Rheumatology E-Book

Marc C. Hochberg

Description

Stay current in the ever-changing discipline of rheumatology with clear, reliable guidance from Hochberg’s Rheumatology, one of the most respected and trusted sources in the field. Designed to meet the needs of the practicing clinician, this medical reference book provides extensive, authoritative coverage of rheumatic diseases from basic scientific principles to practical points of clinical management in a lucid, logical, user-friendly manner.

• Track disease progression and treat patients more effectively with the information on genetic findings, imaging outcomes, cell and biologic therapies, rheumatoid arthritis, and SLE.
• Incorporate recent findings about pathogenesis of disease; imaging outcomes for specific diseases like RA, osteoarthritis, and spondyloarthropathies; cell and biologic therapies; and other timely topics.

• Remain up to date on the latest information in rheumatology through 13 brand-new chapters covering biomedical and translation science, disease and outcome assessment, new imaging modalities, early emerging disease, clinical therapeutics, patient management, and rehabilitation.
• Take advantage of expanded coverage of small molecule treatment, biologics, biomarkers, epigenetics, biosimilars, and cell-based therapies.
• Focus on the core knowledge needed for successful results with each chapter co-authored by an internationally-renowned specialist in the field.
• Easily find the information you need thanks to a consistent, user-friendly format with templated content and large-scale images.

Informations

• Publié par: Mosby Ltd.
• Date de parution: 24 juin 2014
• Nombre de lectures: 1
• EAN13: 9780702063039
• Langue: English
• Poids de l'ouvrage: 15 Mo

