Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases E-Book

Martin J. Blaser, Raphael Dolin, John E. Bennett

Description

After thirty five years, Mandell, Douglas, and Bennett’s Principles and Practice of Infectious Diseases, 8th Edition is still the reference of choice for comprehensive, global guidance on diagnosing and treating the most challenging infectious diseases. Drs. John E. Bennett and Raphael Dolin along with new editorial team member Dr. Martin Blaser have meticulously updated this latest edition to save you time and to ensure you have the latest clinical and scientific knowledge at your fingertips. With new chapters, expanded and updated coverage, increased worldwide perspectives, and many new contributors, Mandell, Douglas, and Bennett’s Principles and Practice of Infectious Diseases, 8th Edition helps you identify and treat whatever infectious disease you see.

• Get the answers to any questions you have with more in-depth coverage of epidemiology, etiology, pathology, microbiology, immunology, and treatment of infectious agents than you’ll find in any other ID resource.
• Apply the latest knowledge with updated diagnoses and treatments for currently recognized and newly emerging infectious diseases, such as those caused by avian and swine influenza viruses.

• Put the latest knowledge to work in your practice with new or completely revised chapters on Influenza (new pandemic strains); New Middle East Respiratory Syndrome (MERS) Virus; Probiotics; Antibiotics for resistant bacteria; Antifungal drugs; New Antivirals for hepatitis B and C; Clostridium difficile treatment; Sepsis; Advances in HIV prevention and treatment; Viral gastroenteritis; Lyme Disease; Helicobacter pylori; Malaria; Infections in immunocompromised hosts; Immunization (new vaccines and new recommendations); and Microbiome.
• Benefit from fresh perspectives and expanded global insights from an expanded team of American and International contributors. Martin Blaser, MD, a leading expert and Muriel G. and George W. Singer Professional of Translational Medicine at New York University School of Medicine, joins veteran PPID editors John E. Bennett, MD, and Raphael Dolin, MD to continue a legacy of excellence.
• Find and grasp the information you need easily and rapidly with newly added chapter summaries.

Informations

• Publié par: Saunders
• Date de parution: 02 septembre 2014
• Nombre de lectures: 3
• EAN13: 9780323263733
• Langue: English
• Poids de l'ouvrage: 11 Mo

