Respiratory care : the official journal of the American Association for Respiratory Therapy

American Association For Inhalation Therapy

Sujets

• Respiratory therapy

Informations

• Publié par: les_archives_du_savoir
• Nombre de lectures: 4
• Langue: English
• Poids de l'ouvrage: 11 Mo

Extrait

1
November 1990
1Volume 35, Number
ISSN00989142-RECACP
A MONTHLY SCIENCE JOURNAL
35TH YEAR—ESTABLISHED 1956
PentamidineRibavirin and
Caregiver Beware!Aerosols:Open Forum Abstracts1990
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Two Nebulizers
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Effects of PSVComparison of
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1990November
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1021
"90 No 1• NOVEMBER Vol 35RESPIRATORY CARE) 1
Abstracts Summaries of Pertinent Articles in Other Journals
Reviews, Editorials, and Statements To Note
Delayed Pulmonary Fibrosis after Nitrosourea Therapy (editor-
ial)—AH Limper. JA McDonald. N Engl MedJ 1990:323:407.
(Pertains to the O'Driscoll et al paper abstracted below.)
Utility of Animal Models in the Study of Human Airway Disease
(review)—A Wanner. Chest 1990:98:21 1.
Mucosal Inflammation in Asthma (review)—R Djukanovic, WR
Roche. JW Wilson, et al. Am Rev Respir Dis 1990:142:434.
Lymphocytes in the Lung: Should We Continue To Exalt Only
BALT7 (editorial)—JS Herman. Am J Respir Cell Mol Biol 1990:
3:101.
Is Theophylline Obsolete? (editorial)—MT Newhouse. Chest
1990:98: 1 ( Pertains to theLam and Newhouse
. paper abstracted below.
Theophylline Is No More Obsolete Than "Two Puffs qid" of
Current Beta, Agonists (editorial)—JW Jenne. Chest 1990:98:3.
(Pertains to the Lam and Newhouse paper abstracted below.)
Theophylline Therapy: A Continuing Dilemma (editorial)—DE
Niewoehner. Chest 1990;98:5. (Pertains to Lam and Newhouse paper
abstracted below.)
Active Lung Fibrosis Up to 17 Years fibrosis— within years of treatment revealed2 3 interstitial fibrosis and elas-
after Chemotherapy with Carmus- and 4 from 8 to 13 years after tosis with damage epithelialto and
tine (BCNU) in Childhood BR treatment. This report focuses primar- endothelial cells. Four patients had
O'Driscoll, PS Hasleton, PM Taylor, ily on the 1 1 survivors, 8 of whom symptoms (shortness of breath, cough,
LW Poulter, HR Gattamaneni. AA were available for detailed study 13 or both). Conclusions: Carmustine
Woodcock. N Engl J Med 1990: to 17 years (mean, 14) after treatment. chemotherapy in childhood causes
323:378. Results: Of the 8 survivors studied, 6 lung fibrosis that may remain asymp-
had abnormal chest radiographs show- tomatic for many years or become
Background: Carmustine(BCNU) is an ing predominantly upper-zone fibrotic symptomatic at any time.
anticancer drug known to produce changes. These patients also had
pulmonary fibrosis as a side effect abnormal CT scans, showing a pre-
within 3 years of treatment. It is not viously undescribed pattern of upper-
known whether pulmonary fibrosis can zone fibrosis. All the survivors studied Management ofAsthma and Chronic
appear later. Methods: To investigate had restrictive spirometric defects Airflow Limitation: Are Methylxan-
the clinical range of this side effect, (mean [± SD] vital capacity thines Obsolete? A Lam, MT New-
we studied the survivors among 31 54 ± 19% of the predicted value). house. Chest 1990:98:44.
children treated with carmustine for Bronchoalveolar-lavage fluid con-
brain tumors between 1972 and 1976. tained abnormal proportions ofspecific After almost 50 years as first-line drugs
Fourteen had died of their tumor: