Yearbook of Pediatric Endocrinology 2010

Description

The body of knowledge in most medical specialties is rapidly expanding, making it virtually impossible to follow all advances in clinical and basic sciences that are relevant to a given field. This is particularly true in pediatric endocrinology, at the cross-road of pediatrics, endocrinology, development and genetics. Providing abstracts of articles that report the year’s breakthrough developments in the basic sciences and evidence-based new knowledge in clinical research and clinical practice that are relevant to the field, the Yearbook of Pediatric Endocrinology 2010 keeps busy clinicians and scientists, pediatric endocrinologists, and also pediatricians and endocrinologists informed on new advances. Twelve Associate Editors and their co-authors selected from several thousand papers those that brought the most meaningful new information, summarized them and provided comments to put them into perspective. The papers are classified into those that identify new genes involved in diseases, new hormones, concepts revised or re-centered, important observations for clinical practice, large-scale clinical trials, new mechanisms, new paradigms, important review articles, new fears and new hopes. Because the Yearbook is endorsed by the European Society for Paediatric Endocrinology (ESPE), its publication is linked to the annual meeting of the ESPE. The Yearbook of Pediatric Endocrinology 2010 covers the medical and scientific literature from June 2009 through May 2010.

Informations

• Publié par: S. Karger AG
• Date de parution: 13 septembre 2010
• Nombre de lectures: 0
• EAN13: 9783805596022
• Langue: English
• Poids de l'ouvrage: 1 Mo

