proper Disposal of Lorcaserin 25 ................................................................................................... Lorcaserin Reviews From Obeses 26 ............................................................................................................................. Effectiveness 26 ....................................................................................................... Side effects are a Turn off! 26 ............................................................................................................... Appetite Suppression 27 ........................................................................................................................................ Costly 27 ............................................................................................................. Withdrawal Symptoms 27 ................................................................................................................... Lorcaserin supplement 28 ............................................................................................................................. 1. Lorcaserin 28 ...................................................................................................................... 2. Lorcaserin Pills 28 ............................................................................................................................... Belviq® 28 ............................................................................................................... Active Ingredient 29 ........................................................................................................... Inactive Ingredients 29 .......................................................................................................................... Belviq XR® 30 ..................................................................................................... Purchase Lorcaserin HCL Online 31 ..................................................................................................................... 1. Lorcaserin Cost 31 ......................................................................................................... Lorcaserin HCL Costs 31 .................................................................................................. 2. How To Buy Lorcaserin HCL 32 .................................................................................................................................................. FAQ 33 .................................................................................................... Is the lorcaserin controlled? 33 .............................................................................. Can you work out while taking lorcaserin? 33 ............................................................................... Does lorcaserin have risks on your body? 34 ............................................................................ How much weight will I lose on lorcaserin? 35 ......................... Have you tried Belviq or a similar appetite suppressant and has it worked? 35 ............................................................................................. Summary On Lorcaserin HCL (Belviq) 36 ....................................................................................................................................... References 36
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Phcokerwww.phcoker.com FDA Approved weight loss drug: Lorcaserin HCL
Meta description
Are you looking for a safer way of losing body weight without kicking up a fuss about
tedious and unproductive workouts? Tryweight loss drug lorcaserin. Find out how
effective the supplement is, lorcaserin mechanism of action, and why it won the
approval of FDA.
Introduction
As at now, about 31% of the US population is either overweight or obese. Further
statistics confirm that 69% of adults who are over 20 years are obese or overweight.
Literally, this means that in every 10 adults within this age bracket, you can sample
up to 6 victims. About 30% of high schoolers are either obese or overweight.
The only sure way to address obesity is through regular workouts, dietary plan,
gastric band surgery, or use of weight-loss drugs. Although slimming pills are quite
effective in shedding a few body pounds, they have been associated with heart valve
damage. Besides, there have been several concerns about the possibilities of mental
health issues.
Until 2012, lorcaserin supplement, also known as Belviq, was never a weight-loss
prescription pill because of the unconfirmed health reasons. But then, a US research
made on several people proved this pill to be safe and effective with no serious
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Phcokerwww.phcoker.com health implications on the human heart. Those using it can lose an average of 5 -10%
of their body weight, on condition that they engage in physical activities and a
low-calorie diet.
Lorcaserin HCL video
https://youtu.be/8bw5ml3MHu8
Obesity vs Overweight
So, what’s the difference between obesity and overweight? If your body mass index
2 (BMI) is over 30kg/m , then you’re obese. If the value ticks between 25 and
2 29.9kg/m , that’s being over-weight.
The root cause of obesity is not quite clear but reasons revolve around genetic,
metabolic, physiological, and behavioral factors. The complexity of this condition
leads to diabetes mellitus, heart disease, hyperlipidemia, apnea, fatty liver disease,
hypertension, and certain cancers.
US Study Unveils The Cardiovascular Safety of Lorcaserin
FDA did not just approve the use of lorcaserin supplement due to the public demand
or its effectiveness in curbing obesity. The key factor that led to its endorsement is
the major US study that was carried out in 3.3 years.
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Phcokerwww.phcoker.com In reference to a study posted onThe New England Journal of Medicine,lorcaserin
proves to be a reliable drug for weight management for both obese and overweight
patients.
The researchers randomly selected 12000 patients who were not only overweight
but also victims of various cardiovascular conditions. From this group, some of the
people were assigned to receive a daily lorcaserin dosage while the rest took a
placebo.
After a year, 39% of the patients given lorcaserin and 17% of those in the placebo
group recorded at least 5% of weight loss. As though that’s not enough, the
lorcaserin group was at a lower risk of developing diabetes although some patents
would end up with serious hypoglycemia.
When a comparison was made between the participants taking lorcaserin and those
on a placebo, there were no records of increased cardiovascular issues on either
group. Only that lorcaserin accelerates weight loss compared to other methods.
Lorcaserin and Heart Valve Disease
So, why did people buy the idea that lorcaserin is tied with heart valve damage? Let
me explain…
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Phcokerwww.phcoker.com There are 14 different types of 5-HT receptors in the human system. Being a
serotonin 2C agonist, lorcaserin targets the 5-HT2Creceptors of the central nervous
system. But then, this receptor is correlated with 5-HT2Band 5-HT2Areceptors.
This is to say that, if 5-HT2Cis stimulated, the other receptors have an equal chance of
being activated. This is quite common in serotonin weight-loss medications, hence,
the prevalence of heart valve problems and pulmonary hypertension among the
users.
