Leibel and Phillips Textbook of Radiation Oncology - E-Book , livre ebook

Leibel and Phillips Textbook of Radiation Oncology
Third Edition

Richard T. Hoppe, MD, FACR, FASTRO
Henry S. Kaplan—Harry Lebeson Professor in Cancer Biology and Chair, Department of Radiation Oncology, Stanford University School of Medicine, Stanford, California

Theodore Locke Phillips, MD, FACR, FASTRO
Professor of Radiation Oncology, Department of Radiation Oncology, University of Arizona, Tucson, Arizona;, University of California, Davis, Sacramento, California

Mack Roach, III, MD, FACR
Professor and Chairman, Department of Radiation Oncology, University of California, San Francisco, San Francisco, California
Saunders
Front Matter

Leibel and Phillips Textbook of Radiation Oncology
THIRD EDITION
Richard T. Hoppe, MD, FACR, FASTRO
Henry S. Kaplan–Harry Lebeson Professor in Cancer Biology and Chair
Department of Radiation Oncology
Stanford University School of Medicine
Stanford, California
Theodore Locke Phillips, MD, FACR, FASTRO
Professor of Radiation Oncology
Department of Radiation Oncology
University of Arizona
Tucson, Arizona;
University of California, Davis
Sacramento, California
Mack Roach, III, MD, FACR
Professor and Chairman
Department of Radiation Oncology
University of California, San Francisco
San Francisco, California
With 1623 illustrations
Copyright

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LEIBEL AND PHILLIPS TEXTBOOK OF RADIATION ONCOLOGY ISBN: 978-1-4160-5897-7
Copyright © 2010, 2004, 1998 by Saunders, an imprint of Elsevier Inc.
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Notices
Knowledge and best practice in this field are constantly changing. As new research and experience broaden our understanding, changes in research methods, professional practices, or medical treatment may become necessary.
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With respect to any drug or pharmaceutical products identified, readers are advised to check the most current information provided (i) on procedures featured or (ii) by the manufacturer of each product to be administered, to verify the recommended dose or formula, the method and duration of administration, and contraindications. It is the responsibility of practitioners, relying on their own experience and knowledge of their patients, to make diagnoses, to determine dosages and the best treatment for each individual patient, and to take all appropriate safety precautions.
To the fullest extent of the law, neither the Publisher nor the authors, contributors, or editors, assume any liability for any injury and/or damage to persons or property as a matter of products liability, negligence or otherwise, or from any use or operation of any methods, products, instructions, or ideas contained in the material herein.
Library of Congress Cataloging-in-Publication Data
Leibel and Phillips textbook of radiation oncology / [edited by] Theodore Locke Phillips, Richard T. Hoppe, Mack Roach, III.—3rd ed.
p. ; cm.
Other title: Textbook of radiation oncology
Rev. ed. of: Textbook of radiation oncology / [edited by] Steven A. Leibel, Theodore L. Phillips. 2nd ed. c2004.
Includes bibliographical references and index.
ISBN 978-1-4160-5897-7 (hardcover : alk. paper) 1. Cancer–Radiotherapy. 2. Medical physics. 3. Tumors–Radiography. 4. Radioisotope brachytherapy. I. Phillips, Theodore L. II. Hoppe, R. (Richard) III. Roach, Mack. IV. Leibel, Steven A. V. Textbook of radiation oncology. VI. Title: Textbook of radiation oncology.
[DNLM: 1. Neoplasms–radiotherapy. 2. Health Physics–methods. 3. Radiation Oncology–methods. QZ 269 L525 2010]
RC271.R3T45 2004
616.99′40642–dc22
2010017535
Acquisitions Editor: Dolores Meloni
Senior Developmental Editor: Janice M. Gaillard
Publishing Services Manager: Catherine Jackson
Senior Project Manager: Rachel E. McMullen
Design Direction: Louis Forgione
Printed in China
Last digit is the print number: 9 8 7 6 5 4 3 2 1
Contributors

Andre Abitbol, MD, Associate Director Department of Radiation Oncology Baptist Hospital Miami, Florida

David H. Abramson, MD, Chief, Ophthalmic Oncology Service Department of Surgery Memorial Sloan-Kettering Cancer Center New York, New York

