Orthopaedic Pathology
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Orthopaedic Pathology, 5th Edition, by Peter G. Bullough, MB, ChB, presents a unique, lavishly illustrated account of the pathology of arthritic disorders, metabolic disturbances, and soft tissue and bone tumors. Nearly 2,000 high-quality pathologic slides, diagnostic images, and gross specimens-side-by-side-depict the appearance of a wide range of conditions and correlate orthopaedic pathology to clinical practice for greater diagnostic accuracy. It’s the ideal resource for the orthopaedic surgeon and radiologist as well as the trainee and practicing pathologist.

  • Provides extensive coverage of arthritic disorders, metabolic disturbances, soft tissue tumors, bone tumors, and rare disorders-not just tumors, which most books emphasize-for guidance on the most commonly seen conditions.
  • Uses nearly 2000 high-quality illustrations-including pathology, histology, radiologic imaging, and schematic line diagrams-that present a clear visual correlation between pathology and clinical images to aid in diagnosis.
  • Includes a chapter on imaging techniques, interpretation, and strategies that provides a foundation of knowledge in radiology.
  • Features brief text, including bulleted lists of key points and information, that makes reference quick and learning easy.
  • Offers updated coverage of immunohistochemistry and molecular pathology-along with examples from the latest imaging and pathologic techniques-to help you recognize the presentation of disorders using these approaches.
  • Features discussions of some rare conditions, equipping you to diagnose even the least common orthopaedic disorders.


Magnetic resonance imaging
Positron emission tomography
Rheumatoid arthritis
Data storage device
X-ray computed tomography
Tissue (biology)
Back pain
Human skeleton
General practitioner
Internal medicine
Weight loss
Orthopedic surgery
The Corean Chronicles
Ankylosing spondylitis
Ewing's sarcoma
Iron overload
Juvenile idiopathic arthritis
Paget's disease of bone
Human musculoskeletal system
Chronic kidney disease
Hip replacement
Avascular necrosis
Fibrous dysplasia of bone
Chondromalacia patellae
Connective tissue disease
Bone pain
Renal osteodystrophy
Joint replacement
Joint stiffness
Large cell
Aneurysmal bone cyst
Bone disease
Pigmented villonodular synovitis
Hematologic disease
Circulatory collapse
Bone cyst
Hodgkin's lymphoma
Knee pain
Term (time)
Spinal stenosis
Osteogénesis imperfecta


Publié par
Date de parution 08 décembre 2009
Nombre de lectures 0
EAN13 9780323074735
Langue English
Poids de l'ouvrage 16 Mo

Informations légales : prix de location à la page 2,0265€. Cette information est donnée uniquement à titre indicatif conformément à la législation en vigueur.


Orthopaedic Pathology
Fifth Edition

Peter G. Bullough, MB, ChB
Director of Laboratory Medicine, Hospital for Special Surgery
Professor of Pathology and Laboratory Medicine, Weill Medical College of Cornell University, New York, New York
3251 Riverport Lane
Maryland Heights, Missouri 63043
ISBN: 978-0-323-05471-3
© 2010 by Mosby, Inc., an affiliate of Elsevier Inc. All rights reserved.
No part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopying, recording, or any information storage and retrieval system, without permission in writing from the publisher. Details on how to seek permission, further information about the Publisher’s permissions policies and our arrangements with organizations such as the Copyright Clearance Center and the Copyright Licensing Agency, can be found at our website: www.elsevier.com/permissions .
This book and the individual contributions contained in it are protected under copyright by the Publisher (other than as may be noted herein).

Knowledge and best practice in this field are constantly changing. As new research and experience broaden our understanding, changes in research methods, professional practices, or medical treatment may become necessary.
Practitioners and researchers must always rely on their own experience and knowledge in evaluating and using any information, methods, compounds, or experiments described herein. In using such information or methods they should be mindful of their own safety and the safety of others, including parties for whom they have a professional responsibility.
With respect to any drug or pharmaceutical products identified, readers are advised to check the most current information provided (i) on procedures featured or (ii) by the manufacturer of each product to be administered, to verify the recommended dose or formula, the method and duration of administration, and contraindications. It is the responsibility of practitioners, relying on their own experience and knowledge of their patients, to make diagnoses, to determine dosages and the best treatment for each individual patient, and to take all appropriate safety precautions.
To the fullest extent of the law, neither the Publisher nor the authors, contributors, or editors, assume any liability for any injury and/or damage to persons or property as a matter of products liability, negligence or otherwise, or from any use or operation of any methods, products, instructions, or ideas contained in the material herein.
Previous editions copyrighted 2004 by Mosby, Inc., an affiliate of Elsevier Ltd., 1997 by Times Mirror International Publishers Ltd., 1992, 1984 by Gower Medical Publishing Ltd.
Library of Congress Cataloging-in-Publication Data
Bullough, Peter G., 1932-
Orthopaedic pathology / Peter G. Bullough. – 5th ed.
p. ; cm.
Includes bibliographical references and index.
ISBN 978-0-323-05471-3
1. Musculoskeletal system–Diseases–Atlases. I. Title. [DNLM: 1. Bone Diseases–pathology–Atlases.
2. Joint Diseases–pathology–Atlases. 3. Musculoskeletal Diseases–pathology–Atlases. WE 17 B938o 2009]
RC930.4.V54 2009
616.7′071–dc22 2009001328
Acquisitions Editor: William Schmitt
Developmental Editor: Andrea Vosburgh
Design Direction: Steven Stave
Marketing Manager: Brenna Christensen
Printed in China
Last digit is the print number: 9 8 7 6 5 4 3 2 1
This work is dedicated to the memory of my Mother and Father, and by the secretary of the New York Bone Club to its past and present members
Lauren V. Ackerman 1979 – 1993 Robert H. Freiberger 1979 – 2003 Andrew Huvos 1979 – 1996 Alex Norman 1979 – 2004 Hubert A. Sissons 1979 – 1990 Leon Sokoloff 1979 – 1999 German C. Steiner 1979 – Si-Kwang (Sam) Liu 1980 – 2003 Aquilles Villacin 1980 – Leonard B. Kahn 1980 – Julius Smith 1981 – 1988 Howard D. Dorfman 1985 – Michael J. Klein 1994 – Harry Lumerman 1997 – Nogah Haramati 2003 – George Nomikos 2003 – Benjamin Hoch 2003 – 2008 Mark A. Edgar 2003 – 2008
And many more, whose names on Earth are dark,
But whose transmitted effluence cannot die
So long as fire outlives the parent spark,
from Adonais
by Percy Bysshe Shelley (1792 – 1822)

