Pattern of distant recurrence according to the molecular subtypes in Korean women with breast cancer

Park, Kim Shinhyuk, Kim Kiho, Yoo Ho, Chae, Bae, Song, Jung

Description

Distant recurrence is one of the most important risk factors in overall survival, and distant recurrence is related to a complex biologic interaction of seed and soil factors. The aim of the study was to investigate the association between the molecular subtypes and patterns of distant recurrence in patients with breast cancer. Methods In an investigation of 313 women with breast cancer who underwent surgery from 1994 and 2000, the expressions of estrogen and progestrone receptor (ER/PR), and human epithelial receptor-2 (HER2) were evaluated. The subtypes were defined as luminal-A, luminal-HER2, HER2-enriched, and triple negative breast cancer (TNBC) according to ER, PR, and HER2 status. Results Bone was the most common site of distant recurrence. The incidence of first distant recurrence site was significantly different among the subtypes. Brain metastasis was more frequent in the luminal-HER2 and TNBC subtypes. In subgroup analysis, overall survival in patients with distant recurrence after 24 months after surgery was significantly different among the subtypes. Conclusions Organ-specific metastasis may depend on the molecular subtype of breast cancer. Tailored strategies against distant metastasis concerning the molecular subtypes in breast cancer may be considered.

Sujets

• Breast disease
• Survival
• Estrogen
• HER2/neu

Informations

• Publié par: biomed
• Publié le: 01 janvier 2012
• Nombre de lectures: 8
• Langue: English

Extrait

Parket al.World Journal of Surgical Oncology2012,10:4 http://www.wjso.com/content/10/1/4

R E S E A R C H

WORLD JOURNAL OF SURGICAL ONCOLOGY

Open Access

Pattern of distant recurrence according to the molecular subtypes in Korean women with breast cancer * Hyung Seok Park, Shinhyuk Kim, Kiho Kim, Ho Yoo, Byung Joo Chae, Ja Seong Bae, Byung Joo Song and Sang Seol Jung

Abstract Background:Distant recurrence is one of the most important risk factors in overall survival, and distant recurrence is related to a complex biologic interaction of seed and soil factors. The aim of the study was to investigate the association between the molecular subtypes and patterns of distant recurrence in patients with breast cancer. Methods:In an investigation of 313 women with breast cancer who underwent surgery from 1994 and 2000, the expressions of estrogen and progestrone receptor (ER/PR), and human epithelial receptor2 (HER2) were evaluated. The subtypes were defined as luminalA, luminalHER2, HER2enriched, and triple negative breast cancer (TNBC) according to ER, PR, and HER2 status. Results:Bone was the most common site of distant recurrence. The incidence of first distant recurrence site was significantly different among the subtypes. Brain metastasis was more frequent in the luminalHER2 and TNBC subtypes. In subgroup analysis, overall survival in patients with distant recurrence after 24 months after surgery was significantly different among the subtypes. Conclusions:Organspecific metastasis may depend on the molecular subtype of breast cancer. Tailored strategies against distant metastasis concerning the molecular subtypes in breast cancer may be considered. Keywords:breast neoplasms, neoplasm metastasis, survival, molecular subtype, estrogen, erbB2

Background Distant recurrence of breast cancer results in poor sur vival outcome and the site of the distant recurrence is also important to predict the clinical outcome [1]. The complex interaction between the primary cancer and metastatic sites includes tumor intravasation, circulation, extravasation, proliferation, and angiogenesis, and the microenvironment of the target tissue, so called“seed and soil”theory, may be associated with organspecific metastasis in cancer patients [2,3]. The advances in the understanding of molecular sub types analyzed by hierarchical clustering using an intrin sic gene list have identified molecular subtypes of breast cancer, and it has been noted that there is a significant difference in survival among the molecular subtypes of

* Correspondence: [e-mail] Department of Surgery, The Catholic University of Korea College of Medicine, Seoul, Korea

breast cancer [4,5]. The predictive and prognostic fac tors including tumor size, nodal status, lymphovascular invasion, estrogen receptor (ER) or progesterone recep tor (PR), and human epithelial receptor 2 (HER2) has been investigated widely concerning molecular subtypes [6]. However, data are limited concerning differences in distant recurrence sites between the breast cancer sub types [7]. Thus, the aim of the study was to investigate whether these subtypes were related to an organspecific metastasis.

Methods Patients Three hundred thirteen women with primary breast cancer who underwent surgery at Seoul St. Mary’s Hos pital between 1994 and 2000 were enrolled in the study. Their medical data were retrospectively analyzed. Clini copathological features including tumor size; nodal

© 2012 Park et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.