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Allergy and Allergic Diseases

2184 pages
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This two volume book is an outstanding reference source on all aspects of allergy and allergic diseases. Covering virtually every allergic condition, from the immunological and molecular basis of the allergic response to future trends in allergic disease prevention, this new international editorial team (A.B.Kay, Jean Bousquet, Pat Holt and Allen Kaplan) have completely revised and updated the text, from both a scientific and clinical perspective. References will continue to be added to the text until it goes to press making this the most up-to-date book available in the field.

This second edition consists of more than 1,800 pages contained within 98 chapters.

The price includes a fully searchable companion CD ROM with the complete text and over 300 images from the book in full colour.

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List of Contributors, ix
Foreword, xvii
Preface, xviii
V O L U M E 1 The Scientific Basis of Allergy
Part 1Immunology of the Allergic Response
1 Allergy and Hypersensitivity: History and Concepts, 3 A. Barry Kay 2 Development of Allergy and Atopy, 23 Catherine Thornton and Patrick G. Holt 3 T Cells and Cytokines in Asthma and Allergic Inflammation, 48 Chris Corrigan 4 Regulatory T Cells and Other Tolerogenic Mechanisms in Allergy and Asthma, 83 Catherine Hawrylowicz and Cezmi A. Akdis 5 IgE and IgE Receptors, 103 Brian J. Sutton, Andrew J. Beavil, Rebecca L. Beavil and James Hunt 6 Immunoglobulin Gene Organization and Expression and Regulation of IgE, 119 Hannah J. Gould and David J. Fear 7 Environmental Factors in IgE Production, 141 Anne Tsicopoulos, Catherine Duez and Andrew Saxon 8 Antigen-presenting Dendritic Cells and Macrophages, 166 Bart N. Lambrecht and Hamida Hammad 9 Innate Immunity in Allergic Disease, 187 Ian Sabroe 10 Signal Transduction in Allergic and Inflammatory Cells, 203 Rafeul Alam
Part 2Inflammatory Cells and Mediators
11 Mast Cells: Biological Properties and Role in Health and Allergic Diseases, 217 Peter Bradding and Glenn Cruse 12 Eosinophils: Biological Properties and Role in Health and Disease, 258 Simon P. Hogan, Helene F. Rosenberg, Redwan Moqbel, Simon Phipps, Paul S. Foster, Paige Lacy, A. Barry Kay and Marc E. Rothenberg 13 Neutrophils: Biological Properties and Role in Health and Allergic Diseases, 295 Alison M. Condliffe, Andrew S. Cowburn and Edwin R. Chilvers 14 Basophils: Biological Properties and Role in Allergic Diseases, 320 Gianni Marone, Giuseppe Spadaro and Arturo Genovese
15 Leukocyte Adhesion in Allergic Inflammation, 337 Michelle J. Muessel and Andrew J. Wardlaw 16 Airway Epithelium, 366 Pedro C. Avila and Robert P. Schleimer 17 Airway Vascularity in Asthma, 398 John W. Wilson 18 Fibroblasts and the Extracellular Matrix, 412 Lynne A. Murray, William G. Glass, Anuk M. Das and Geoffrey J. Laurent 19 Immune Complexes and Complement: Their Role in Host Defense and in Disease, 436 Michael M. Frank and C. Garren Hester 20 Bradykinin Pathways and Allergic Disease, 451 Allen P. Kaplan 21 Chemokines, 471 James E. Pease and Timothy J. Williams
22 Neurotrophins, 494 Wolfgang A. Nockher, Sanchaita Sonar and Harald Renz
23 Neuropeptides, 511 David A. Groneberg and Axel Fischer
24 Late-phase Allergic Reactions in Humans, 524 Yee-Ean Ong and A. Barry Kay
Part 3Pharmacology
25 Antihistamines, 551 F. Estelle R. Simons and Keith J. Simons