Judith E. Adams, MBBS, FRCF, FRCP, Professor of Diagnostic Radiology and Academic Group Leader, Imaging Science and Biomedical Engineering, University of Manchester, Manchester, UK

Sarah J. Jackson, BMed Sci, BMBS, MRCP, FRCR, Consultant Radiologist, Salford Royal Hospitals NHS Trust, Salford, UK
I graduated from medical school in 1956. At that time, the standard texts in basic orthopaedics, physiology, pathology, and medicine provided little or no information with regard to the pathophysiology of bone and joint disease. Even as late as 1970 when I had the temerity to suggest to the Chief of the Trauma Service at a world famous medical school that perhaps we could learn something from studying bone biopsies from old ladies who had fractured their hips, my suggestion was met with incredulity. Today osteoporosis is recognized as one of the most serious problems facing the aging population.
Our own interest in, and understanding of, disease depends especially upon our teachers and colleagues. In this respect I was most fortunate in being accepted for a residency in anatomic pathology at the Beth Israel Hospital in Boston, where there was a strong tradition of intellectual exchange between the various hospitals and medical schools in the city. This was followed by a two-year fellowship at the Hospital for Joint Disease, New York, with Dr. Henry Jaffe whose whole life had been dedicated to orthopedic pathology in that great institution.
Four years spent in the department of Orthopedic Surgery at the University of Oxford exposed me to one of the most creative and imaginative orthopedic surgeons of his generation, Professor Jose Trueta, as well as two of the brightest young minds of British orthopedics at that time, Mr. Michael Freeman and Mr. John Goodfellow. In 1968 at the invitation of Dr. Philip Wilson Sr., I came to the Hospital for Special Surgery in New York City.
Much of the ever increasing sophistication in the diagnosis of bone and joint disease, I believe, we owe to the foundation in 1972 of the International Skeletal Society, which, for the first time, provided a wider venue for the discussion of the radiographic and histologic diagnosis of bone and joint disease. From its inception this society was interdisciplinary, drawing its members from the leading exponents of radiology, pathology, orthopaedics, and rheumatology in the Americas, Europe, Asia, and Australia. As a result of the annual meetings tremendous progress in diagnostic acumen has been achieved and disseminated through both very successful annual refresher courses offered by the society, and its journal – Skeletal Radiology.
The foundation in 1979 of a local New York Bone Club has provided a level of intellectual fellowship for which I am profoundly grateful. Our monthly meetings over the past 30 years have taught me more of my profession than I would have ever thought possible.
This text was first published in 1984 and was intended to provide a concise, yet lavishly illustrated and comprehensive introduction to the pathology of bone and joint disorders. The target audience was trainees in orthopaedics, radiology, and pathology. Orthopaedic Pathology was one of the early textbooks to be published in full color and this I believe helped to make an understanding of the subject under discussion much more accessible to those whose daily work did not involve the use of the microscope.
Using various imaging techniques, the radiologist may observe the virtual morbid anatomic changes associated with musculoskeletal disease. The histologist in his intent to interpret tissue sections is helped considerably by both clinical and radiologic correlation; without such correlation, serious mistakes are possible. With these thoughts in mind, in the illustration of the conditions under discussion, I have tried to make use of the various imaging techniques now available, and a splendid chapter, written for the nonspecialist by Professor Judith Adams and her colleague Dr. Sarah Jackson, on imaging techniques, interpretation, and strategies is included in the text.
Most of the gross photographs and photomicrographs used in the book were taken over the many years of my professional life. Many of the clinical radiographs are from the Radiology Department at the Hospital for Special Surgery, and I thank all the members of that department for their assistance especially Drs. Robert Freiberger, Robert Schneider, and Douglas Mintz. Additional illustrations have been generously contributed by numerous colleagues throughout the world, mostly members of the International Skeletal Society, to whom I am extremely grateful.
Line drawings have been used to indicate specific features in photographs, and where the three-dimensional or temporal aspects of a structure must be shown, color schematic drawings or anatomic drawings are provided.
The bibliography is arranged by chapter, and subdivided by disease. Nowadays the availability of the internet obviates the need for exhaustive bibliographies. So I have focused on including older references that have been useful to me and that may be less accessible via th

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