Role of cGMP phosphodiesterases in idiopathic pulmonary fibrosis [Elektronische Ressource] / by Nikolova, Sevdalina Vaskova

Sujets

• Gesundheit

Informations

• Publié par: justus-liebig-universitat_giessen
• Publié le: 01 janvier 2009
• Nombre de lectures: 4
• Langue: English
• Poids de l'ouvrage: 2 Mo

Extrait

Role of cGMP Phosphodiesterases in Idiopathic
Pulmonary Fibrosis
Inaugural Dissertation
submitted to the
Faculty of Medicine
in partial fulfillment of the requirements
for the PhD-Degree
of the Faculties of Veterinary Medicine and Medicine
of the Justus Liebig University Giessen
by
Nikolova, Sevdalina Vaskova
of
Varna, Bulgaria
Giessen 2009From the Department of Medicine
Director / Chairman: Prof. Dr. Werner Seeger
of Medicine of the Justus Liebig University Giessen
First Supervisor and Committee Member: Prof. Dr. Ralph Schermuly
Second Supervisor and Committee Member: Priv.-Doz. Dr. Stephan Rosenkranz
Committee members: Prof. Dr. Ernst Petzinger and Prof. Dr. Susanne Rohrbach
thDate of Doctoral Defense: 16 of March 2009Table of content
Table of content
Table of content··················································································· I
List of figures·····················································································IV
List of tables ·······················································································V
List of abbreviations················································VI
Summary ·····························································································X
Zusammenfassung············································································XI
I. Introduction···························································· 1
1. Idiopathic pulmonary fibrosis (IPF). ·················································· 2
1.1. Classification.···································································································· 3
1.2. Definition.·········································································································· 4
1.3. Histopathology.································································································· 4
1.4. Pathogenesis.··································································································· 5
1.5. Role of AECs in IPF pathogenesis.································································· 10
1.5.1. Morphological characteristics of the alveolar epithelium.························· 10
1.5.2. ATII cells: stem cells of the alveolar epithelium. ······································ 10
1.5.3. ATII cells and alveolar re-epithealization. ················································ 12
1.5.4. Growth factor control of ATII cell proliferation.········································· 13
1.6. Diagnosis and evaluation.·································································· 14
1.6.1. Clinical presentation. ····················································· 14
1.6.2. Diagnosis.·················································································&#