Investigation of variables influencing cognitive inhibition[[Elektronische Ressource]] : from the behavioral to the molecular level = Untersuchung der Einflussgrößen kognitiver Unterdrückung / Alica Christina Dieler. Betreuer: Andreas Fallgatter

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Informations

• Publié par: julius-maximilians-universitat_wurzburg
• Publié le: 01 janvier 2011
• Nombre de lectures: 7
• Langue: English
• Poids de l'ouvrage: 1 Mo

Extrait

Investigation of variables influencing cognitive inhibition: from
the behavioral to the molecular level

Untersuchung der Einflussgrößen kognitiver Unterdrückung: Vom
verhaltensorientierten zum molekularen Ansatz


Doctoral thesis for a doctoral degree
at the Graduate School of Life Sciences,
JuliusMaximiliansUniversität Würzburg
Section Neuroscience

submitted by
Alica Christina Dieler
from
München

Würzburg 2011


















Submitted on: 25072011
Members of the Promotionskomitee:
Chairperson: Professor Dr. Martin J. Müller
Primary Supervisor: Professor Dr. Andreas J. Fallgatter
Supervisor (Second): Professor Dr. Paul Pauli
Supervisor (Third): Professor Dr. Fritz Strack
Supervisor (Fourth): Professor Dr. Erhard Wischmeyer

Date of Public Defence: 11102011
Date of receipt of Certificates:










Table of Content

0. Abstract .............................................................................................................................. 7
1. Introduction and Theory ................................................................................................... 11
1.1. Introduction to Cognitive Inhibition and Memory Suppression .............................. 11
1.2. The Think/NoThink Paradigm (TNT) .................................................................... 12
1.2.1. Development of the TNT by Anderson and Green ............................................ 12
1.2.2. Behavioral Studies: The TNT at the Behavioral Level ...................................... 13
1.2.3. Functional Imaging and Electrophysiological Studies: The Neural
Representation of the TNT ................................................................................. 21
1.3. The Genetics of Memory .......................................................................................... 27
1.3.1. Cyclic AMPResponse Element Binding Protein 1: CREB1 ............................. 27
1.3.2. Potassium Channel, Inwardly Rectifying, Subfamily J, Member 6: KCNJ6 ..... 28
1.4. Introduction to the Methods ..................................................................................... 29
1.4.1. Functional NearInfrared Spectroscopy (fNIRS) ............................................... 29
1.4.1.1. Fundamentals of fNIRS .............................................................................. 29
1.4.1.2. Advantages of fNIRS .................................................................................. 31
1.4.1.3. Limitations of fNIRS .................................................................................. 31
1.4.2. Functional Magnetic Resonance Imaging (fMRI).............................................. 32
1.4.3. Electroencephalography and EventRelated Potentials (EEG and ERP) ........... 33
1.4.4. Transcranial Magnetic Stimulation (TMS) including ThetaBurst Stimulation
(TBS) .................................................................................................................. 34
1.4.4.1. TMS ............................................................................................................ 34
1.4.4.2. TBS ............................................................................................................. 36
1.4.4.3. Limitations of TMS and TBS...................................................................... 37
1.5. Thesis Outline and Research Questions ................................................................... 37
2. Materials and Methods ..................................................................................................... 41
2.1. General Remarks ...................................................................................................... 41
2.2. Pilot Study ................................................................................................................ 42
2.2.1. Sample ................................................................................................................ 42
2.2.2. The TNT ............................................................................................................. 42
2.2.3. FNIRS ................................................................................................................. 43
2.2.4. Data Analysis and Statistics ............................................................................... 44
2.2.4.1. Behavioral Data .......................................................................................... 44
2.2.4.2. FNIRS Data ................................................................................................. 44
2.3. Emotion Study .......................................................................................................... 46
2.3.1. Sample ................................................................................................................ 46
2.3.2. The TNT ............................................................................................................. 46
2.3.3. FNIRS ................................................................................................................. 47
2.3.4. Data Analysis and Statistics ............................................................................... 47
2.3.4.1. Behavioral Data .......................................................................................... 47
2.3.4.2. FNIRS Data ................................................................................................. 47
2.4. FMRI Study .............................................................................................................. 49
2.4.1. Sample ................................................................................................................ 49
2.4.2. The TNT ............................................................................................................. 49
2.4.3. FMRI .................................................................................................................. 49
2.4.4. Data Analysis and Statistics ............................................................................... 49
2.4.4.1. Behavioral Data .......................................................................................... 49
2.4.4.2. FMRI Data .................................................................................................. 49
2.5. TBS Study ................................................................................................................ 52
2.5.1. Sample ................................................................................................................ 52 2.5.2. The TNT ............................................................................................................. 52
2.5.3. FNIRS ................................................................................................................. 53
2.5.4. ERPs ................................................................................................................... 54
2.5.5. TBS ..................................................................................................................... 54
2.5.6. Data Analysis and Statistics ............................................................................... 55
2.5.6.1. Behavioral Data .......................................................................................... 55
2.5.6.2. FNIRS Data ................................................................................................. 55
2.5.6.3. ERP Data ..................................................................................................... 56
2.6. Correlations Between and Interaction of BSI, Psychometric Evaluations and
Functional Imaging Data .......................................................................................... 58
2.6.1. Sample ................................................................................................................ 58
2.6.2. Psychometric Evaluations .................................................................................. 58
2.6.3. Data Analysis and Statistics ............................................................................... 61
2.6.3.1. BSI and Psychometric Data ........................................................................ 61
2.6.3.2. Correlations with Functional Imaging Data ................................................ 62
2.6.3.3. Interaction of BSI and fNIRS data with Psychometric Data ...................... 62
2.7. Genetical Analyses ................................................................................................... 63
2.7.1. Behavioral Data .................................................................................................. 63
2.7.2. FNIRS Data ........................................................................................................ 63
2.7.3. FMRI Data .......................................................................................................... 63
3. Results .............................................................................................................................. 64
3.1. Pilot Study ...........................................................