Frequency distribution of telomere maintenance mechanisms in soft tissue sarcoma [Elektronische Ressource] / von Petra Sander
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Frequency distribution of telomere maintenance mechanisms in soft tissue sarcoma [Elektronische Ressource] / von Petra Sander

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desFetrarequencyrer.distributionersit?tofdertelomeressertationmaintenanc2010ezurmechanismseinesinhaftensoftgenehmigtetissueonsaDarmstadtrcoma17VDarmstadtomErlangungFGradesacDoktorshNaturwissenscb(Dr.ereicnat.)hDiBiologievderPTSanderecDarmstadthniscDhenUniverReferenagt:uarProf.ung:Dr.derGerhardEngstlerThielEinreicKDezemorreferenTt:26.PDMarkusDr.TRalfderJoachhim10.Riekber2009KagorreferenDisputation:t:JanProf.2010Dr.Ruskin).Der(Aristoteles).h?Erstaunen,chhsteWissenscLohnsindf?rwirunsereerdenBemBeginn?histungendieistsienicFhdadurctwdas,(JohnwDerasallerwirhaftendaf?rdasbdassekDingeommen,wiesondernsinddas,Meinerwamilieas2Contents.Zusammenfassung40/sarcomasAbstract381.1QuanGeneralproIntroAbstractduction.5.1.1.Cancer:ductionGeneraluasp.ects..F...........3D.........(PML.........submitted.sarcomas.........ds......5.1.2.Softgtissue.sarcomas:.An.o.v.erview......v.uclear.role.......Aim.........p.this.TMM.ar........6duction1.2.1.Epidemi.ology.andMaterigenetics..............2.1.5.........of.ages.........Abstract......8621.2.2.Grading.and.staging.ofcalizationssoft.tissue.sarcomascytic.emia.o.and.soft.............329t1.2.3.Therap.y............-.ration.based.37.distribution.soft.pr.38.................In...............38.and12.1.3.Analyzed.soft.tissue.sarcomas..Results.................ussion...............2.2.quan.calizations.y....14.1.3.1.Lip.osarcomas........62.................In...............63.of...........elo1le4k1.3.2nLeibomdiesyNBs)osarcomasits.in.tissue...........................

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Publié par
Publié le 01 janvier 2010
Nombre de lectures 27
Poids de l'ouvrage 7 Mo

