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Diagnostic Cytopathology Essentials is a succinct yet comprehensive guide to diagnosis in both non-gynecological and gynecological cytology. It provides quick answers to diagnostic problems in the cytological interpretation and recognition of a wide range of disease entities. With content derived from Diagnostic Cytopathology, 3rd Edition, the authoritative reference work by Winifred Gray and Gabrijela Kocjan, Diagnostic Cytopathology Essentials delivers the dependable guidance you need - in a user-friendly format that makes essential facts about any given condition easy to find and apply.

  • Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability.
  • Efficiently review the key cytological features of a broad spectrum of disease entities with more than 1,300 images, consistently presented on opposing pages from the corresponding text summaries for ease of reference.
  • Find the answers you need quickly and easily using an at-a-glance bullet-point format and structure, with every section organized consistently to include Definition, Cytological Findings, and Differential Diagnosis.
  • Streamline decision making and avoid diagnostic pitfalls with the aid of Differential Diagnosis boxes.
  • Improve your diagnostic cytology skills by referencing representative Case Studies throughout.




Publié par
Date de parution 08 mai 2013
Nombre de lectures 1
EAN13 9780702050336
Langue English
Poids de l'ouvrage 14 Mo

Informations légales : prix de location à la page 0,9874€. Cette information est donnée uniquement à titre indicatif conformément à la législation en vigueur.


Diagnostic Cytopathology Essentials
Expert Consult: Online and Print

Gabrijela Kocjan, MD, MB BS, Specialist in Clinical Cytology (Zagreb), FRCPath(London)
Head of Diagnostic Cytopathology, Consultant Cytopathologist, University College London, London, UK

Winifred Gray, MB BS, FRCPath
Consultant Cytopathologist/Histopathologist (retired), John Radcliffe Hospital, Oxford, UK

Tanya Levine, MA(Oxon), MB BS, RCDipPath(Cyto), FRCPath
Director, London Regional Cytology Training Centre, Consultant Cellular Pathologist, North West London Hospitals NHS Trust, London, UK

Ika Kardum-Skelin, MD, PhD, Specialist in Clinical Cytology (Zagreb)
President, European Federation of Cytology Societies, Assistant Professor and Consultant Cytologist, Specialist in Medical/Clinical Cytology, Head of Department of Clinical Cytology and Cytogenetics, Merkur University Hospital, School of Medicine, University of Zagreb, Zagreb, Croatia

Philippe Vielh, MD, PhD
Pathologist, Director of Cytopathology, Department of Medical Biology and Pathology, Institut de Cancérologie Gustave Roussy, Villejuif, France
Table of Contents
Cover image
Title page
List of contributors
Chapter 1: Introduction
Chapter 2: Female genital tract
Normal anatomy of the gynaecological tract (Fig. 2.1)
Cytology of normal cells from the cervical transformation zone
Cytological findings in cervicitis/vaginitis
Common cervical/vaginal microorganisms
Common viral infections
Iatrogenic changes in cervical cytology
Repair and regeneration in the cervix
Cervical sample adequacy
Cytology of CIN and cervical squamous cancer
Borderline nuclear changes in cervical cytology (Figs 2.128–2.136)
Glandular neoplasms in cervical cytology
Management of women with abnormal cervical cytology
Cytology of the vulva and vagina
Uterine cytology
Ovarian cytology
Chapter 3: Respiratory
Normal cytological findings
Reactive changes
Case Study
Common lung tumours
Case Study (Fig 3.73)
Carcinoid tumours
Other lung tumours and metastases
Mesenchymal tumours and lymphomas
Mediastinal tumours
Lung infections
Other pulmonary conditions
Chapter 4: Serous effusions
Cytology of normal and reactive mesothelial cells
Other benign findings in reactive effusions
Benign reactive effusions with specific features
General diagnostic approach to malignant effusions
Diagnostic approach: mesothelioma morphology (Tables 4.5, 4.6)
Diagnostic approach: immunocytochemistry (Fig. 4.86 and Tables 4.7, 4.8)
Chapter 5: Urine cytology
Specimen types and appearances (Figs 5.1–5.9)
Malignancy in urine cytology (Figs 5.19–5.27)
Differential diagnosis in urothelial malignancy
Instrumentation effects (Figs 5.40–5.47)
Chapter 6: Thyroid gland
Introduction (Figs 6.1–6.3)
Benign thyroid nodules
Thyroid hyperplasia/hyperthyroidism
Follicular lesions
Thyroid neoplasms
FNA thyroid reporting categories and their management implications
Chapter 7: Haemopoietic
Normal lymph node
Reactive lymphadenopathy
Neoplastic lesions of lymph node
Myeloid neoplasms
Chapter 8: Breast
The normal breast
Inflammatory conditions
Benign breast changes (Figs 8.24–8.32)
Benign tumours and tumour-like lesions
Epithelial hyperplasia and tumour-like lesions
Complex sclerosing and fibrocystic lesions (Figs 8.59–8.61)
Borderline epithelial lesions (Figs 8.62–8.67)
Common malignant breast epithelial tumours (Table 8.1, Box 8.1)
Uncommon malignant breast epithelial tumours
Primary sarcomas, lymphomas and metastatic tumours (Figs 8.99–8.107)
Reporting breast FNAs: the role of FNA in management
Chapter 9: Salivary gland
Introduction (Figs 9.1–9.3)
Normal salivary gland (Figs 9.4–9.6)
Tumours of the salivary gland
Non-neoplastic conditions
Salivary gland cysts
Diagnostic approach to salivary gland FNA
Chapter 10: Liver, biliary tree and pancreas
Gall bladder and extrahepatic bile ducts
The role of FNA in management of pancreatic lesions
Chapter 11: Childhood tumours
Nephroblastoma (Figs 11.7, 11.8)
Ewing’s (sarcoma) family of tumours (pPNET)
Chapter 12: Miscellaneous
Cerebrospinal fluid
Malignant tumours
Soft tissue and musculoskeletal system
Synovial fluid
Chapter 13: Techniques
Routine procedures
Polymerase chain reaction
In situ hybridisation (ISH) (Figs 13.48, 13.49)
Chapter 14: Self-assessment questions
Subject Index

