Role of glycosylation in bovine leukemia virus infection

Bouzar Amel-Baya, De, Florins Arnaud, François Carole, Boxus Mathieu, Willems, Willems Luc

Informations

• Publié par: biomed
• Publié le: 01 janvier 2011
• Nombre de lectures: 10
• Langue: English

Extrait

Bouzaret al.Retrovirology2011,8(Suppl 1):A29 http://www.retrovirology.com/content/8/S1/A29

M E E T I N GA B S T R A C TOpen Access Role of glycosylation in bovine leukemia virus infection * AmelBaya Bouzar, Alix de Brogniez , Arnaud Florins, Carole François, Mathieu Boxus, Luc Willems From15th International Conference on Human Retroviruses: HTLV and Related Viruses Leuven and Gembloux, Belgium. 58 June 2011

As a model for HTLV, reverse genetics can be used in the bovine leukemia virus (BLV) system to identify important mechanisms of viral persistence and patho genesis. The question addressed here pertains to the role of glycans bound to the BLV envelope glycoprotein (SU gp51). Addition of carbohydrates to the BLV SU potentially creates a structure called « glycan shield » that confers resistance to the virus against the host immune response. On the other hand, glycosylation can also modulate attachment of the virus to the cell membrane. To unravel the role of SU glycosylation, three comple mentary strategies were developed: pharmacological inhibition of different glycosylation pathways, interfer ence with glycan attachment and sitedirected mutagen esis of Nglycosylation sites in an infectious BLV provirus. Collectively, our results demonstrate that gly cosylation is important for the Gp51 maturation process, for virus infection in vitro and for infectivity in vivo.

Published: 6 June 2011

doi:10.1186/174246908S1A29 Cite this article as:Bouzaret al.:Role of glycosylation in bovine leukemia virus infection.Retrovirology20118(Suppl 1):A29.

* Correspondence: [e-mail] Cellular and Molecular Biology, Gembloux AgroBio Tech, University of Liege, Gembloux, Belgium

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© 2011 Bouzar et al; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.