Extrait

Yearbook of Pediatric Endocrinology 2010
Yearbook of
Pediatric Endocrinology 2010
Endorsed by the European Society for Paediatric Endocrinology
Editors
Jean-Claude Carel
Ze’ev Hochberg
Associate Editors
Gary Butler
Evangelia Charmandari
Francesco Chiarelli
Stefano Cianfarani
Mehul Dattani
Nicolas De Roux
Ken Ong
Orit Pinhas-Hamiel
Michel Polak
Lars Sävendahl
Olle Söder
Martin Wabitsch
Sponsored by a grant from Pfizer Endocrine Care
Disclaimer. The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publisher and the editor(s). The appearance of advertisements in the book is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
Drug Dosage. The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any change in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
© Copyright 2010 by S. Karger AG, P.O. Box, CH-4009 Basel (Switzerland)
www.karger.com
Printed in Switzerland on acid-free and non-aging paper (ISO 9706) by Reinhardt Druck, Basel
ISBN 978-3-8055-9601-5
ISSN 1662-3391
Editors
Jean-Claude Carel
Pediatric Endocrinology and Diabetology, and INSERM U690, University Paris 7
Denis Diderot, Hôpital Robert Debré, 48, boulevard Sérurier, FR-75935 Paris cedex 19, France
Tel. [phone]; Fax [phone]; E-Mail [e-mail]
Ze‘ev Hochberg
Meyer Children’s Hospital, Rambam Medical Center, Faculty of Medicine
Technion-Israel Institute of Technology, POB 9602
IL-31096 Haifa, Israel
Fax [phone]; E-Mail [e-mail]
Associate Editors
Gary E. Butler
Department of Paediatrics and Adolescents
University College London Hospital, 250 Euston Road, London NW1 2PQ, UK
Tel. [phone] ext. 5240, E-Mail [e-mail]
Evangelia Charmandari
Division of Endocrinology and Metabolism, Clinical Research Center
Biomedical Research Foundation of the Academy of Athens
4 Soranou tou Efessiou Street, GR-11527 Athens, Greece
Tel. [phone], Fax [phone], E-Mail [e-mail]
Francesco Chiarelli
Department of Pediatrics, University of Chieti, Via dei Vestini, 5
IT-66013 Chieti, Italy
Tel. [phone], Fax [phone], E-Mail [e-mail]
Stefano Cianfarani
Department of Public Health and Cell Biology
Tor Vergata University
Room E178, Via Montpellier 1, IT-00133-Rome, Italy
Tel. [phone], Fax [phone], E-Mail [e-mail]
Mehul T. Dattani
Developmental Endocrine Research Group
Clinical and Molecular Genetics Unit, Institute for Child Health
University College London
London, WC1N 1EH, UK
Tel. [phone], Fax [phone], E-Mail [e-mail]
Nicolas De Roux
INSERM U 690, Laboratoire d’Hormonologie, AP-HP
Hôpital Robert Debré, 48 Boulevard Sérurier
FR-75019 Paris, France
Tel. [phone], Fax [phone], E-Mail [e-mail]
Ken Ong
Medical Research Council Epidemiology Unit
Institute of Metabolic Science, Addenbrooke’s Hospital, Box 285
Cambridge CB2 0QQ, UK
Tel. [phone]; Fax [phone]; E-Mail [e-mail]
Orit Pinhas-Hamiel
Pediatric Endocrine and Diabetes Unit, Safra Children’s Hospital
Sheba Medical Center Ramat-Gan
IL-52621 Ramat-Gan, Israel
Tel. [phone], Fax [phone], E-Mail [e-mail]
Michel Polak
Service d’endocrinologie pédiatrique
INSERM EMI 0363, Hôpital Necker-Enfants Malades
149, rue de Sèvres, FR- 75015 Paris
Tel. [phone], Fax [phone], E-Mail [e-mail]
Lars Sävendahl
Pediatric Endocrinology Unit; Q2:08
Department of Woman and Child Health
Karolinska Institutet and University Hospital, Solna
SE-171 76 Stockholm, Sweden
Tel. [phone]; Fax [phone]; E-Mail [e-mail]
Olle Söder
Pediatric Endocrinology Unit, Q2:08
Department of Woman and Child Health
Karolinska Institutet and University Hospital, Solna
SE-171 76 Stockholm, Sweden
Tel. [phone], Fax [phone], E-Mail [e-mail]
Martin Wabitsch
Pediatric Endocrinology, Diabetes and Obesity Unit, Department of Pediatrics and Adolescent Medicine
University of Ulm, Eythstrasse 24
DE-89075 Ulm, Germany
Tel. [phone]; E-Mail [e-mail]
Table of Contents
Preface
Ze’ev Hochberg and Jean-Claude Carel
Neuroendocrinology
Carine Villanueva, Lukas Huihjbregts and Nicolas de Roux
Pituitary
Evelien F. Gevers and Mehul T. Dattani
Thyroid
Michel Polak, Gabor Szinnai, Aurore Carré and Mireille Castanet
Growth and Growth Factors
Stefano Cianfarani
Bone, Growth Plate and Mineral Metabolism
Terhi Heino, Dov Tiosano, Aneta Gawlik and Lars Sävendahl
Reproductive Endocrinology
Olle Söder and Lena Sahlin
Adrenals
Erica L.T. van den Akker and Evangelia Charmandari
Type 1 Diabetes: Clinical and Experimental
Francesco Chiarelli and M. Loredana Marcovecchio
Obesity and Weight Regulation
Martin Wabitsch, Daniel Tews, Michaela Keuper, Carsten Posovszky,
Christian Denzer, Anja Moss, Julia von Schnurbein and
Pamela Fischer-Posovszky
Type 2 Diabetes Mellitus, Metabolic Syndrome, Lipids
Orit Pinhas-Hamiel
Population Genetics and Pharmacogenetics
Ken K. Ong and Cathy Elks
Evidence-Based Medicine in Pediatric Endocrinology
Gary E. Butler
Editor’s Choice
Jean-Claude Carel and Ze’ev Hochberg
Science and Medicine
Ze’ev Hochberg and Jean-Claude Carel
Author Index
Subject Index
Preface
The approach and fusion of many basic, translational and clinical aspects of medicine make it increasingly difficult to define the limits of subjects to be included in a short presentation of pediatric endocrine highlights of the year. The enormous advances of modern medical science, as summarized in the 2010 Yearbook of Pediatric Endocrinology , are based on new knowledge and concepts in the diverse fields of genetics and genomics, innate immunology, molecular biology, systems biology, population genetics, proteomics and metabolomics, evolutionary biology - all of which require attention in our consideration of the nature and mechanism of disease processes; modern diagnosis and therapy depend on such consideration.
The task of presenting recent advances in a concise but comprehensive form seems no less important as the difficulty increases. In fulfilling this task, we have kept in view the original purpose of a compact and condensed volume. As such, the Yearbook has been, and continues to be, useful to basic scientists who wish to understand the clinical issues of modern pediatric endocrinology, to clinical scientists who wish to base their research on the most recent developments in the field, and to clinicians who must maintain familiarity with the foundation sciences of medical practice as they evolve.
In the Yearbook Preface, we annually recognize the anniversary of a major scientific breakthrough. 100 years ago, in 1910, Artur Biedl, Professor of General and Experimental Pathology at the German University in Prague, published the first textbook on endocrinology that was promptly translated into English: Internal Secretion: The Basic Physiology and Significance for Pathology , Urban & Schwarzenberg, Berlin. The book listed more than 8,500 references, only about 1% of which had been published prior to 1889. This averages more than 400 papers a year during the first 20 years of the field [Wilson, 2005].
The fiction author James Morrow, who is best known for his Godhead Trilogy novels, centering on the literal bodily death of the Godhead of Judeo-Christian theology, wrote: Everybody thinks he’s being oh-so-deep when he says science doesn’t have all the answers.... Science does have all the answers.... The problem is that we don’t have all the science. This Yearbook attempts to provide the 2009-10 chapter of the pediatric endocrine science.
We are grateful to our twelve Associate Editors and their coauthors, who have done an enormous work to discern this year’s advances a