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Publié par | Thesee |
Nombre de lectures | 22 |
Langue | English |
Poids de l'ouvrage | 5 Mo |
Extrait
THESE DE L‘UNIVERSITE DE LYON
Délivrée par
L’UNIVERSITE CLAUDE BERNARD LYON 1
ECOLE DOCTORALE PHAST
DIPLOME DE DOCTORAT
Présentée à Lyon le 14 octobre 2010
par
Mauro TESTA
Physical measurements for ion range verification in charged particle therapy
Directeur de thèse : M. Chevallier
Jury : M. M. Chevallier Directeur de thèse
M. R. Ferrand
M. F. Haas Rapporteur
M. C. Lacasta
M. J-M. Moreau Président du jury
Mme K. Parodi
M. C. Ray
M. D. Schardt Rapporteur
tel-00566188, version 1 - 15 Feb 2011tel-00556628, version 1 - 17 Jan 2011
tel-00566188, version 1 - 15 Feb 2011tel-00556628, version 1 - 17 Jan 2011
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I
tel-00566188, version 1 - 15 Feb 2011tel-00556628, version 1 - 17 Jan 2011
tel-00566188, version 1 - 15 Feb 2011tel-00556628, version 1 - 17 Jan 2011
Contents
1 Overview .................................................................................................... 3
1.1 Particle radiation therapy.................................................................................. 3
1.2 Prompt -camera for dose verification and ion range monitoring in particle
therapy. ......................................................................................................................... 4
1.3 Outline of the thesis.......................................................................................... 6
2 Radiation therapy: introduction............................................................... 7
2.1 Physical rationale for particle radiation therapy............................................... 8
2.2 Radiobiological rationale for particle radiation therapy................................. 10
2.3 Particle vs conventional radiation therapy: clinical results and cost analysis 12
2.3.1 Clinical results ........................................................................................ 13
2.3.2 Cost analysis........................................................................................... 15
2.4 Current and future ion therapy centers ........................................................... 16
3 Radiation therapy with ion beams ......................................................... 18
3.1 The physics of interaction of ions with matter ............................................... 18
3.1.1 Inverse depth dose profile: stopping of ions in matter ........................... 18
3.1.2 Range scattering ..................................................................................... 20
3.1.3 Lateral scattering .................................................................................... 22
3.1.4 Ion fragmentation: models and fragments.............................................. 23
3.2 The physics of interaction of photons with matter ......................................... 26
3.2.1 Photoelectric effect, Compton scattering, Pair production..................... 26
3.3 The physics of interaction of neutrons with matter ........................................ 30
4 Current and proposed methods for dose verification and monitoring
in particle therapy .......................................................................................... 32
4.1 PET and TOF-PET ......................................................................................... 32
4.1.1 Ion range verification with PET ............................................................. 36
4.2 Prompt photon radiation ................................................................................. 37
4.2.1 Collimated Prompt Gamma Camera....................................................... 41
4.2.1 Compton Camera.................................................................................... 43
4.3 Interaction Vertex Imaging (IVI) ................................................................... 45
5 Physical measurements of the prompt radiation originated from ion
fragmentation ................................................................................................. 48
5.1 Properties of scintillation detectors ................................................................ 48
5.1.1 Characteristics of BaF – NaI(Tl) – LYSO – BC501 scintillators ......... 50 2
and BC501 scintillators..... 54 5.1.2 Pulse shape discrimination (PSD) for BaF2
2415.1.2.1 PSD test measurements with a Am-Be source ................................... 54
5.1.2.2 PSD test measurements with 14 MeV neutrons ..................................... 58
5.2 Measurements of prompt -rays produced from C-ion fragmentation........... 61
5.2.1 GANIL and GSI single-detector experimental set-up ............................ 61
5.2.1.1 Calculation of detection solid angle and field pf view ........................... 64
5.2.2 GANIL multi-detector experimental set-up ........................................... 66
5.3 Results and discussion.................................................................................... 68
5.3.1 GANIL and GSI single-detector experimental results ........................... 68
5.3.1.1 Time of flight (TOF) spectra analysis .................................................... 68
5.3.1.2 Time of flight (TOF) spectra conditioned by PSD................................. 73
5.3.1.3 Photon and neutron scan profiles............................................................ 77
5.3.1.4 TOF-spectra and prompt photon scan profiles comparisons between
measurements and Geant4 Monte Carlo simulations ............................................. 82
5.3.2 GANIL multi-detector preliminary experimental results ....................... 84
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5.3.2.1 Time of flight (TOF) spectra analysis .................................................... 84
5.3.2.2 Multi detector prompt photon scan profiles ........................................... 86
5.4 Conclusions and perspectives......................................................................... 88
6 Geant4 Monte Carlo simulations for the design of a multi-detector
multi-collimator Prompt Gamma Camera..................................................... 92
6.1 Application of Monte Carlo simulation codes in medical physics................. 92
6.1.1 A short overview of the code architecture and physical models used in
Geant4……………………………………………………………………………..93
6.2 Simulations of a simplified multi-collimated and multi-detector Prompt
Gamma Camera .......................................................................................................... 94
6.2.1 Basic principles of collimator design ..................................................... 94
6.2.2 Description of the simulation set-up....................................................... 95
6.2.3 Basic description of collimator imaging properties................................ 99
6.3 Simulations results and discussion ............................................................... 101
6.3.1 Influence of the collimator design on the detection efficiency ............ 101
6.3.1.1 Influence of the collimator thickness and position on the visibility of the
collimator slit-pattern ........................................................................................... 101
6.3.1.2 Influence of the collimator thickness and position on the detection
efficiency ............................................................................................................. 104
6.3.1.3 Influence of the collimator tiles and slit dimension on the detection
efficiency ............................................................................................................. 108
6.3.2 Influence of the collimator design on the spatial resolution................. 109
6.3.2.1 Influence of the collimator position on the spatial resolution .............. 111
6.3.2.2 Influence of the crystal detector width on the spatial resolution.......... 115
6.3.2.3 Influence o