Dose response modeling using linear splines [Elektronische Ressource] / vorgelegt von Martin Kappler

Martin Kappler

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• Gesundheit

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• Publié par: universitat_duisburg-essen
• Publié le: 01 janvier 2007
• Nombre de lectures: 17
• Langue: Deutsch
• Poids de l'ouvrage: 1 Mo

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MartinMediziniscderhehFnakult?tinderhUnivuersit?tvDuisburg-Essen2007AusMedizindemMeInstitutFf?rersit?tMediziniscsbuheorgelInformatik,Dipl.BiometrieausunhaftendderEpidemiologiedurcDose-RespdieonsediziniscMoedelingakult?tUsingUnivLineaDriSplinesrg-EsseInauguralVDissertationegtzuronErlangungStat.desKapplerDoktorgradesBerlinderNaturwissenscD?sseldorfDekFan:3.HerrPriv.-Doz.Univ.-Prof.mDr.2007K.-H.aJU.?agchenkbelter:1.rGutacuhDr.ter:Kr?mer,HerrTProf.derDr.?ndlicM.Pr?fung:Neuh?userDezem2.erGutachB.Aeect.partSeidel,ofn,theC.,presentotUM),wescorkH.PhA.,aonseswithb*equallyeenmedizin,published[orM.,hasRo?bacbT.,eenerg,submittedJ.,inT.theofollohwingex-journals:Prev.,Kappler,MedicineM.,eitsmedizin,Pwesc,h,]B.,B.,Marczynski,K.,B.,Preuss,Rihs,B.,H.PW.,S.,Angerer,herenJ.,AScH.U.,heren,banderg,DM.,delingAexpdams,olycyclicA.,carbSeidel,ersA.,osureWilhelm,Epidem.M.,andtributedBr?ning(DGAT.Arb(2006):SozialDose-respUmonseeltmedizirelation41of108.externalgermanandPinh*,ternalKappler*,eStraif,xpMarczynski,osure,andR.,geh,nRihs,o.,teiss,oRabstein,xicPierl,eectsScinbwM.,orkdams,ersK?erlein,withAngerer,expWilhelmosureM.,toA.PBr?ning,AH.(2007):Proose-respceemodingsofofccupationaltheosure46ptharomaticMeetingydroofonsthebiomarkGermanofSopcietandyCancerforBiomar.Occupational16and1863-1873.Enconvironmen3talE.Aarlxluseful.mo.delssomeaerGeorgeePwrBoong,4but.Contentsolyn1.Intro.du.cti.o.n.7.2.Material.and.Metho.ds.10ariance2.1.PaikolycyclicInformationAromaticthHydro.carb24on.S.tudy......dels.......2.6.....................and......10.2.1.1.BacFkground........A.........2.5.......................2.6.2.......24.opulation.....24........10Exp2.1.2.Conduct.of3.2the.Stud.y............16.ctional.mials...............17.e...................of10Linear2.1.3.Determination.of.Occupational.Exp.osuredelto.Airb.orne.P.AHs........2.6.1.Information..11.2.1.4.Determination.of.P.AHyMetabterionolites,.Cotinine,.and.Creatinine.in.Urine311Description2.2StudySplines............Description.................Airb.s.Metab.........onse...............28...................2.312ra2.2.1PBasisoof.the.Space.of.S.plines......................2.4.dditiv.Mo......................12.2.2.1.1.T.runcated.P.o.w19erAnalysisBasisV.and.Regression...................21.Mo.Comparison..............13.2.2.1.2.B-Splines..............21.Ak.e.Criterion.......................22.Ba.esian.Cri........14.2.2.1.3.Double.T.runcated.Lin.ea.r23BasisResults.3.1.of.e.P.........................3.1.115.2.2.2.Regression.Splines............................3.1.2.orne.o.ure.Urinary.olites...............26.Dose-Resp.Analysis16.2.2.3.Knot.Selection........................5..Con38tenPts.3.2.1ListAnalysis.of.V.ariancey.unctions.3.2.4.2.......del...4.Abb.Double.r...osure.....e.................Conclusions.Bibliography.of.App28o3.2.2BasisLinearInterpRegression6...ransformed...........A.dels...............3.2.6.................45.Summa.Zusammenfassung.List.6531ables3.2.3FiguresLinear68Splinesruncated.er.rm.r.68.of.rameters.....35.Log-T.Exp.....................3.2.5.dditiv.Mo................32.3.2.4.F.ractional.P.olynomials....41.Mo.Comparison.............................44.Discussion.5.55.r.56.56.58.of35reviations3.2.4.1ListUnTtrans66formofed67ExpendixosureA.T.P.w.F.fo.a.fo.Linea.Splines.B.retation.Regression.a.70..of1uIntroneglected.ductiontialMofordelingaanshunknoGreenland,wnarelationofbcriticizedetiwarbitrarilyeendueanofoutcomeunknoandoeraorconparameterstinestigateduousimppredictorThisandaoutcomcommoneproblemlargenotcurvonlyvinlationepidemiologyexp.dsItwithisthecarriedwnoutdeltofordescribdeletoandoftenunderstancandisthwbaceymecandhanismandofOnetheassumptiondepwithinencases.denciesisbhaetcewofeenmisclassicationtheerrorvinariablestheinwquestion.categorizingInandostaccupationalestigatedmedicine,lationsstatisticaleciallymoaradelingeseoftagethenassothecidicultapresentiHooofnprostob7etonwineenosureexternalbandapproacinbternaltdoseandasyw(Greenland,ellrston,ashdose-resp2002;onse2004;relationsyston,btheetthatwconstaneenlevexpcategoriesosureinandofeectbinconductedbiologicalitmonitoringehasebtheecpomedose-respimpFortanthetmeasuremenfortheriskmaassessmenducetinandSiminesthearegulatorybprotitativcessmeasureforolonel,cNumeroushemicalssticalofinconcern.moKnofunctionalwledgecopabproblems,outthetheorstrengthregression.ofhand,thedassoadvciationttingandrelationstheexibleshap.ehand,ofarethein-dose-respoonatsemethofunctionevcanesuppandortinamohealthv-ebasedunicatesettinglossofinformationlimitsanofcarefullyexpvosure.expAnmeasureeasynotstartingepThisoinhtaccompaniedforystatisticalortananalysisdraisksgivisenbbmanyauthorsassuming1995b;aulEiseninearScrelationwbrtz,etSteenlandwDeddens,eenAltmantheRostudied2006).vofariables.criticismsHoswtheevofer,tmaneyelsreasonsthecanseemsbnrealisticemostgivSelectionenthascategorytooundarieswhoftenysomewhatthewhileassumptioncanofvlinearitayinumanyonbestimatedeatransgressed,ee.theg.onsebe.ecauseurthermore,ofinthresholdcategorieseects,tosensitization,tsaturation,oforpredictorinariableoyccupationaltrosettings,dier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