Population pharmacokinetic analysis for the therapeutic anti-EGFR humanised monoclonal antibody matuzumab [Elektronische Ressource] / von Katharina Küster

Population pharmacokinetic analysis for the therapeutic anti-EGFR humanised monoclonal antibody matuzumab [Elektronische Ressource] / von Katharina Küster

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Population Pharmacokinetic Analysis for the Therapeutic anti-EGFR Humanised Monoclonal Antibody Matuzumab Dissertation zur Erlangung des akademischen Grades doctor rerum naturalium (Dr.rer.nat.) Vorgelegt der Naturwissenschaftlichen Fakultät I Biowissenschaften der Martin"Luther"Universität Halle"Wittenberg von Frau Katharina Küster geb. am 16.01.1979 in Bremen Gutachter: 1. Prof. Dr. Charlotte Kloft 2. Prof. Dr. Karsten Mäder 3. Prof. Dr. HansHubert Borchert Halle (Saale), 30.Januar 2009 urn:nbn:de:gbv:3-000015168[http://nbn-resolving.de/urn/resolver.pl?urn=nbn%3Ade%3Agbv%3A3-000015168] Für meine Familie. Abstract Abstract This thesis aims to contribute to a comprehensive characterisation of the pharmacokinetics (PK) of the novel humanised monoclonal antibody (mAb) matuzumab, targeting the epidermal growth factor receptor, and to a general understanding of mAbs. Concentration"time profiles from 3 clinical studies including 90 study patients (IDs) were analysed simultaneously using the population modelling TMsoftware NONMEM .

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Publié le 01 janvier 2009
Nombre de lectures 16
Langue English
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