26 Lipid Mediators: Leukotrienes, Prostanoids, Lipoxins, and Platelet-activating Factor, 566 Sophie P. Farooque, Jonathan P. Arm and Tak H. Lee
27 Theophylline and Isoenzyme-selective Phosphodiesterase Inhibitors, 634 Mark A. Giembycz
28 Adrenergic Agonists and Antagonists, 668 Tony R. Bai
29 Cholinergic Antagonists, 683 Nicholas J. Gross
30 Antileukotriene Agents, 694 Graeme P. Currie and Brian J. Lipworth
31 Glucocorticosteroids, 715 Peter J. Barnes
32 Immunomodulating Drugs, 732 Iain A.M. MacPhee
Part 4Physiology
33 Physiologic Aspects of Asthma, 749 Philip W. Ind and Neil B. Pride
34 Aerosol Delivery Systems, 768 Thomas G. O’Riordan and Gerald C. Smaldone 35 Bronchial Hyperresponsiveness, 783 Guy F. Joos 36 Exercise-induced Bronchoconstriction: Animal Models, 794 Arthur N. Freed and Sandra D. Anderson 37 Exercise-induced Bronchoconstriction: Human Models, 808 Arthur N. Freed and Sandra D. Anderson
38 Sensory and Autonomic Nervous System in Asthma and Rhinitis, 823 Bradley J. Undem and Kevin Kwong 39 Mucus and Mucociliary Clearance in Asthma and Allergic Rhinitis, 840 Duncan F. Rogers 40 Biology of Vascular Permeability, 857 Peter Clark
41 Airway Smooth Muscle, 874 Stuart J. Hirst
Part 5Allergens
42 Biochemistry of Allergens and Recombinant Allergens, 895 Rudolf Valenta 43 Host Responses to Allergens, 913 Wayne R. Thomas and Belinda J. Hales 44 Allergen Extracts and Standardization, 928 Ronald van Ree 45 Grass, Tree, and Weed Pollen, 942 Jean Emberlin 46 Fungi as Allergens, 963 Cathryn C. Hassett, W. Elliott Horner, Estelle Levetin, Laurianne G. Wild, W. Edward Davis, Samuel B. Lehrer and John Lacey 47 Dust Mites and Asthma, 984 Thomas A.E. Platts-Mills and Judith A. Woodfolk 48 Animal Allergens, 997 Adnan Custovic and Angela Simpson
49 Airborne Allergens and Irritants in the Workplace, 1017 Xaver Baur
50 Allergens from Stinging Insects: Ants, Bees, and Vespids, 1123 Te Piao King and Rafael I. Monsalve
51 Cockroach Allergens, Environmental Exposure, and Asthma, 1131 Martin D. Chapman and Anna Pomés
52 Food Allergens, 1146 Ricki M. Helm and A. Wesley Burks
53 Latex Allergy, 1164 Robyn E. O’Hehir, Michael F. Sutherland, Alexander C. Drew and Jennifer M. Rolland
Part 6Animal Models of Asthma
54 Primate Models of Allergic Asthma, 1187 Charles G. Plopper, Suzette M. Smiley-Jewell, Lisa A. Miller, Michelle V. Fanucchi, Michael J. Evans, Alan R. Buckpitt, Mark V. Avdalovic, Laurel J. Gershwin, Jesse P. Joad, Radhika Kajekar, Shawnessy D. Larson, Kent E. Pinkerton, Laura S. Van Winkle, Edward S. Schelegle, Emily M. Pieczarka, Reen Wu and Dallas M. Hyde
55 Airway Remodeling in Small Animal Models, 1202 Clare M. Lloyd
56 Are Animal Models of Asthma Useful?, 1214 Reinhard Pabst
V O L U M E 2 Allergic Diseases: Etiology, Diagnosis and Treatment
Part 7Etiology and Pathology
57 Genetics of Asthma and Atopic Dermatitis, 1225 Saffron A.G. Willis-Owen, Miriam F. Moffatt and William O.C. Cookson 58 Epidemiology of Asthma, Atopy, and Atopic Disease, 1239 Debbie L. Jarvis, Seif O. Shaheen and Peter Burney 59 The Allergy March, 1259 Ulrich Wahn
60 Outdoor Air Pollution and Allergic Airway Disease, 1266 Gennaro D’Amato 61 Indoor Air Pollution, 1279 Paul Harrison, Rebecca Slack and Sanjeev Bagga 62 Molecular Immunopathology of Allergic Disease, 1290 Susan Foley and Qutayba Hamid
Part 8Diagnosis of Allergic Disease