Extrait

Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases
Eighth Edition
John E. Bennett, MD, MACP
Adjunct Professor of Medicine, Uniformed Services University of the Health Sciences, F. Edward Hebert School of Medicine, Bethesda, Maryland
Raphael Dolin, MD
Maxwell Finland Professor of Medicine (Microbiology and Molecular Genetics), Harvard Medical School, Boston, Massachusetts
Attending Physician, Beth Israel Deaconess Medical Center, Boston, Massachusetts
Brigham and Women' s Hospital, Boston, Massachusetts
Martin J. Blaser, MD
Muriel G. and George W. Singer Professor of Translational Medicine, Professor of Microbiology, Director, Human Microbiome Program, Departments of Medicine and Microbiology, New York University School of Medicine, Langone Medical Center, New York, New York
Disclaimer
This title includes additional digital media when purchased in print format. For this digital book edition, media content may not be included.
Table of Contents
Cover image
Title page
Copyright
Contributors
Preface to the Eighth Edition
Volume 1
I Basic Principles in the Diagnosis and Management of Infectious Diseases
A Microbial Pathogenesis
1 A Molecular Perspective of Microbial Pathogenicity
Diversity of Human-Microbe Relationships
Attributes of Microbial Pathogens
Clonal Nature of Bacterial Pathogens
Genomics and the Evolution of Pathogenicity
Regulation of Bacterial Pathogenicity
Microbial Pathogens as Intracellular Parasites
Subversion of Host Cellular Processes and Immune Defenses
Identification and Characterization of Virulence Genes
Molecular Microbiology at the Bedside: Pathogen Detection, Pathogen Discovery, and Genomic Profiling
References
2 The Human Microbiome of Local Body Sites and Their Unique Biology
Defining the Human Microbiome
Human Microbiome as a Complex Ecosystem Composed of Multiple Body Site Habitats and Niches
Oral Microbiome
Skin and Nasopharynx
Airway and Pulmonary Microbiome
Gastrointestinal Tract
Vaginal Microbiome
Group B Streptococcus
Alterations in the Vaginal (and Gut) Microbiota during Pregnancy
Summary and Future Directions
References
3 Prebiotics, Probiotics, and Synbiotics
Issues Regarding the Complexity and Variability of Probiotics
Clinical Studies of Probiotics
Proposed Mechanisms of Action of Probiotics
Potential Adverse Effects of Probiotic Therapy
Summary and Future Directions
References
B Host Defense Mechanisms
4 Innate (General or Nonspecific) Host Defense Mechanisms
Natural Physical Barriers to the Entry of Microorganisms Into the Body
Innate Immunity and the Inflammatory Response
Innate Receptor Families
Pathogen Interference with Innate Immune Responses
Other Host Factors Impacting the Host-Pathogen Interaction
References
5 Adaptive Immunity: Antibodies and Immunodeficiencies
Immunoglobulin Structure
Effector Functions Mediated by Antibodies
Kinetics of Antibody Production and Diagnosis of Infections
Laboratory Measurement of Antibodies
B-Cell Maturation and Immunoglobulin Production
Antibody-Mediated Pathology
Immunodeficiencies
Therapeutic Uses of Antibodies
References
6 Cell-Mediated Defense against Infection
T-Cell Subsets and Phenotypic Diversity
T-Cell Activation
Innate Immune Recognition: Setting the Stage for T-Cell Responses
Major Histocompatibility Complex Immunogenetics
Primer on Basic Immunologic Techniques: Foundation of Immunologic Models
Acknowledgment
References
7 Mucosal Immunity
Specialization of Host Responses in Mucosal Tissues
Induction of Mucosal Immune Responses
Role of Mucosal Immunity: Beyond the Mucosa
Conclusions
Acknowledgment
References
8 Granulocytic Phagocytes
Neutrophils
Eosinophils
References
9 Complement and Deficiencies
Complement Synthesis, Catabolism, and Distribution
Complement Activation
Regulation of Complement Activation
Complement Receptors
Families of Complement Proteins
Complement-Mediated Functions
Microbial Interactions with the Complement System
Complement Deficiency States
Complement in Disease States
Evaluation and Treatment of Complement Disorders
References
10 Human Genetics and Infection
Magnitude of the Host Genetic Effect
Diseases
Specific Susceptibility and Resistance Genes
Evolutionary Perspective
Applications
References
11 Nutrition, Immunity, and Infection
Epidemiology of Malnutrition
Malnutrition and Immune Function
Specific Nutrients and Their Roles in Immunity
Overnutrition: Obesity and Infectious Diseases
Special Populations: Clinical Trials of Nutritional Supplementation to Reduce Infection Risk
Host Nutritional Status and Pathogen Virulence
References
12 Evaluation of the Patient with Suspected Immunodeficiency
Index of Suspicion
Initial Evaluation
Lymphocyte Immune Defects
Phagocyte Immune Defects: Neutrophils
Defects Affecting Phagocyte Signaling
Phagocyte and Lymphocyte Defects Affecting Mononuclear Cells
References
C Epidemiology of Infectious Disease
13 Epidemiologic Principles
Epidemiologic Study Methods
Types of Epidemiologic Studies
Host-Agent Relationship
Disease Prevention and Control
References
14 Emerging and Reemerging Infectious Disease Threats
Reemerging Vaccine-Preventable Diseases
Vector-Borne and Zoonotic Diseases
Tick-Borne Diseases
Antimicrobial Resistance
Controlling the Threats
References
15 Bioterrorism: An Overview
History of Biological Weapons
Assessing the Threat and Risk of Biological Weapons
Pathogens of Greatest Concern
Event Detection and Epidemiology
Preparing for and Responding to Biological Weapons
Medical Countermeasures
Dual Use: the Two-Edged Sword of Modern Biology
Acknowledgment
References
D Clinical Microbiology
16 The Clinician and the Microbiology Laboratory
Specimen Selection, Collection, Transport, and Initial Processing
Detection Methods
Identification Methods for Bacteria
Antimicrobial Susceptibility Testing
Mycobacteria
Aerobic Actinomycetes
Fungi
Viruses
Parasites
References
E Anti-infective Therapy
17 Principles of Anti-infective Therapy
Choice of the Proper Antimicrobial Agent
Antimicrobial Combinations
Combinations Against Fungal Pathogens
Disadvantages Associated with Inappropriate Use of Antimicrobial Combinations
Dosages and Evaluation of Efficacy
Summary
References
18 Molecular Mechanisms of Antibiotic Resistance in Bacteria
Molecular Genetics of Antibiotic Resistance
Mechanisms of Antibiotic Resistance
Multidrug-Resistance Mechanisms among Bacteria
Control of Antibiotic Resistance
References
19 Pharmacokinetics and Pharmacodynamics of Anti-infective Agents
Pharmacokinetics
Pharmacodynamics
Conclusion
References
20 Penicillins and -Lactamase Inhibitors
Penicillins
Properties of Individual Penicillins
-Lactamase Inhibitors And Inhibitor Combinations
References
21 Cephalosporins
Chemistry
Classification
Mechanism of Action
Spectrum of Activity
Mechanisms of Resistance
Pharmacologic Properties
Adverse Reactions and Toxicities
Clinical Uses of Specific Drugs
References
22 Other -Lactam Antibiotics
Carbapenems
Carbapenem-Resistant Enterobacteriaceae
Monobactams
References
23 Antibiotic Allergy
Pathophysiology
Diagnosis and Management of Antibiotic Allergy
Tests for IgE-Mediated Immediate Reactions
Procedures to Induce Temporary Drug Tolerance
Drug Allergy to Specific Antimicrobial Agents
References
24 Fusidic Acid
Structure and Mechanism of Action
Antimicrobial Activity
Resistance
Administration and Dosing
Pharmacokinetics and Pharmacodynamics
Adverse Reactions
Clinical Uses
References
25 Aminoglycosides
Chemistry
Mechanisms of Action
Mechanisms of Resistance
Antimicrobial Activity
Clinical Pharmacology
Clinical Indications
Prophylaxis
References
26 Tetracyclines, Glycylcyclines, and Chloramphenicol
Tetracyclines
Glycylcyclines
Chloramphenicol
Acknowledgment
References
27 Rifamycins
Structure and Mechanism of Action
Mechanisms of Resistance
Antimicrobial Activity
Pharmacokinetics
Drug Interactions
Adverse Drug Reactions
Immune-Modulating Effects of Rifampin
Rifamycins for the Treatment of Tuberculosis
Rifamycins for Treatment of Latent Tuberculosis Infection
Rifamycins for Nontuberculous Mycobacterial Infections
Rifamycins for Nontuberculous Mycobacterial Infections
Second-Line Indications for Rifamycins
Rifaximin: a Selective Gastrointestinal Rifamycin
Rifalazil
Rifamycins in Development
References
28 Metronidazole
History
Mechanism