Influence of manufacturing process parameters on the physical properties of an oil-in-water cream [Elektronische Ressource] = Einfluss der Herstellungsfaktoren auf die physikalischen Eigenschaften einer O-W-Creme / vorgelegt von Anja Großmann

Anja Smith

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• Publié par: eberhard_karls_universitat_tubingen
• Publié le: 01 janvier 2008
• Nombre de lectures: 27
• Langue: English
• Poids de l'ouvrage: 6 Mo

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INFLUENCE OF
MANUFACTURING PROCESS PARAMETERS
ON THE PHYSICAL PROPERTIES OF AN
OIL- IN- WATER CREAM


EINFLUSS DER HERSTELLUNGSFAKTOREN AUF DIE
PHYSIKALISCHEN EIGENSCHAFTEN EINER O/W CREME


D I S S E R T A T I O N

der Fakultät für Chemie und Pharmazie
der Eberhard-Karls-Universität Tübingen

zur Erlangung des Grades eines Doktors
der Naturwissenschaften

2007

vorgelegt von
Anja Großmann
INFLUENCE OF
MANUFACTURING PROCESS PARAMETERS
ON THE PHYSICAL PROPERTIES OF AN
OIL- IN- WATER CREAM


EINFLUSS DER HERSTELLUNGSFAKTOREN AUF DIE
PHYSIKALISCHEN EIGENSCHAFTEN EINER O/W CREME


D I S S E R T A T I O N

der Fakultät für Chemie und Pharmazie
der Eberhard-Karls-Universität Tübingen

zur Erlangung des Grades eines Doktors
der Naturwissenschaften

2007

vorgelegt von
Anja Großmann































Tag der mündlichen Prüfung: 15. November 2007
Dekan: Prof. Dr. L. Wesemann
1. Berichterstatter: Prof. Dr. R. Daniels
2. Berichterstatter: Prof. Dr. K.-J. Steffens









Für meine Familie

Acknowledgements
This PhD-thesis arose from the work of 3 years in the technical-pharmaceutical lab (LTF) in
the INTENDIS Manufacturing S.p.A. production site in Segrate (MI), Italy in cooperation with
my tutors and colleagues Dr. Alessandro Regola, Dr. Fausto Cadei and Dr. Enrico Ceruti
under the guidance of my supervisor Prof. Dr. Rolf Daniels from the Eberhard-Karls-
University of Tübingen, Germany.
My special thanks go to Prof. Dr. Rolf Daniels for his excellent guidance, continuous
support and encouragement during the 3 years of my doctorate. I thank you for your kind
supervision and your indispensable informed advice.
My gratitude goes to Prof. Dr. K.-J. Steffens for performing the second expert’s report.
A great thank goes to Dr. Alessandro Regola for his professionalism and availability during
all our discussions and for his always valuable and constructive comments.
I am very grateful to Dr. Fausto Cadei who has given an indispensable support in all
practical and theoretical issues during the 2 years of this work. Thanks a lot for your precious
time you dedicated for manufacturing the pilot scale batches, for your availability and
linguistic help.
I would like to say thank you to Dr. Enrico Ceruti who accompanied me during the first and
undoubtedly the most difficult year of my PhD-thesis. You were highly motivated and
interested in the topic and gave an enormous help during this period.
Many thanks are due to Dr. Chiara Piacenza and Dr. Matthias Werner. You have been a
great support in all organizational issues which were numerous when I arrived in Milan.
I am grateful to all the people who contributed mentally and practically to this work. This
includes colleagues from the ‘Institut für Pharmazeutische Technologie’, TU Braunschweig
and colleagues from the ‘Institut für Pharmazeutische Technologie’, E.-Karls-Universität
Tübingen.
My great gratitude and acknowledgements are to SCHERING AG for the financial support
during this PhD. In particular I would like to thank Dr. Michael Bock and Dr. Thomas
Wozniewski who gave me this unique opportunity to have had such an interesting and
exceptional experience abroad.