Renal Physiology E-Book
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Renal Physiology helps you to quickly and easily grasp the fundamentals of renal physiology and learn how to apply them in a clinical context. Thoroughly updated, this medical reference book in the Mosby Physiology Monograph Series provides a basic understanding of normal kidney function at the cellular and molecular level. Attractively illustrated with clear 2-color diagrams, it also facilitates study with learning objectives, "In the Clinic" and "At the Molecular Level" boxes, chapter summaries, and clinical cases with review questions and explained answers.

  • Stay current with clear, accurate coverage of the physiology of normal renal function focusing on the needs of the student. 
  • Bridge the gap between normal function and disease with pathophysiology content throughout the book. 
  • Understand complex concepts by examining more than more than 250 clear, 2-color diagrams.
  • Perform quick searches ... add your own notes and bookmarks ... and more!
  • Put theory into practice with "In the Clinic" or "At the Molecular Level " boxes in each chapter that explain the practical applications of fundamental knowledge.
  • Deepen your understanding of fundamental and advanced information with an expanded collection of review questions reviewed and reorganized by chapter.
  • Master the material more easily with learning objectives, overview boxes, key words and concepts, and chapter summaries.
  • Apply what you've learned to real-life clinical situations with clinical cases in question-answer format at the end of each chapter.
Gain a quick and easy understanding of the physiology of kidney and renal function



Publié par
Date de parution 12 octobre 2012
Nombre de lectures 0
EAN13 9780323088251
Langue English
Poids de l'ouvrage 4 Mo

Informations légales : prix de location à la page 0,0179€. Cette information est donnée uniquement à titre indicatif conformément à la législation en vigueur.


Renal Physiology
Fifth Edition

Bruce M. Koeppen, MD, PhD
Dean, Frank H. Netter MD School of Medicine, Quinnipiac University, Hamden, Connecticut

Bruce A. Stanton, PhD
Professor of Microbiology and Immunology, and of Physiology, Andrew C. Vail Memorial Professor, The Geisel School of Medicine at Dartmouth, Hanover, New Hampshire
Table of Contents
Cover image
Title page
Mosby Physiology Monograph Series
Chapter 1: Physiology of Body Fluids
Physicochemical Properties of Electrolyte Solutions
Volumes of Body Fluid Compartments
Composition of Body Fluid Compartments
Fluid Exchange between Body Fluid Compartments
Chapter 2: Structure and Function of the Kidneys
Structure of the Kidneys
Chapter 3: Glomerular Filtration and Renal Blood Flow
Renal Clearance
Glomerular Filtration
Renal Blood Flow
Regulation of Renal Blood Flow and Glomerular Filtration Rate
Chapter 4: Renal Transport Mechanisms: NaCl and Water Reabsorption Along the Nephron
General Principles of Membrane Transport
General Principles of Transepithelial Solute and Water Transport
NaCl, Solute, and Water Reabsorption Along the Nephron
Regulation of Nacl and Water Reabsorption
Chapter 5: Regulation of Body Fluid Osmolality: Regulation of Water Balance
Arginine Vasopressin
Renal Mechanisms for Dilution and Concentration of the Urine
Assessment of Renal Diluting and Concentrating Ability
Chapter 6: Regulation of Extracellular Fluid Volumeand NaCl Balance
Concept of Effective Circulating Volume
Volume-Sensing Systems
Control of Renal Nacl Excretion During Euvolemia
Control Of Na+ Excretion with Volume Expansion
Control of Na+ Excretion with Volume Contraction
Chapter 7: Regulation of Potassium Balance
Overview of K+ Homeostasis
Regulation of Plasma [K+]
Alterations of Plasma [K+]
K+ Excretion by the Kidneys
Cellular Mechanisms of K+ Transport by Principal Cells and Intercalated Cells in The Distal Tubule and Collecting Duct
Regulation of K+ Secretion by the Distal Tubule and Collecting Duct
Factors that Perturb K+ Excretion
Chapter 8: Regulation of Acid-Base Balance
Buffer System
Overview of Acid-Base Balance
Renal Net Acid Excretion
Reabsorption Along the Nephron
Regulation of H+ Secretion
Formation of New
Response to Acid-Base Disorders
Simple Acid-Base Disorders
Analysis of Acid-Base Disorders
Chapter 9: Regulation of Calcium and Phosphate Homeostasis
Integrative Review of Parathyroid Hormone and Calcitriol on Ca++ and Pi Homeostasis
Chapter 10: Physiology of Diuretic Action
General Principles of Diuretic Action
Diuretic Braking Phenomenon
Mechanisms of Action of Diuretics
Effect of Diuretics on the Excretion of Water And Solutes
Additional Reading
Appendix A: Integrative Case Studies
Appendix B: Normal Laboratory Values
Appendix C: Nephron Function
Appendix D: Answers to Self-Study Problems
Appendix E: Answers to Integrative Case Studies
Appendix F: Review Examination
Mosby Physiology Monograph Series
Look for these other volumes in the Mosby Physiology Monograph Series:
BLAUSTEIN ET AL: Cellular Physiology and Neurophysiology
HUDNALL: Hematology: A Pathophysiologic Approach
JOHNSON: Gastrointestinal Physiology
LEVY & PAPPANO: Cardiovascular Physiology
WHITE & PORTERFIELD: Endocrine and Reproductive Physiology
CLOUTIER: Respiratory Physiology

