Avanafil Compared to Viagra and Cialis for ED Treatment
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Avanafil Compared to Viagra and Cialis for ED Treatment

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13 pages
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http://www.aasraw.com/products/avanafil/ - Avanafil is used to treat men who have erectile dysfunction (also called sexual impotence). Avanafil belongs to a group of medicines called phosphodiesterase 5 (PDE5) inhibitors. These medicines prevent an enzyme called phosphodiesterase type-5 from working too quickly. The penis is one of the areas where this enzyme works.

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Publié le 19 avril 2018
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Avanafil Compared to Viagra and Cialis for ED Treatment
1.What is Avanafil?
Avanafilis used to treat men who have erectile dysfunction (also called s exual impotence). Avanafil belongs to a group of medicines called ph osphodiesterase 5 (PDE5) inhibitors. These medicines prevent an enzyme called phospho diesterase type-5 from working too quickly. The penis is one of the areas where this enzy me works.
Erectile dysfunction is a condition where the penis does not ha rden and expand when a man is sexually excited, or when he cannot keep an erection. Wh en a man is sexually stimulated, his body's normal response is to increase blood flo w to his penis to produce an erection. By controlling the enzyme, avanafil helps to mainta in an erection after the penis is stroked by increasing blood flow to the penis. Without physi cal action to the penis, such as that occurring during sexual intercourse, avanafil will not w ork to cause an erection.
2.What isAvanafil powder?
Avanafil raw powder,the material of Avanafil, a kind of White powder, many steroids products supplier usuallybuy high purity Avanafil powderonline, make it into all kinds of brand finished Avanafil, the detail of theAvanafil rawin AAS as below:
Name: Avanafil
CAS: 330784-47-9
Molecular Formula: C23H26ClN7O3
Molecular Weight: 483.95
Melt Point: 150-152°C
Storage Temp.: RT
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3.How DoesAvanafil Works?
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Avanafil is in a class of medications called phosphodiestera se (PDE) inhibitors.It is used to treat erectile dysfunction (ED: impotence; inability to get or keep an erection in men). This male enhancement product got its name from its main active ingredient which helps the circulation of blood in the body in a normal way. There are othe r ingredients that makes Avanafil effective but don’t have that much impact and effects that its main ingredient has to offer.
It works by increasing blood flow to the penis during sexual stim ulation. This increased blood flow can cause an erection. Avanafil does not cure erectil e dysfunction or increase sexual desire. Avanafil does not prevent pregnancy or the spread of sexually transmitted diseases such as human immunodeficiency virus (HIV).
Avanafil is an oral drug that is used for treating impotence (the i nability to attain or maintain a penile erection), also known as erectile dysfunctio n (ED). It is in a class of drugs called phosphodiesterase inhibitors that also include s tadalafil (Cialis), sildenafil (Viagra) and vardenafil (Levitra). Erection of the penis is caused by the filling of the penis with blood. Filling occurs because the blood vessels that brin g blood to the penis increase in size and deliver more blood to the penis, and, at the same tim e, the blood vessels that take blood away from the penis decrease in size and remove less bl ood from the penis. Sexual stimulation that leads to an erection causes the produc tion and release of nitric oxide in the penis. The nitric oxide causes an enzyme, guanyl ate cyclase, to produce cyclic guanosine monophosphate (cGMP). It is cGMP that is prima rily responsible for increasing and decreasing the size of blood vessels carrying blo od to and from the penis, respectively, and causing an erection. When the cGMP is destroy ed by another enzyme, phosphodiesterase-5, the blood vessels return to their norma l size, blood leaves the penis, and the erection ends. Avanafil prevents phosphodiesterase-5 f rom destroying cGMP so that cGMP stays around longer. The persistence of cGMP leads to a more prolonged engorgement of the penis with blood. Avanafil was approved by t he FDA in April 2012.
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4.How toUse Avanafil?