Ranjana Advani, MD, Associate Professor of Medicine Division of Oncology Stanford University Medical Center Stanford, California

Mohammed Ahmed, MBBS, Kurnool Medical College Kurnool, Andhrapradesh, India

Oguz Akin, MD, Assistant Professor of Radiology, Weill Medical College of Cornell University Attending Radiologist, Memorial Sloan-Kettering Cancer Center Department of Radiology Memorial Sloan-Kettering Cancer Center New York, New York

Kaled M. Alektiar, MD, Associate Attending Radiation Oncologist Department of Radiation Oncology Memorial Sloan-Kettering Cancer Center New York, New York

Michael Alvarado, MD, Assistant Professor of Surgery Department of Surgery University of California, San Francisco San Francisco, California

Howard I. Amols, PhD, Chief, Clinical Physics Service Medical Physics Memorial Sloan Kettering Cancer Center New York, New York

John G. Armstrong, MD, FRCPI, Professor of Radiation Oncology Consultant Radiation Oncologist & Director of Research St. Luke’s Institute of Cancer Research St. Luke’s Hospital Dublin, Ireland

Barbara L. Asselin, MD, Associate Professor of Pediatrics and Oncology Department of Pediatrics University of Rochester School of Medicine Golisano Children’s Hospital at URMC Rochester, New York

Igor J. Barani, MD, Assistant Professor In-Residence Department of Radiation Oncology University of California, San Francisco San Francisco, California

Christopher A. Barker, MD, Resident Department of Radiation Oncology Memorial Sloan-Kettering Cancer Center New York, New York

Luc Beaulieu, PhD, Associate Professor and Head of Medical Physics Research Department of Physics, Physics Engineering and Optics Université Laval Department of Radiation Oncology Centre Hospitalier Universitaire de Québec Québec, Canada

Joel S. Bedford, DPhil, Professor Environmental and Radiological Health Sciences Colorado State University Fort Collins, Colorado

Adrian C. Begg, PhD, Professor, Senior Scientist, Group Leader Experimental Therapy The Netherlands Cancer Institute Amsterdam, The Netherlands

Søren M. Bentzen, PhD, DSc, Professor of Human Oncology; Medical Physics; Biostatistics and Medical Informatics Department of Human Oncology University of Wisconsin School of Medicine and Public Health Madison, Wisconsin

Alison Bevan, MD, PhD, Attending Radiation Oncologist Radiation Oncology Centers Radiological Associates of Sacramento Sacramento, California

Luc M. Bidaut, PhD, Director, Image Processing and Visualization Lab Imaging Physics University of Texas, M.D. Anderson Cancer Center Houston, Texas

Eleanor A. Blakely, PhD, Senior Staff Biophysicist Life Sciences Division Lawrence Berkeley National Laboratory Berkeley, California

J. Martin Brown, DPhil, Professor Radiation Oncology Stanford University Stanford, California

Chandra M. Burman, PhD, Attending Physicist Department of Medical Physics Memorial Sloan-Kettering Cancer Center New York, New York

Oren Cahlon, MD, Attending Physician Princeton Radiation Oncology Center Jamesburg, New Jersey

Matthew D. Callister, MD, Assistant Professor of Oncology Department of Radiation Oncology, Mayo Clinic Arizona Scottsdale, Arizona

Peter Carroll, MD, MPH, Professor and Chair Department of Urology University of California, San Francisco Comprehensive Cancer Center San Francisco, California

Joseph R. Castro, MD, FACR, Professor of Radiation Oncology, Emeritus Department of Radiation Oncology University of California Medical Center San Francisco, California

Daniel T. Chang, MD, Assistant Professor Department of Radiation Oncology Stanford University Stanford, California

Susan M. Chang, MD, Professor, Director of Division of Neuro-Oncology Department of Neurological Surgery University of California, San Francisco San Francisco, California

Devron H. Char, MD, President, Tumori Foundation, Clinical Professor Department of Ophthalmology Stanford University San Francisco, California

Allen M. Chen, MD, Assistant Professor in Residence, Director of Research Department of Radiation Oncology University of California, Davis, Cancer Center Sacramento, Californ