In this case, the affinity of lorcaserin on 5-HT2Cis 100x greater than on
5-HT2Breceptors. The daily dose is responsible for the binding affinities. If you
overdose, you’ll exceed the limit and the extra amount will have to bind to the rest of
the receptors. Whereas the activation of 5-HT2Bcauses valvular heart disease, the
stimulation of 5-HT2Aleads to mood changes, feeling ‘high’, euphoria, and
hallucinations.
Currently,weight loss drug lorcaserinis the only treatment that stimulates
5-HT2Bwithout risking cardiovascular damages or pulmonary hypertension.
FDA Approval
The Food and Drug Administration (FDA) first approved the prescription of Belviq to
US adult patients in 2012. This authorization occurred three years after Arena
Pharmaceuticals and Eisai Inc. filed an NDA (New Drug Application) for Lorcaserin. It
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Phcokerwww.phcoker.com took FDA two years to vet the data, including the clinical case studies associated with
lorcaserin, before giving the final judgement.
For almost two decades now, Belviq stands to be the first slimming pill to win the
approval of FDA. Although it is a licensed prescription drug in the US, it has not yet
been approved in Europe.
Quick Overview of Lorcaserin (846589-98-8)
Lorcaserin HCL(846589-98-8)
Lorcaserin hydrochloride is a raw material belonging to the class of serotonin
receptor agonists. It is a chemical compound with CAS no.846589-98-8
Let’s dive into a detailed description of this chemical…
Structural formula
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Phcoker Product Name
Chemical name
CAS no.
Melting point (°C)
pH
Purity
Appearance
Molecular weight
Molecular formula
Solubility (25°C)
Storage temperature
Action
Usage
Synonyms
Lorcaserin hydrochloride
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(R)-8-Chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine
hydrochloride
846589-98-8
193 – 200
4 – 6
99%
White powder
232.15
C11H15Cl2N
· Water
· DMSO (dimethyl sulfoxide)
· Ethanol
-20(°C)
Serotonin 2C Receptor agonist
Adult weight management
· APD-356
· APD 356
· APD356
· Lorqess
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Phcoker
· Belviq
· Belviq Xr
· Lorcaserin HCL
· UNII-0QJF08GDPE
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· (R)-8-Chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine
hydrochloride
· (R)-1H-3-benzazepine,
8-chloro-2,3,4,5-tetrahydro-1-methyl-, hydrochloride
Note that lorcaserin hydrochloride is a pharma-grade compound. Though readily
available in most chemical stores, it should be used strictly for laboratory research,
development, and drug discovery purposes. It is not for human use, and therefore,
not eligible for selling to patients.
Lorcaserin HCL Safety Data Sheet
Hazard Description
First Aid Measures
In line with the GHS system of classification, lorcaserin
hydrochloride is a category IV irritant. It bears the codes;
H302, P264, P301, P312, and P330. It may be toxic through
swallowing, inhalation, ingestion, or upon direct contact
with the skin.
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Phcokerwww.phcoker.com In case of lorcaserin ingestion, wash out the victim’s mouth with plenty of clean
water. Continue with the rinsing for the next 15 minutes, on condition that the
person is conscious. Don’t attempt to give any oral administration if someone is
unconscious.
If the falls on the skin, flush with copious amounts of clean water and mild soap. If on
the eye, use some running water to rinse them for about 15 minutes. Most
well-equipped laboratories have installed safety showers and an eyewash for
convenience when carrying out emergency response.
In case a victim inhales lorcaserin HCL, transfer them to a room with fresh air. If
breathing becomes difficult, use artificial respiration and seek medical assistance.
Personal Protection
Wear a lab coat, safety glasses, and chemical-resistant gloves. Also, use a respirator,
which has been certified by NIOSH.
Handling and storage
Do not inhale the, fumes, dust, spray, or any airborne substances in the laboratory.
Limit the time of exposure as much as possible. During storage, ensure to store
lorcaserin in a sealed container and lock it up securely away from other laboratory
users.
Stability
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Phcokerwww.phcoker.com Lorcaserin is stable under standard and controlled conditions. However, you should
keep it away from strong oxidants as it may trigger product decomposition. The
byproducts are oxides of nitrogen, carbon monoxide, carbon dioxide, and hydrogen
chloride.
Lorcaserin Mechanism of Action
Lorcaserin is a serotonin 2C receptor agonist. The drug has a high affinity for the
human 5-HT2C. It targets specific chemicals in the hypothalamus, which are
responsible for appetite.
Allow me to explain it scientifically… Belviq interacts with the Central Nervous System
(CNS), specifically in the hypothalamus. The drug targets the 5-HT2Creceptors, which
are found on the pro-opiomelanocortin neurons within the arcuate nucleus. This
action prompts the release of alpha-MSH, which is the hormone acting on
melanocortin-4-receptors to suppress one’s appetite. This part of the brain regulates
hunger such that when activated, it will signal the body that you’re full most of the
time.
When taken, the drug decreases the consumption of food and brings about the
feeling of satiation. Although you’ll still feed on a healthy low-calorie diet, Belviq will
control your cravings. You will already be full upon eating so little.
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