Before taking avanafil
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tell your doctor and pharmacist if you are allergic to avanafil, any other medications, or any of the ingredients in avanafil tablets. A sk your pharmacist or check the patient information for a list of the ingredients. Do not take avanafil if you are taking or have recently taken rioc iguat (Adempas) or nitrates such as isosorbide dinitrate (Dilatrate-SR, Isordil, i n BiDil), isosorbide mononitrate (Monoket), and nitroglycerin (Minitran, Nitro-Dur, Ni tromist, Nitrostat, others). Nitrates come as tablets, sublingual (under the tongue ) tablets, sprays, patches, pastes, and ointments. Ask your doctor if you are not sure if any of your medications contain nitrates. do not take street drugs containing nitrates such as amyl nitrate and butyl nitrate ('poppers') while taking avanafil. Tell your doctor and pharmacist what other prescription and no nprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: alpha b lockers such as alfuzosin (Uroxatral), doxazosin (Cardura), prazosin (Minipress), tam sulosin (Flomax, in Jalyn), silodosin (Rapaflo), and terazosin; certai n antifungal medications such as fluconazole (Diflucan), itraconazole (Onm el, Sporanox), and ketoconazole (Nizoral); aprepitant (Emend); clarithromycin (Biax in, in Prevpac); diltiazem (Cardizem, Cartia, Tiazac); erythromycin (E.E.S, E-Myci n, Erythrocin); HIV protease inhibitors such as atazanavir (Reyataz, in Evotaz ), fosamprenavir (Lexiva), indinavir (Crixivan), nelfinavir (Viracept), ritonavir (N orvir, in Kaletra), and saquinavir (Invirase); other medications or treatments for ere ctile dysfunction; medications for high blood pressure; nefazodone; verapamil (Ca lan, Covera, Verelan, others); and telithromycin (Ketek). Your doctor may need to change the doses of your medications or monitor you carefully for side ef fects. Many other medications may also interact with avanafil, so be sure to tell your doctor about all the medications you are taking, even those that do not appear o n this list. tell your doctor if you have ever been advised by a doctor to av oid sexual activity for medical reasons, if you have had heart surgery within the pas t 6 months and if you have ever had an erection that lasted longer than 4 hours. A lso tell your doctor if you have or have ever had a condition that affects the shape of the penis such as angulation, cavernosal fibrosis, or Peyronie's disease; a heart attack; a stroke; an irregular heartbeat; a blocked artery; angina (chest pain); hig h or low blood pressure; heart failure; blood cell problems such as sickle cell anemia (a disease of the red blood cells), multiple myeloma (cancer of the plasma c ells), or leukemia (cancer of the white blood cells); ulcers; bleeding problems; or liver or kidney
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While you taking avanafil
You should know this while taking avanafil Tell all of your health care providers that you take this medici ne. This includes your doctors, nurses, pharmacists, and dentists. Avoid driving and doing other tasks or actions that call for yo u to be alert until you see how avanafil affects you. To lower the chance of feeling dizzy or passing out, rise slowl y if you have been sitting or lying down. Be careful going up and down stairs. Do not take this medicine with other drugs used to treat a change in sex ability. If you drink grapefruit juice or eat grapefruit often, talk with yo ur doctor. Talk with your doctor before you drink alcohol. This medicine does not stop the spread of diseases like HIV or h epatitis that are passed through blood or having sex. Do not have any kind of sex without using a latex or polyurethane condom. Do not share needles or other th ings like toothbrushes or razors. Talk with your doctor.
disease. Also tell your doctor if you have or have ever had reti nitis pigmentosa (a rare inherited eye disease) or if you have ever had severe vision l oss, especially if you were told that the vision loss was caused by a blockage of bl ood flow to the nerves that help you see. you should know that avanafil is only for use in males. Women s hould not take avanafil, especially if they are or may become pregnant or are bre astfeeding. If a pregnant woman takes avanafil, she should call her doctor. talk to your doctor about the safe use of alcoholic beverages d uring your treatment with avanafil. If you drink a large amount of alcohol (more than th ree glasses of wine or three shots of whiskey) while you are taking avanafil yo u are more likely to experience certain side effects of avanafil such as dizziness , headache, fast heartbeat, and low blood pressure. if you are having surgery, including dental surgery, tell the do ctor or dentist that you are taking avanafil. you should know that sexual activity may be a strain on your hea rt, especially if you have heart disease. If you have chest pain, dizziness, or nausea during sexual activity, call your doctor immediately and avoid sex ual activity until your doctor tells you otherwise. tell all your healthcare providers that you are taking avanafil . If you ever need emergency medical treatment for a heart problem, the healthcare providers who treat you will need to know when you last took avanafil.