an imprint of Elsevier Limited
© 2013, Elsevier Limited
First published 2013
The rights of Gabrijela Kocjan, Winifred Gray, Tanya Levine, Ika Kardum-Skelin and Philippe Vielh to be identified as authors of this work has been asserted by them in accordance with the Copyright, Designs and Patents Act 1988.
No part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopying, recording, or any information storage and retrieval system, without permission in writing from the publisher. Details on how to seek permission, further information about the Publisher’s permissions policies and our arrangements with organizations such as the Copyright Clearance Center and the Copyright Licensing Agency, can be found at our website: www.elsevier.com/permissions .
This book and the individual contributions contained in it are protected under copyright by the Publisher (other than as may be noted herein).

Knowledge and best practice in this field are constantly changing. As new research and experience broaden our understanding, changes in research methods, professional practices, or medical treatment may become necessary.
Practitioners and researchers must always rely on their own experience and knowledge in evaluating and using any information, methods, compounds, or experiments described herein. In using such information or methods they should be mindful of their own safety and the safety of others, including parties for whom they have a professional responsibility.
With respect to any drug or pharmaceutical products identified, readers are advised to check the most current information provided (i) on procedures featured or (ii) by the manufacturer of each product to be administered, to verify the recommended dose or formula, the method and duration of administration, and contraindications. It is the responsibility of practitioners, relying on their own experience and knowledge of their patients, to make diagnoses, to determine dosages and the best treatment for each individual patient, and to take all appropriate safety precautions.
To the fullest extent of the law, neither the Publisher nor the authors, contributors, or editors, assume any liability for any injury and/or damage to persons or property as a matter of products liability, negligence or otherwise, or from any use or operation of any methods, products, instructions, or ideas contained in the material herein.
ISBN: 978-0702-04450-2
E-ISBN: 978-0702-05033-6
† The following figures are taken from Gray, W., Kocjan G. (eds). Diagnostic Cytopathology , 3 rd edition. 2010, Churchill Livingstone.
Printed in China
Last digit is the print number: 9 8 7 6 5 4 3 2 1
It gives me great pleasure to see that the idea born at a meeting of European Federation of Cytology Societies (EFCS) in October 2010 in Split, where European Cytology Education and Training were discussed, has come into being in the shape of Diagnostic Cytopathology Essentials . It is a product of the EFCS’ ambition to have a comprehensive, ‘official’ textbook, the contents of which represent a minimum requirement for a competent cytopathologist.
Cytopathology is a diagnostic discipline which has been used for more than 150 years, since Walshe in the middle of the 19 th century demonstrated that cells from lung cancer can be detected in sputum. Another milestone was the introduction of aspiration cytology in 1926 by Ellis and Martin, while in 1928, Papanicolaou published that cells of cervical cancer could be identified by microscopy. However, cytopathology was finally accepted in 1943 when its importance in cervical screening was recognised. From then on, both exfoliative and aspiration cytopathology continued to be recognised as essential in diagnosis and clinical patient management.
In the 21 st century, in the era of modern techniques and shortage of pathologists, does cytopathology still remain an appropriate diagnostic tool? An answer to this question can be found in the Training Charter for Pathology, first published in 2012 by the Union Européenne des Médecines Spécialistes (UEMS), Board of Pathology. The Charter defines cytopathology as an integral part of pathology and its competency has to be trained. It is left to the pathologist to decide under which conditions to use cytopathology, histopathology, or a combination of both, to obtain a correct diagnosis and to evaluate if the resp

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