Pharmacokinetics of paracetamol (Perfalgan) following different infusion protocols in a porcine model [Elektronische Ressource] / vorgelegt von Sohail Ahmed Sheikh

Sheikh Nefzaoui

Sujets

• Gesundheit

Informations

• Publié par: philipps-universitat_marburg
• Publié le: 01 janvier 2008
• Nombre de lectures: 267
• Langue: Deutsch

Extrait

Aus der Klinik für Anästhesie und Intensivtherapie   Direktor: Prof. Dr. H. Wulf   des Fachbereichs Medizin der Philipps-Universität Marburg     in Zusammenarbeit mit dem Universitätsklinikum Gießen und Marburg GmbH, Standort Marburg       Pharmacokinetics of paracetamol (Perfalgan®) following different infusion protocols in a porcine model.            

 

        Inaugural-Dissertation zur Erlangung des Doktorgrades der gesamten Humanmedizin       dem Fachbereich Medizin der Philipps-Universität Marburg vorgelegt     von Sohail Ahmed Sheikh aus Lahore, Pakistan       Marburg 2008

                                                        Angenommen vom Fachbereich Medizin der Philipps-Universität Marburg am 06.10.2008       Gedruckt mit Genehmigung des Fachbereichs       Dekan: Prof. Dr. med. M. Rothmund Referent: Prof. Dr. med. H. Wulf 1. Korreferent: Prof. Dr. med. T. Gudermann 2. Korreferent: Prof. Dr. rer. nat. Dr. med. J. Krieglstein      

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                                    Meinen Eltern in Liebe und Dankbarkeit        

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

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TABLE OF CONTENTS

   

                 1.INTRODUCTION ………………………………………………7       1.1 Non-opioid analgesics ………………………………………….8        1.2 History…………………………………………………………….10         1.3 Chemical Structure……………………………………………..11       1.4 Indications and applications………………………………….12   1.5 Side effects………………………………………………………13     1.6 Mechanism of action…………………………………………..14     1.7 Pharmacokinetics………………………………………………16     1.8 Current literature………………………………………………..17       1.9 Aim of the trial…………………………………………………..18     2. METHODS ………………………………… ……………………19           2.1 Animals…………………………………………………………..19         2.2 Pre medication and anaesthesia………………………….....19     2.3 Infusion protocol…………………………………………….....19       2.4 Laboratory Methods……………………………………………20     2.4.1 Analytic range………………………………………………. 21         2.4.2 Sensitivity……………………………………………………. 21         2.4.3 Specificity……………………………………………………. 21       2.5 Pharmacokinetics……………………………………………….22    

 

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2.5.1 Pharmacokinetic model…………………………………… 22     2.5.2 Weighting and goodness-of-fit…………………………... 22    2.5.3 Measured parameters……………………………………… 22        3.RESULTS ……………………………………………………….23        3.1 Age, gender and body weights……………………………….23     3.3 Plasma Levels of Paracetamol…………………………….....23     3.3.1 Individual Plasma Levels in 15-min-group…………… .. 23   3.3.2 Individual Plasma Levels in 60-min-group…………… .. 24   3.3.3 Mean Plasma Levels……………………………………….. 24       3.4 CSF Level of Paracetamol…………………………………… .26            3.4.1. Individual CSF Levels in 15-min-group………………… ..26     3.4.2. Individual CSF Levels in 60-min-group…… …………………… 26    3.4.3 Mean CSF Levels……………………………………………………. 27       3.5 Pharmacokinetics  28…………………………… ……………………      4.NCDUISSIOSS    ……………1…………4..………………………         4.1 Summary of the Results……………………………………….41      4.2 Comparison with current literature……………………..... ....41    4.3 Impact of the results…………………………………………....44       4.4 Limitations………………………………………………………..45        4.5 Conclusion and perspectives………………………………...46     5ABSTRACT ………………………………………………………47          6 Reference List ………………………………………..................49      

 

     

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