63 Principles and Practice of Diagnosis and Treatment of Allergic Disease, 1321 Anthony J. Frew and A. Barry Kay 64 Skin Testing in Diagnosis and Management of Respiratory Allergic Diseases, 1335 Pascal Demoly, Anaïs Pipet and Jean Bousquet 65 Allergy Testing in the Laboratory, 1346 Steven O. Stapel and Jörg Kleine-Tebbe 66 Measurement of Markers of Inflammation in Induced Sputum and Exhaled Air, 1368 Ian D. Pavord and Dominick E. Shaw
Part 9Allergic Rhinoconjunctivitis and Immunotherapy
67 Definition and Classification of Allergic Rhinitis and Upper Airways Diseases, 1383 Wytske Fokkens and Jean Bousquet 68 Pathophysiology of Allergic Rhinitis, 1402 Peter H. Howarth
69 Management and Treatment of Allergic Rhinitis, 1430 Jean Bousquet and Michael A. Kaliner
70 Nasal Polyps and Rhinosinusitis, 1454 Wouter Huvenne, Paul Van Cauwenberge and Claus Bachert
71 Ocular Allergy, 1482 Avinash Gurbaxani, Virginia L. Calder and Susan Lightman
72 Mechanisms in Allergen Injection Immunotherapy, 1510 Stephen J. Till and Stephen R. Durham
73 Allergen Injection Immunotherapy: Indications and Practice, 1522 Hans-Jørgen Malling
74 Sublingual Immunotherapy, 1543 G. Walter Canonica and Giovanni Passalacqua
75 Novel Approaches to Allergen Immunotherapy, 1555 Mark Larché
Part 10Asthma and its Treatment
76 Definition, Clinical Features, Investigations, and Differential Diagnosis of Asthma, 1567 Piero Maestrelli, Gaetano Caramori, Francesca Franco and Leonardo M. Fabbri
77 Asthma in Infancy and Childhood, 1591 John O. Warner
78 Pathogenesis of Asthma, 1608 Stephen T. Holgate
79 Pathology of Asthma, 1632 Peter K. Jeffery, A. Barry Kay and Qutayba Hamid 80 Management of Chronic Asthma, 1650 Peter J. Barnes 81 Anti-IgE in Persistent Severe Allergic Asthma, 1661 Marc Humbert, Stephen T. Holgate, Howard Fox and Jean Bousquet 82 Occupational Asthma, 1687 Paul Cullinan and Anthony J. Newman Taylor 83 New Drugs for the Treatment of Allergy and Asthma, 1712 Trevor T. Hansel, Ed Erin, Onn Min Kon and Peter J. Barnes
Part 11Eosinophil-associated Disease and Hypersensitivity Pneumonitis
84 Allergic Bronchopulmonary Aspergillosis, 1743 André-Bernard Tonnel, Stéphanie Pouwels-Frys and Isabelle Tillie-Leblond
85 Extrinsic Allergic Alveolitis/Hypersensitivity Pneumonitis, 1757 Michael C. Zacharisen and Jordan N. Fink
86 Pulmonary Eosinophilia, 1779 Jean-François Cordier and Vincent Cottin
87 Hypereosinophilic Syndromes, 1802 Hans-Uwe Simon
Part 12Allergy and the Skin
88 Atopic Dermatitis, 1813 Julia D. Proelss and Thomas Bieber
89 Contact Dermatitis, 1831 David I. Orton and Carolyn M. Willis
90 Urticaria and Angioedema, 1853 Allen P. Kaplan
91 Mastocytosis, 1878 Nataliya M. Kushnir-Sukhov, Dean D. Metcalfe and Jamie A. Robyn
Part 13Anaphylaxis and Allergy to Food and Drugs
92 Anaphylaxis, 1897 M. Rosario Caballero, Stephen J. Lane and Tak H. Lee
Companion CD-ROM
93 Food Allergy and Eosinophilic Gastroenteropathies, 1921 Scott H. Sicherer and Hugh A. Sampson
94 Drug Hypersensitivity, 1943 Werner J. Pichler
95 Hypersensitivity to Aspirin and other NSAIDs, 1966 Andrzej Szczeklik, Ewa NiLankowska-Mogilnicka and Marek Sanak
96 Insect Sting Allergy, 1980 Ulrich R. Müller
Part 14Prevention of Allergic Disease
97 Prevention of Allergic Disease, 1997 Susan L. Prescott and Bengt Björkstén
98 Prevalence of Atopic Disorders in a Developing World: Pitfalls and Opportunities, 2020 Maria Yazdanbakhsh, Taniawati Supali and Laura C. Rodrigues
A companion CD-ROM is included at the end of Volume 2 with: • the complete text of both volumes • a full text search function • over 300 of the text figures in full colour