Extrait

Rheumatology
Sixth Edition
Marc C. Hochberg, MD, MPH, MACP
Professor of Medicine and Epidemiology and Public Health; Head, Division of Rheumatology and Clinical Immunology, University of Maryland School of Medicine, Baltimore, Maryland
Acting Director, Gerontology Research Education and Clinical Center, Veterans Affairs Maryland Health Care System, Baltimore, Maryland
Alan J. Silman, MD, MSC, FRCP, FMEDSCI
Medical Director, Arthritis Research UK, Chesterfield, United Kingdom
Professor, Rheumatic Diseases Epidemiology, University of Manchester, Manchester, United Kingdom
Josef S. Smolen, MD, FRCP
Professor of Medicine; Chairman, Department of Medicine III, Division of Rheumatology, Medical University of Vienna, Vienna, Austria
Chairman, Second Department of Medicine, Center for Rheumatic Diseases, Hietzing Hospital, Vienna, Austria
Michael E. Weinblatt, MD
John R. and Eileen K. Riedman Professor of Medicine, Harvard Medical School, Boston, Massachusetts
R. Bruce and Joan M. Mickey Distinguished Chair in Rheumatology, Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Boston, Massachusetts
Michael H. Weisman, MD
Cedars-Sinai Chair in Rheumatology; Director, Division of Rheumatology; Professor of Medicine, Cedars-Sinai Medical Center, Los Angeles, California
Distinguished Professor of Medicine, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, California
Table of Contents
Cover image
Title page
Copyright
Dedication
Contributors
Preface
Acknowledgments
Volume 1
Section 1 The Scientific Basis of Rheumatic Disease
1 Epidemiologic concepts and classification of rheumatic and musculoskeletal conditions
Introduction
Descriptive epidemiology-how many people have the disease?
Analytic epidemiology-who is susceptible to the disease?
Where does the disease occur?
When does the disease occur?
Why does the disease occur?
Clinical epidemiology-what happens to people with the disease?
References
2 Principles of clinical outcome assessment
Introduction
Clinical outcome assessment: a conceptual framework
Fundamental principles of clinical outcome assessment
Statistical issues
Outcome assessment measures for musculoskeletal disorders
Multidimensional health status instruments
Assessment of adverse reactions
Measurement in clinical trials
Outcome measurement in routine clinical practice
References
3 Principles of health economics and application to rheumatic disorders
Introduction
Concepts of health economic analysis
Economic applications in rheumatic diseases
Conclusion
References
4 The synovium
Definitions
Embryology
Structure
Cell origins and recruitment
Function
Synovium as a target for immunologic disease
References
5 Articular cartilage
Overall tissue organization
Aggrecan
Collagen fibrillar networks
Molecules interacting at the cell surface and modulating chondrocyte behavior
Other molecular functions
Fragments of matrix proteins released during cartilage breakdown as molecular indicators of disease
References
6 Bone structure and function
Introduction
Organization of bone
Composition of bone
Bone cells
Growth, modeling, remodeling, and repair
References
7 Tendons and ligaments
Introduction
Acute tendon and ligament injuries
Ligament injury and repair
Chronic tendon pathology
Etiology of chronic tendinopathy
Histopathologic findings
Treatment of tendon and ligament pathology
Conclusion
References
8 Connective tissue responses to mechanical stress
Mechanosensitive connective tissue cells
Mechanocoupling
Mechanotransduction
Mechanical stimulation-activated signaling
Conclusion
References
9 Biomechanics of peripheral joints
Introduction
Biomechanics of whole joints
Biomechanics of tissues
References
10 Biomechanics of the spine
Introduction
Forces acting on the spine
Mechanical function of the spine
Injury
Biomechanics of disk degeneration
Spinal degenerative cascade
Osteoporotic vertebral deformity
References
11 Principles of genetic epidemiology
Introduction
Complex rheumatic diseases
Rationale for investigating the genetic basis of rheumatic diseases
Approaches for identifying disease genes
Successful examples of candidate association studies
Whole-genome association studies of rheumatologic conditions
New horizons
References
12 Principles and techniques in molecular biology
Introduction
The human genome sequence and biomedical research
Basic manipulation of dna: cloning vectors and cutting and pasting DNA using enzymes
Polymerase chain reaction
DNA sequencing
Gene transcription
Expression profiling
Regulation of gene expression and protein-DNA interactions
Analysis of gene function
Genetic manipulation of mice
Analysis of proteins
Proteomics
Molecular biology: the new pathology for the practicing rheumatologist?
References
13 Cytokines
Introduction
Interleukin-1 receptor family
Tumor necrosis factor receptor superfamily
Type I and II cytokine receptors-hematopoietin and interferon receptors
Interleukin-17 receptors
Transforming growth factor- receptor family cytokines
Receptor tyrosine kinases
Chemokines
Other cytokines
References
14 Signal transduction in immune cells
Introduction
Membrane-permeable ligands that bind intracellular receptors
Receptors with intrinsic enzymatic activity
Receptors that associate with enzymes
Innate recognition of pathogens
G protein-coupled receptors
Summary
References
15 Principles of adaptive immunity
Introduction
The adaptive immune system
B cells and humoral immunity
T cells and cell-mediated immunity
Autoimmunity and tolerance
Conclusion
References
16 Principles of innate immunity
Introduction
Sensing by innate immunity
Phylogenetic comparison of the recognition system
Critical functions of innate immunity
Molecular mechanism of sensor signaling
Sensors and diseases
Conclusion
Acknowledgments
References
17 Systems biology
Introduction
What is systems biology?
Example of systems biology in practice
Key technologies empowering systems biology
Case studies
Future of systems biology in rheumatology
Acknowledgments
References
18 Epigenetics in rheumatology
What is epigenetics?
The basic mechanisms
Epigenetics in disease
Epigenetics and MicroRNA
References
19 The microbiome in rheumatic diseases
Introduction
The microbiome
Mucosal barriers and host-immune interactions
Research methods for study of the human microbiome
The microbiome in animal models of inflammatory arthritis
The microbiome in human inflammatory arthritis
Conclusion
References
20 Tissue destruction and repair
Introduction
Proteolytic pathways of connective tissue breakdown
Extracellular proteolysis-neutral proteinases
Intracellular pathways-acid proteinases
Osteoclastic bone resorption
Model systems of cartilage breakdown
Metalloproteinase-deficient mice in models of disease
Therapeutic inhibition of proteinases
Repair of connective tissue matrix
Models of matrix repair
References
21 Principles of tissue engineering and cell- and gene-based therapy
Introduction
Tissue engineering
Autologous chondrocyte implantation
Mesenchymal stem cells
Gene transfer strategies
References
22 Osteoimmunology
Introduction
Current concepts in osteoimmunology
Osteoclasts as triggers of arthritic bone erosions
Molecular and cellular mechanisms of inflammatory bone erosion
Periarticular and systemic bone loss in rheumatic disease
Osteoimmunologic aspects of bone formation in rheumatic disease
Bone marrow as a niche for B-cell differentiation and autoantibody formation
Conclusion
References
23 Inflammation and its mediators
Introduction
The cells of inflammation
Inflammatory mediators
The nervous system in inflammation
References
24 Scientific basis of pain
Nociception and pain
The peripheral basis of pain
The central basis of pain
Conclusion
References
25 Effects of the neuroendocrine system on development and function of the immune system
Introduction
Neuroendocrine system
Vitamin D in chronic inflammatory autoimmune diseases
Circadian rhythms and the immune system
Conclusion
References
26 Interpreting the medical literature for the rheumatologist
Introduction
Levels of evidence
Randomized controlled trials or observational studies?
Critical appraisal i: issues pertaining to randomized controlled trials
Critical appraisal ii: issues pertaining to observational studies
Critical appraisal iii: issue