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Copyright © 2013 by Mosby, an imprint of Elsevier Inc.
Copyright © 2007, 2001, 1997, 1992 by Mosby, Inc., an affiliate of Elsevier nc.
No part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopying, recording, or any information storage and retrieval system, without permission in writing from the publisher. Details on how to seek permission, further information about the Publisher’s permissions policies and our arrangements with organizations such as the Copyright Clearance Center and the Copyright Licensing Agency, can be found at our website: .
This book and the individual contributions contained in it are protected under copyright by the Publisher (other than as may be noted herein).

Knowledge and best practice in this field are constantly changing. As new research and experience broaden our understanding, changes in research methods, professional practices, or medical treatment may become necessary.
Practitioners and researchers must always rely on their own experience and knowledge in evaluating and using any information, methods, compounds, or experiments described herein. In using such information or methods they should be mindful of their own safety and the safety of others, including parties for whom they have a professional responsibility.
With respect to any drug or pharmaceutical products identified, readers are advised to check the most current information provided (i) on procedures featured or (ii) by the manufacturer of each product to be administered, to verify the recommended dose or formula, the method and duration of administration, and contraindications. It is the responsibility of practitioners, relying on their own experience and knowledge of their patients, to make diagnoses, to determine dosages and the best treatment for each individual patient, and to take all appropriate safety precautions.
To the fullest extent of the law, neither the Publisher nor the authors, contributors, or editors, assume any liability for any injury and/or damage to persons or property as a matter of products liability, negligence or otherwise, or from any use or operation of any methods, products, instructions, or ideas contained in the material herein.
ISBN: 978-0-323-08691-2
Content Development Strategist: William Schmidt
Content Development Specialist: Lisa Barnes
Publishing Services Manager: Patricia Tannian
Project Manager: Carrie Stetz
Design Direction: Steven Stave
Printed in China
Last digit is the print number: 9 8 7 6 5 4 3 2 1
This book is dedicated to our family, friends, colleagues, and, most especially, our students.
When we wrote the first edition of Renal Physiology in 1992, our goal was to provide a clear and concise overview of the function of the kidneys for health professions students who were studying the topic for the first time. The feedback we have received over the years has affirmed that we met our goal, and that achievement has been a key element to the book’s success. Thus, in this fifth edition we have adhered to our original goal, maintaining all the proven elements of the last four editions.
Since 1992, much has been learned about kidney function at the cellular, molecular, and clinical level. Although this new information is exciting and provides new and greater insights into the function of the kidneys in health and disease, it can prove daunting to first-time students and in some cases may cause them to lose the forest for the trees. In an attempt to balance the needs of the first-time student with our desire to present some of the latest advances in the field of renal physiology, we have updated the highlighted text boxes, titled “At the Cellular Level” and “In the Clinic,” to supplement the main text for students who wish additional detail. The other features of the book, which include clinical material that illustrates important physiologic principles, multiple-choice questions, self-study problems, and integrated case studies, have been retained and updated. To achieve our goal of keeping the book concise, we have removed some old material as new material was added. We hope that all who use this book find that the changes have made it an improved learning tool and a valuable source of information.
To the instructor: This book is intended to provide students in the biomedical and health sciences with a basic understanding of the workings of the kidneys. We believe that it is better for the student at this stage to master a few central concepts and ideas rather than to assimilate a large array of facts. Consequently, this book is designed to teach the important aspects and fundamental concepts of normal renal function. We have emphasized clarity and conciseness in presenting the material. To accomplish this goal, we have been selective in the material included. The broader field of nephrology, with its current and future frontiers, is better learned at a later time and only after the “big picture” has been well established. For clarity and simplicity, we have made statements as assertions of fact even though we recognize that not all aspects of a particular problem have been resolved.
To the student: As an aid to learning this material, each chapter includes a list of objectives that reflect the fundamental concepts to be mastered. At the end of each chapter, we have provided a summary and a list of k

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