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After you taking avanafil
A very bad eye problem has rarely happened with avanafil. This may lead to a change in eyesight and sometimes loss of eyesight, which may not come back. Talk with the doctor. This medicine is not approved for use in children.
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Keep this medication in the container it came in, tightly clo sed, and out of reach of children. Store it at room temperature and away from excess heat a nd moisture (not in the bathroom). Unneeded medications should be disposed of in special ways t o ensure that pets, children, and other people cannot consume them. However, yo u should not flush this medication down the toilet. Instead, the best way to dis pose of your medication is through a medicine take-back program. Talk to you r pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. It is important to keep all medication out of sight and reach of c hildren as many containers (such as weekly pill minders and those for eye drops, c reams, patches, and inhalers) are not child-resistant and young children can ope n them easily. To protect young children from poisoning, always lock safety cap s and immediately place the medication in a safe location – one that is up and awa y and out of their sight and reach.
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5.Dosage of Avanafil powder
For oral dosage form (tablets):
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Avanafil comes as a tablet to take by mouth. For men taking the 100- mg or 200-mg doses, avanafil is usually taken with or without food as needed, abo ut 15 minutes before sexual activit,no more than once a day,.
For men taking the 50-mg dose, avanafil is usually taken with o r without food as needed,about 30 minutes before sexual activity. Do not take avanafil more often than once in 24 hours.
Children—Use is not recommended.
The dose of this medicine will be different for different patie nts. Follow your doctor's orders or the directions on the label. The following information includes only the average
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doses of this medicine. If your dose is different, do not chang e it unless your doctor tells you to do so.
The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between do ses, and the length of time you take the medicine depend on the medical problem for wh ich you are using the medicine.
6.Warning of Avanafil
Concerns related to adverse effects:
• Color discrimination: May cause dose-related impairment of c olor discrimination. Use caution in patients with retinitis pigmentosa; a minority hav e genetic disorders of retinal phosphodiesterases (no safety information available).
• Hearing loss: Sudden decrease or loss of hearing has been report ed rarely; hearing changes may be accompanied by tinnitus and dizziness. A dire ct relationship between therapy and hearing loss has not been determined.
• Hypotension: Decreases in blood pressure may occur due to vaso dilator effects; use with caution in patients with left ventricular outflow obstr uction (aortic stenosis or hypertrophic obstructive cardiomyopathy); may be more sensitiv e to hypotensive actions. Concurrent use with alpha-adrenergic antagonist therapy may cau se symptomatic hypotension; patients should be hemodynamically stable pri or to initiating therapy at the lowest possible dose. Patients should avoid or limit concurre nt substantial ethanol consumption as this may increase the risk of symptomatic hypot ension.
• Priapism: Painful erection >6 hours in duration has been report ed (rarely). Instruct patients to seek immediate medical attention if erection per sists >4 hours. Use with caution in patients who have conditions which may predispose them to priapism (sickle cell anemia, multiple myeloma, leukemia).
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7.What Are the PossibleSide Effects of Avanafil?
What side effects can this medication cause?
Avanafil may cause side effects. Tell your doctor if any of th ese symptoms are severe or do not go away:
headache
flushing
back pain
Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately or get emergency medical treatment:
an erection that lasts longer than 4 hours
sudden loss of vision in one or both eyes (see below for more info rmation)
sudden hearing loss (see below for more information)
ringing in the ears
dizziness
rash
itching
swollen eyelids
Avanafil may cause other side effects. Call your doctor if yo u have any unusual problems while taking this medication.
8.Avanafil Compared to Viagra and Cialis for ED Treatment
If you have erectile dysfunction and are looking at Avanafil co mpared to Viagra and Cialis then read on. If you are among the estimated 30 million men in the United States who
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experience erectile dysfunction and you want to take one of the erectile dysfunction drugs, the recent approval of Avanafil by the Food and Drug Administrat ion (FDA) means you now have five drugs from which to choose. Is Avanafil your best c hoice because it is the newest drug? How does Avanafil compare with other drugs for erect ile dysfunction? And most important, how effective is Avanafil compared to Viagra a nd Cialis?
