Hematopathology E-Book , livre ebook

Hematopathology

Elaine S. Jaffe, MD
Chief, Hematopathology Section, Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health; Clinical Professor of Pathology, George Washington University School of Medicine; Series Editor, World Health Organization Classification of Tumours, 4 th Edition, International Agency for Research on Cancer, Bethesda, Maryland

Nancy Lee Harris, MD
Editor, Case Records of the Massachusetts General Hospital, New England Journal of Medicine, Austin L. Vickery Professor of Pathology, Harvard Medical School; Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts

James W. Vardiman, MD
Professor and Director of Hematopathology, Department of Pathology, University of Chicago School of Medicine, Chicago, Illinois

Elias Campo, MD
Chief, Hematopathology Unit, Professor of Anatomic Pathology, Clinical Director, Center for Biomedical Diagnosis, Hospital Clinic, University of Barcelona, Barcelona, Spain

Daniel A. Arber, MD
Professor and Associate Chair of Pathology, Director of Anatomic Pathology and Clinical Laboratory Services, Stanford University, Stanford, California
Saunders
Front Matter

Hematopathology
Elaine S. Jaffe, MD
Chief, Hematopathology Section
Laboratory of Pathology
Center for Cancer Research, National Cancer Institute
National Institutes of Health;
Clinical Professor of Pathology
George Washington University School of Medicine;
Series Editor, World Health Organization Classification of Tumours, 4 th Edition
International Agency for Research on Cancer
Bethesda, Maryland
Nancy Lee Harris, MD
Editor, Case Records of the Massachusetts General Hospital
New England Journal of Medicine
Austin L. Vickery Professor of Pathology
Harvard Medical School;
Department of Pathology
Massachusetts General Hospital
Boston, Massachusetts
James W. Vardiman, MD
Professor and Director of Hematopathology
Department of Pathology
University of Chicago School of Medicine
Chicago, Illinois
Elias Campo, MD
Chief, Hematopathology Unit
Professor of Anatomic Pathology
Clinical Director, Center for Biomedical Diagnosis
Hospital Clinic, University of Barcelona
Barcelona, Spain
Daniel A. Arber, MD
Professor and Associate Chair of Pathology
Director of Anatomic Pathology and Clinical Laboratory Services
Stanford University
Stanford, California

Saunders / Elsevier
Philadelphia, PA
Copyright

3251 Riverport Lane
St. Louis, Missouri 63043
Hematopathology ISBN: 978-0-7216-0040-6
Copyright © 2011 by Saunders, an imprint of Elsevier Inc.
No part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopying, recording, or any information storage and retrieval system, without permission in writing from the publisher. Details on how to seek permission, further information about the Publisher’s permissions policies and our arrangements with organizations such as the Copyright Clearance Center and the Copyright Licensing Agency, can be found at our website: www.elsevier.com/permissions .
This book and the individual contributions contained in it are protected under copyright by the Publisher (other than as may be noted herein).
Contributions provided by Elaine S. Jaffe, M.D. to the Work were provided in a personal capacity and do not necessarily represent the opinions or endorsement of the National Institutes of Health, the Department of Health and Human Services, or the Federal Government .


Notices
Knowledge and best practice in this field are constantly changing. As new research and experience broaden our understanding, changes in research methods, professional practices, or medical treatment may become necessary.
Practitioners and researchers must always rely on their own experience and knowledge in evaluating and using any information, methods, compounds, or experiments described herein. In using such information or methods they should be mindful of their own safety and the safety of others, including parties for whom they have a professional responsibility.
With respect to any drug or pharmaceutical products identified, readers are advised to check the most current information provided (i) on procedures featured or (ii) by the manufacturer of each product to be administered, to verify the recommended dose or formula, the method and duration of administration, and contraindications. It is the responsibility of practitioners, relying on their own experience and knowledge of their patients, to make diagnoses, to determine dosages and the best treatment for each individual patient, and to take all appropriate safety precautions.
To the fullest extent of the law, neither the Publisher nor the authors, contributors, or editors, assume any liability for any injury and/or damage to persons or property as a matter of products liability, negligence or otherwise, or from any use or operation of any methods, products, instructions, or ideas contained in the material herein.
Library of Congress Cataloging-in-Publication Data
Hematopathology / [edited by] Elaine S. Jaffe … [et al.].—1st ed.
p. ; cm.
Includes bibliographical references.
ISBN 978-0-7216-0040-6
1. Blood—Pathophysiology. 2. Blood—Diseases—Diagnosis. 3. Hematology. I. Jaffe, Elaine Sarkin.
[DNLM: 1. Hematologic Diseases—pathology. 2. Lymphatic Diseases—pathology. WH 120 H48785 2011]
RB145.H429727 2011
616.1′5—dc22
2009046370
Acquisitions Editor: William Schmitt
Developmental Editor: Andrea Vosburgh
Publishing Services Manager: Debbie Vogel
Senior Project Manager: Jodi Kaye
Project Manager: Bridget Healy
Design Manager: Ellen Zanolle
Illustrations Manager: Mike Carcel
Printed in China
Last digit is the print number: 9 8 7 6 5 4 3 2
Contributors

