Transplantation Dermatology

Description

Patients undergoing solid organ and hematopoietic stem cell transplantation frequently develop skin diseases that can be challenging to themselves and their doctors.In the first part of this volume, prevalent epidemiological, clinical and histological skin problems of solid organ recipients are discussed. Pre- and posttransplant management as well as follow-up programs are presented focusing on European and Swiss guidelines. A special chapter is dedicated to immunosuppressive drugs considering current standards, and new and upcoming medication. The second part starts with a summary of historical aspects of hematopoietic stem cell transplantation, and proceeds with a description of skin manifestations of graft-versus-host disease and their therapy. Covered are early, late and very late periods after transplantation with a focus on recent consensus classification and treatment aspects of chronic graft-versus-host disease. The publication ends with a comprehensive review and practical guidance on photoprotection in transplant recipients.This book covers all the important dermatological aspects that should be considered in diagnosis and treatment of recipients of solid organ and hematopoietic stem cell transplants. It is intended as a guide for dermatologists, nephrologists, hemato-oncologists and all specialists involved in the field of transplantation.

Informations

• Publié par: S. Karger AG
• Date de parution: 29 février 2012
• Nombre de lectures: 0
• EAN13: 9783805598569
• Langue: English
• Poids de l'ouvrage: 2 Mo

Extrait

Transplantation Dermatology
Current Problems in Dermatology
Vol. 43
Series Editors
Peter Itin    Basel
Gregor Jemec    Roskilde
 
Transplantation Dermatology
Volume Editors
Peter Häusermann Basel
Jürg Steiger Basel
Jakob Passweg Basel
41 figures, 39 in color, and 16 tables, 2012
Current Problems in Dermatology
_________________________
__________________________
Dr. Peter Häusermann Leitender Arzt Dermatologie Universitätsspital Basel Petersgraben4 CH-4031 Basel Switzerland
Prof. Jürg Steiger Chefarzt Klinik für Transplantationsimmunologie und Nephrologie Universitätsspital Basel Petersgraben 4 CH-4031 Basel Switzerland
__________________________
Prof. Jakob Passweg Chefarzt Hämatologie Universitätsspital Basel Petersgraben 4 CH-4031 Basel Switzerland
Library of Congress Cataloging-in-Publication Data
Transplantation dermatology / volume editors, Peter Häusermann, Jürg Steiger, Jakob Passweg.
p.; cm. - (Current problems in dermatology, ISSN 1421-5721; v.43)
Includes bibliographical references and index.
ISBN 978-3-8055-9855-2 (hard cover: alk. paper) –– ISBN 978-3-8055-9856-9 (e-ISBN)
I. Häusermann, Peter. II. Steiger, Jürg. III. Passweg, Jakob. IV. Series: Current problems in dermatology; v. 43.1421-5721
[DNLM: 1. Skin Diseases-etiology. 2. Hematopoietic Stem Cell Transplantation-adverse effects. 3. Immunocompromised Host. 4. Immunosuppressive Agents-adverse effects. 5. Organ Transplantation-adverse effects. 6. Skin Diseases-pathology. 7. Sunscreening Agents-therapeutic use. W1 CU804L v.43 2012 /WR 140] 617.4’7701-dc23
2011053286
Bibliographic Indices. This publication is listed in bibliographic services, including MEDLINE/Pubmed.
Disclaimer. The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publisher and the editor(s). The appearance of advertisements in the book is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
Drug Dosage. The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any change in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
© Copyright 2012 by S. Karger AG, P.O. Box, CH-4009 Basel (Switzerland)
www.karger.com
Printed in Germany on acid-free and non-aging paper (ISO 9706) by Kraft Druck GmbH, Ettlingen
ISSN 1421-5721
e-ISSN 1662-2944
ISBN 978-3-8055-9855-2
e-ISBN 978-3-8055-9856-9
 