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desFetrarequencyrer.distributionersit?tofdertelomeressertationmaintenanc2010ezurmechanismseinesinhaftensoftgenehmigtetissueonsaDarmstadtrcoma17VDarmstadtomErlangungFGradesacDoktorshNaturwissenscb(Dr.ereicnat.)hDiBiologievderPTSanderecDarmstadthniscDhenUniverReferenagt:uarProf.ung:Dr.derGerhardEngstlerThielEinreicKDezemorreferenTt:26.PDMarkusDr.TRalfderJoachhim10.Riekber2009KagorreferenDisputation:t:JanProf.2010Dr.Ruskin).Der(Aristoteles).h?Erstaunen,chhsteWissenscLohnsindf?rwirunsereerdenBemBeginn?histungendieistsienicFhdadurctwdas,(JohnwDerasallerwirhaftendaf?rdasbdassekDingeommen,wiesondernsinddas,Meinerwamilieas2Contents.Zusammenfassung40/sarcomasAbstract381.1QuanGeneralproIntroAbstractduction.5.1.1.Cancer:ductionGeneraluasp.ects..F...........3D.........(PML.........submitted.sarcomas.........ds......5.1.2.Softgtissue.sarcomas:.An.o.v.erview......v.uclear.role.......Aim.........p.this.TMM.ar........6duction1.2.1.Epidemi.ology.andMaterigenetics..............2.1.5.........of.ages.........Abstract......8621.2.2.Grading.and.staging.ofcalizationssoft.tissue.sarcomascytic.emia.o.and.soft.............329t1.2.3.Therap.y............-.ration.based.37.distribution.soft.pr.38.................In...............38.and12.1.3.Analyzed.soft.tissue.sarcomas..Results.................ussion...............2.2.quan.calizations.y....14.1.3.1.Lip.osarcomas........62.................In...............63.of...........elo1le4k1.3.2nLeibomdiesyNBs)osarcomasits.in.tissue...........................1.5.of.he.ject..............16.1.3.3.Syno.vial.Sarcomas......35.Publications.in.repa.and.-.on.thesis.2.1.requency.of.in.tissue.(in.ep.ation).2.1.1............17.1.3.4.Mal.igne.P.eripheral.Nerv.e.Sheath.T.umors2.1.2(MPNST)tro..............18.1.3.5.Mal.ignan.t.Fibrous.Histio.cytoma.(MFH)2.1.3.al.Metho......................19.1.42.1.4T.elomere-main.tenance.mec.hanisms.in.soft.tissue.sarcomas...............22431.4.1DiscT.elomeres:.A.brie.f.insigh.t..................57.3D.eometry-based.tication.colo.in.microscop.Im-..........2.3.1.4.2.T.elomerase.activit.y.as.telomere.length.main.tenance......2.2.1........28.1.4.3.The.alternativ.e.lengthening.of.telomeres.(AL.T)......2.2.2.tro..........29.1.4.4.T.elomere.main.tenance.in.soft.tissue.sarcoma..2.2.3.tication.colo................30.1.4.565Promy.Con.ten.ts.2.2.4.Exp.erimen.tia.l3.1.5resultsge.................es.85.vi.......In.......75.ds.....76..68.2.2.5.Di.scussionfurther...83.Vitae.der...............75.duction...............Mate.and.............Results..69.2.2.6.V.erication.of.the.automated.spremarksoterspdetection.b.y.aGeneralman89ualErkl?analysis?(unpublisherdnungd.data)............................3.1.2.tro....................69.3.Unpublished.additional.exp.eriments3.1.375r3.1alALMethoT-asso.ci.ated.PML.b.o.dies:.Do.es.an.y.PML-isoform.colo3.1.4calize.preferen-.tial.with.telomeres?........................79.Concluding.and.p.ectiv.............4.conclusion.Bibliography.Curriculum.107.rung.m??7593.1.1PromotionsoAbstract109..3DList.of.Figures.1.1.T.elomeretstructure.and.telomere-assoualciated.proteins1-6,.genomic.same.AL.non-tumor.c1.yp.y...Man.sp..25.1.2.Mobdelsinof.G-quadruplex.structuren.AL.Maxim.......as.a...exp.man...t.73.mi-.....telomere-FISH.....2.9.T-p25.1.3ofHyprevothesismosomeof.telomere.length.abn.d.itsbassumedtissueeecyty.calization.......2.15.c5.t.66.of..272.171.4bT.elomerase1asizationrib.on.ucleoproteindetectioncomtersp.lmanex3D.........3.1.AMAXA.............tication.in.e.CGH.2.1028lev1.5shoFersormstoofhrrecom.bination.in.AL.T....56.ciated.dies.samples.....57.ciated.dies.and.58.in.jection.t.s.2.14.yp.c5......29.1.6.Illustration.ofcalizationpc1ost-translationalwmotationdications.of.PMLMan.al.images.program.....of.ot.dieren.men33.1.7.TheResultsPMLcologene.and.its.protein.isoforms72.sp.3.erime.......Comparison.and.detection.ca.y..............33.1.8PMLPrombysubsequenelo.cytic.leuk.emia.n.uclear.b.o.diesviiand.its.man54yIdenfunctionsof.alteration.AL.ositiv.tumors.y34.2.155DierenDierentexpressionexpressionellevtelomeraseelswinvSTSalterationrevealedealedthebcyoTRbandsA.P-assa.y...............44.2.2.Dieren2.11tT-assoexpressionPMLlevoelsiofnon-tumortelomerase.in.STS........2.12.T-asso.PML.o.in.samples.soft.sarcmas.2.13.um45tensit2.3proImagesofofuorescensoftmicroscoptissueimagesarcomas.exhibiting64dierenColottTMMes.to..............46.2.4.Correlation.of.te.lomerase66expressionCololevtelesandtomarkasersellforsegmenALresulT-likse.STS.47.2.52.16Correlationualofnteysislomerase3DexpressionblevtheelPointEdit3Dand.mark.ers.for70ALResultsTman.sp.detection.y.t.eri48ters2.6.No.correlation.b7et2.18wofeenualgenomiccalinstabilitdetectiony.and.telomerase.expression...50.2.7.No.correlation2.19bualetotwofeendierengenomicexpinstabilitny.and.AL.T......2.20.of.ual.automated.ot.of.confo.l51croscop2.8imagesChanges.on.sp.eci.c.c.hromosome.bands.correlates.i.n.v.ersely.with.telom-.erase74expressionGFP-taggedlevisoformselstransfected.y.with.t.................................80..itsList.ofComparisonFigures.3.2.QuanPMLt.i.cation.of.colicaliPMLzation.in.four-c.hannel.3DTmicroscop.y.images..8380G3.3andAutomaticexpressionquan.tication.of.a.four-c.hannel.3D.microscop84ydysfunctionimageossible.......8681.3.4.Expression3.6ofofGFP-taggeFP-taggeddisoformsisoformendogenous5isoformsafterprolestransfection.....................82.3.5.Imm.unouorescence.of4.1eelomericnanddogpenousimpactPML-isoforms..............viii..ListOldofcalizationTlengthsables.1.1.The.six1.10hall.marks.of.cancer81...........t.colo...y.......nomenc.....T.organisms...........Chromosome.ect5aluation1.2.T.ypication68ofhannelsoft.tissue.sarcomas........13.curren.of.........20.sequences.dieren.......elomere......7.1.3.Sp.ecic.translo24cationwithinwithsoftTMMtissue2.2sarcomassignican...........Analyzed.a.uorescence.age............9.1.4.Histopathologic.grading.of.soft.tissue1.8sarcomasand.t.lature.MFHs...................1.9.elomere10and1.5inTNM-classicationtof.soft.tissue.sarcomas....23.T.proteins........................11.1.6.T.ranslation2.1tbandsasignicanbalterationlrespetofor.three52andEvfouroftottcalizationsw.o.grade.system............3.1.colo.of12four-c1.73DStagingmicroscopofim-soft.tissue.sarcomas..................................ix.xListablesofT

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