The Five Erectile Dysfunction Drugs
The five FDA-approved erectile dysfunction drugs on the market a re avanafil (Stendra), sildenafil (Viagra), tadalafil (Cialis), andvardenafil(both Levitra and Staxyn, an orally dissolving form of Levitra). All of these drugs belong to the same drug class known as phosphodiesterase (PDE) inhibitors because they all work by blo cking the enzyme phosphodiesterase type 5 (PDE-5).
When PDE-5 is blocked, this increases blood flow to the penis, which in turn will, in most cases, result in an erection. We say “most cases” because the eff icacy of all five drugs are similar, depending on the dose taken, and average about 77% to 8 4%.
Avanafil for Erectile Dysfunction
Because Avanafil is the newest addition to the arsenal of erect ile dysfunction drugs, let’s take a closer look at it before we do a comparison with the other ED drugs. In clinical trials, overall 77% of men with general erectile dysfunction who took Av anafil achieved an erection compared with 54% of men who took placebo. Among men wi th erectile dysfunction related to diabetes, 63% achieved an erection aft er taking Avanafil compared with 42% who took placebo.
Let’s look at the results of one 12-week Phase III trial in partic ular. A total of 646 men were randomly assigned to take either 50, 100, or 200 mg of avanafil 30 minutes before initiating sexual activity. There were no restrictions on food o r alcohol use. Of the 300 sexual attempts made during the study, 64% to 71% were successf ul among men who took avanafil compared with 27% among men who took placebo. Ot her good news: 59% to 83% of the 80 attempts at sexual intercourse made more than 6 h ours after taking Avanafil were successful compared with only 25% successful at tempts in men who took placebo. In some men, Avanafil worked in as little as 15 minute s. (Goldstein 2012)
In fact, one thing that may separate Avanafil from the other fou r ED drugs is how fast it works. Dr. Wayne Hellstrom, professor of urology at Tulane Univers ity School of Medicine in New Orleans, stated in a Reuters article that Avanafil “is pot entially the fastest acting of
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the four,” as clinical trials have shown it can work as fast as 15 m inutes. However, there have been reports of Cialis working in about 15 minutes as well.
9.How Fast Do ED Drugs Work?
Some erectile dysfunction drugs work faster than others, and foo d can be a contributing factor (Avanafil Compared to Viagra and Cialis):
Cialis: 15 to 45 minutes, food has no effect Levitra and Staxyn: 25 minutes, but can be delayed if taken wit h a fatty meal Avanafil: 30 minutes, food not believed to have an effect Viagra: 30 minutes, but can be delayed if taken with food
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10.How Long Do ED Drugs Last? (Avanafil Compared to Viagra and Cialis) The erectile dysfunction drugs differ in how long a man can expe ct to be able to achieve an erection. Actual times can vary, depending on the dose taken and other factors.
Cialis: 36 hours Levitra and Staxyn: 4 to 5 hours Avanafil: more than 6 hours in some patients Viagra: 4 to 5 hours
11.Side Effects of ED Drugs
Although the side effects associated with all of the ED drugs a re somewhat similar, there are differences that may be important to some men.
Cialis: Most common are headache and indigestion. Less commo n are back pain, dizziness, facial flushing, muscle aches, nasal congestio n. Levitra and Staxyn: Most common are facial flushing and headac he. Less common are dizziness, indigestion, nasal congestion, nause a. Avanafil: Most common are flushing, headache, nasal conges tion, and runny nose. Less common are back pain, diarrhea, dizziness, hypertension, i nfluenza, muscle aches, and upper respiratory infection. Viagra: Most common are facial flushing, headache, indigesti on. Less common are altered vision, diarrhea, dizziness, nasal congestion, ras h, and urinary tract infection.
12.Rare Side Effects of All ED Drugs
All five erectile dysfunction drugs may cause rare side effects t hat include a sudden loss of vision in one or both eyes, sudden loss of hearing in one or bo th ears, and color vision changes. If you experience any of these side effects, contact your healthcare provider immediately.
Another rare side effect is priapism, or a 4 hour erection. Men who experience an erection that lasts 4 hours or longer should seek immediate medical at tention.