Effect of linkage on the control of inbreeding in selection programmes

Fernández Blanca, Santiago Enrique, Toro, Caballero, Caballero Armando

Description

Selection and mating methods for controlling inbreeding in selection programmes are based on relationships obtained from pedigrees. The efficiency of these methods has always been tested by studies using genetic models of independent loci. However, under linkage the rate of inbreeding obtained from pedigrees can be different from the probability of identity by descent of genes. We simulated a quantitative trait under artificial selection controlled by a large number of genes spread on genome regions of different sizes. A method to control inbreeding based on minimising the average coancestry of selected individuals with a restriction in the loss of selection response, and a mating procedure to control inbreeding were applied. These methods, that use coancestry relationships, were not effective in controlling inbreeding when the genome sizes were smaller than five morgans or so. However, for larger genome sizes the methods were sufficiently efficient. For very tight linkage, methods that utilise molecular information from markers should be used. We finally discuss the effects of the selection of individual major genes on the neutral variability of adjacent genome regions.

Sujets

• Inbreeding
• Effective population size
• Genetic drift
• Zygosity
• BLUP

Informations

• Publié par: biomed
• Publié le: 01 janvier 2000
• Nombre de lectures: 8
• Langue: English

Extrait