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Modification of the asthma quality of life questionnaire (standardised) for patients 12 years and older

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The age limit for some adult asthma clinical trials has recently been lowered to 12 years. In this study we have made minor modifications to the standardised version of the adult Asthma Quality of Life Questionnaire (AQLQ(S)) to make it valid for patients 12 years and older (AQLQ12+). Methods We have used two clinical trial databases, in which the AQLQ12+ was used, to compare the measurement properties of the questionnaire in patients 12–17 years and patients 18 years and older. A total of 2433 patients (12–75 years), with current asthma and with data that could be evaluated both at randomisation and end of treatment, were included. Results The analysis showed that internal consistency, responsiveness and correlations with other clinical indices were very similar in patients 12–17 years and patients 18 years and older. Conclusion The measurement properties of the AQLQ12+ are similar in adolescents and adults and therefore the instrument is valid for use in adult studies which include children 12 years and older.
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Health and Quality of Life Outcomes
Research Modification of the asthma quality of life questionnaire (standardised) for patients 12 years and older 1 22 Elizabeth F Juniper*, Klas Svensson, AnnChristin Mörkand 2 Elisabeth Ståhl
BioMedCentral
Open Access
1 2 Address: Departmentof Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Canada andAstraZeneca R&D, Lund, Sweden Email: Elizabeth F Juniper*  juniper@qoltech.co.uk; Klas Svensson  Klas.Svensson@astrazeneca.com; AnnChristin Mörk  Ann Christin.Mork@pfizer.com; Elisabeth Ståhl  Elisabeth.Stahl@astrazeneca.com * Corresponding author
Published: 16 September 2005Received: 08 July 2005 Accepted: 16 September 2005 Health and Quality of Life Outcomes2005,3:58 doi:10.1186/1477-7525-3-58 This article is available from: http://www.hqlo.com/content/3/1/58 © 2005 Juniper et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract Background:The age limit for some adult asthma clinical trials has recently been lowered to 12 years. In this study we have made minor modifications to the standardised version of the adult Asthma Quality of Life Questionnaire (AQLQ(S)) to make it valid for patients 12 years and older (AQLQ12+). Methods:We have used two clinical trial databases, in which the AQLQ12+ was used, to compare the measurement properties of the questionnaire in patients 12–17 years and patients 18 years and older. A total of 2433 patients (12–75 years), with current asthma and with data that could be evaluated both at randomisation and end of treatment, were included. Results:The analysis showed that internal consistency, responsiveness and correlations with other clinical indices were very similar in patients 12–17 years and patients 18 years and older. Conclusion:The measurement properties of the AQLQ12+ are similar in adolescents and adults and therefore the instrument is valid for use in adult studies which include children 12 years and older.
Background The Asthma Quality of Life Questionnaire (AQLQ) was developed to measure the functional impairments experi enced by adults 17 years and older [1]. It has 32 items in four domains (symptoms, activity limitations, emotional function and environmental stimuli). In the original AQLQ, five of the activity questions are patientspecific but this proved timeconsuming and troublesome in large clinical trials. To address this problem, we developed the standardised version (AQLQ(S)). In the AQLQ(S) all the activity questions are generic and its measurement prop erties that are almost the same as those of the original
AQLQ [3]. The Paediatric Asthma Quality of Life Ques tionnaire was developed to measure the problems that children 7–17 years experience [2]. It has 23 items in three domains (symptoms, activity limitations and emotional function). Recently, adolescents 12 years and older have been included in adult asthma clinical trials. To avoid using two separate healthrelated quality of life question naires in these studies, we have modified the AQLQ(S) [3] to make it suitable for both adolescents and adults. The AQLQ(S) was selected in preference to the original AQLQ because it is the version of the questionnaire most com monly used in clinical trials.
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