Andrea Abati, MD, Dermatopathologist Dermpath Diagnostics Port Chester, New York; Einstein College of Medicine Bronx, New York

Daniel A. Arber, MD, Professor and Associate Chair of Pathology Director of Anatomic Pathology and Clinical Laboratory Services Stanford University Stanford, California

Çiğdem Atayar, MD, PhD, Department of Pathology University Medical Centre Groningen Groningen, The Netherlands

Adam Bagg, MD, Professor, Director of Hematology Department of Pathology and Laboratory Medicine University of Pennsylvania; Director of Hematology Director, Minimal Residual Disease Resource Laboratory Department of Pathology and Laboratory Medicine Hospital of the University of Pennsylvania Philadelphia, Pennsylvania

Barbara J. Bain, MBBS, FRACP, FRCPath, Professor, Department of Haematology Imperial College; Professor, Department of Haematology St. Mary’s Hospital London, United Kingdom

Todd S. Barry, MD, PhD, Medical Director Clarient Aliso Viejo, California

Michael J. Borowitz, MD, PhD, Professor of Pathology and Oncology Johns Hopkins Medical Institutions Baltimore, Maryland

Pierre Brousset, MD, Department of Pathology CHU Purpan; Inserm U-563, Department of Oncogenesis and Signaling in Hematopoietic Cells Centre de Physiopathologie de Toulouse-Purpan Toulouse, France

Russell K. Brynes, MD, Professor of Pathology, Department of Pathology University of Southern California Keck School of Medicine; Director of Hematopathology, Department of Pathology Los Angeles County-University of Southern California Medical Center Los Angeles, California

Francisca I. Camacho, MD, PhD, Staff Pathologist, Department of Pathology Hospital Universitario de Getafe; Research Associate, Lymphoma Group, Molecular Pathology Program Spanish National Cancer Research Centre Madrid, Spain

Elias Campo, MD, Chief, Hematopathology Unit Professor of Anatomic Pathology Clinical Director, Center for Biomedical Diagnosis Hospital Clinic, University of Barcelona Barcelona, Spain

Ignacio Chacón, MD, Molecular Pathology Program Centro Nacional de Investigaciones Oncológicas Madrid, Spain; Hospital Virgen de la Salud Toledo, Spain

R.S.K. Chaganti, PhD, Member and Professor, William E. Snee Chair Medicine and Cell Biology Program Memorial Sloan-Kettering Cancer Center New York, New York

Alexander C.L. Chan, MBBS, FRCPA, Consultant Pathologist, Department of Pathology Queen Elizabeth Hospital Hong Kong, China

John K.C. Chan, MBBS, FRCPath, Consultant Pathologist, Department of Pathology Queen Elizabeth Hospital Hong Kong, China

Wing C. (John) Chan, MD, Amelia and Austin Vickery Professor of Pathology Co-Director, Center for Lymphoma and Leukemia Research University of Nebraska Medical Center Omaha, Nebraska

Karen L. Chang, MD, Director of Clinical Pathology, Department of Pathology City of Hope National Medical Center Duarte, California

Wah Cheuk, MBBS, FRCPA, Associate Consultant, Department of Pathology Queen Elizabeth Hospital Hong Kong, China

Joseph M. Connors, MD, Clinical Professor and Clinical Director Centre for Lymphoid Cancer British Columbia Cancer Agency University of British Columbia Vancouver, British Columbia, Canada

Fiona E. Craig, MD, Associate Professor, Department of Pathology University of Pittsburgh School of Medicine; Staff Pathologist Medical Director, Clinical Flow Cytometry Laboratory Division of Hematopathology, Department of Pathology U