Contents
Preface
Häusermann, P. (Basel)
Dermatology in Organ Transplant Recipients
Organ Transplantation and Skin - Principles and Concepts
Hofbauer, G.F.L.; Freiberger, S.N.; Iotzova-Weiss, G.; Shafaeddin, B.; Dziunycz, P.J. (Zürich)
Skin Problems in Immunodeficient Patients
Itin, P.H.; Battegay, M. (Basel)
Critical Skin Cancer in Organ Transplant Recipients - A Dermatopathological View
Kempf, W. (Zürich); Mertz, K.D. (Zürich/Liestal); Kanitakis, J. (Lyon); Hofbauer, G.F.L. (Zürich)
Immunosuppressive Drugs in Organ Transplant Recipients - Rationale for Critical Selection
Stucker, F.; Marti, H.-P.; Hunger, R.E. (Bern)
Human Papillomavirus and Squamous Cell Cancer of the Skin-Epidermodysplasia Verruciformis-Associated Human Papillomavirus Revisited
Arnold, A.W. (Basel/Freiburg); Hofbauer, G.F.L (Zürich)
Pre- and Posttransplant Management of Solid Organ Transplant Recipients: Risk-Adjusted Follow-Up
Schreve, B.S. (Zürich); Anliker, M. (St. Gallen); Arnold, A.W. (Basel); Kempf W. (Zürich); Laffitte, E. (Genève); Lapointe, A.-K. (Lausanne); Mainetti, C. (Bellinzona); Pelloni, F. (Lugano); Oberholzer, P. (Bern); Serra, A. (Zürich); Streit, M. (Aarau); Hofbauer, G.F.L. (Zürich)
Future Trends in Organ Transplant Recipients - Important Issues for Dermatologists
Zecher, D.; Steiger, J. (Basel)
Dermatology in Hematopoietic Stem Cell Transplantation
History of Hematopoietic Stem Cell Transplantation: Evolution and Perspectives
Gratwohl, A. (Basel); Niederwieser, D. (Leipzig)
Acute and Chronic Skin Graft-versus-Host Disease - Pathophysiological Aspects
Socié, G.; Peffault de Latour, R.; Bouziz, J.D.; Rybojad, M. (Paris)
Cutaneous Graft-versus-Host Disease - Clinical Considerations and Management
Wu, P.A. (Boston, Mass.); Cowen, E.W. (Bethesda, Md.)
UV Treatment of Chronic Skin Graft-versus-Host Disease - Focus on UVA1 and Extracorporeal Photopheresis
Greinix, H.T.; Tanew, A.(Vienna)
Late Effects after Hematopoietic Stem Cell Transplantation - Critical Issues
Tichelli, A.; Rovó, A. (Basel); Socié, G. (Paris)
Drug Hypersensitivity Reactions during Hematopoietic Stem Cell Transplantation
Bircher, A.J.; Scherer Hofmeier, K. (Basel)
Future Trends in Hematopoietic Stem Cell Transplantation
Halter, J.; Passweg, J.; Häusermann, P. (Basel)
Photoprotection
Photoprotection in Transplant Recipients
Surber, C. (Basel); Pittelkow, M. (Rochester, Minn.); Lautenschlager, S. (Zürich)
Author Index
Subject Index
 
Preface
Transplantation Dermatology provides dermatologists and physicians of other specialities with a comprehensive overview of the most important skin-related issues in the field of solid organ and hematopoietic stem cell transplantation.
The first section summarizes all the important knowledge on solid organ transplantation and skin. The chapters first cover the main principles and concepts of solid organ recipients and end with the most important health-related expectations and future trends of treatment. In between, the related epidemiological, clinical and histological skin problems are discussed. Pre- and posttransplant management and follow-up programs focus on international as well as European and Swiss guidelines. Finally, important knowledge is summarized related to standard, new and upcoming immunosuppressive drugs.
The second section provides the dermatologist with all the relevant information on what is to be expected in recipients of hematopoietic stem cell transplantation. Hallmark historical aspects are summarized and most important information is given in the setting of early, late and very late periods after transplantation. Skin manifestations of graft-versus-host disease and their respective therapeutic options are explained, and the new consensus classification and treatment aspects of chronic graft-versus-host disease are highlighted.
In the final section, the authors give a comprehensive and easy to read review and practical guidance on all the relevant aspects of photoprotection.
We sincerely hope that this book will be of help and interest to all physicians involved in the diagnosis, management and overall care of patients after solid organ and hematopoietic stem cell transplantation. The importance of updated information in that field is underlined by the fact that the number of solid organ and hematopoietic stem cell transplantations is rising worldwide.
The editors would like to thank all the participating authors for their time and effort put into finalizing this project. Many thanks also go to Karger Publishers for their support and to the sponsors of this book.
Finally, I would like to dedicate this book to my dearest Katharina, Maxine, Renée and Niggi.
Peter Häusermann , Basel
Dermatology in Organ Transplant Recipients
Häusermann P, Steiger J, Passweg J (eds): Transplantation Dermatology. Curr Probl Dermatol. Basel, Karger, 2012, vol 43, pp 1-8
______________________
Organ Transplantation and Skin – Principles and Concepts
Günther F.L. Hofbauer Sandra N. Freiberger Guergana Iotzova-Weiss Bahar Shafaeddin Piotr J. Dziunycz
Dermatologische Klinik, Universitätsspital Zürich, Zürich, Switzerland
______________________
Abstract
Solid organ transplantation influences the biology of the skin profoundly. In the wake of transplantation, inflammatory, infectious and neoplastic disorders arise, often with atypical clinical presentation. Inflammatory disorders mainly relate to pathogen-driven conditions such as seborrheic dermatitis and pityrosporum folliculitis and to drug reactions. Infectious disorders are dominated by viral infections of human papilloma virus and by infections and reactivations of herpes family members. Neoplastic disorders are greatly increased with squamous cell carcinoma of the skin as most re