Neonatal Hematology and Transfusion Medicine, An Issue of Clinics in Perinatology

Robert D. Christensen

Description

Recent advances in neonatal hematology, largely made by the authors of these chapters, are likely to generate wide spread and long-term improvements in outcomes, as well as reductions in costs of care. Publication of these advances in a single volume will facilitate dissemination of these techniques and practices. The advances include neuroprotection from erythropoietic stimulators, improved guidelines for platelet transfusions, evidence-based guidelines for FFP administration, improved diagnostic methods for genetic causes of severe neonatal jaundice, more accurate definitions of hematological perturbations in necrotizing enterocolitis and sepsis, and reduction in transfusions and in IVH rates by cord milking/delayed clamping.

Sujets

• Médecine
• Spécialités médicales
• Médecine Générale
• Hermatology
• Medical

Informations

• Publié par: Elsevier
• Date de parution: 12 novembre 2015
• Nombre de lectures: 0
• EAN13: 9780323402651
• Langue: English
• Poids de l'ouvrage: 5 Mo

Extrait

Clinics Review Articles CLINICS IN PERINATOLOGY
Neonatal Hematology and Transfusion Medicine

Robert D. Christensen, MD
Division of Neonatology and Division of Hematology/Oncology, University of Utah School of Medicine, Salt Lake City, UT, USA

Sandra E. Juul, MD, PhD
Division of Neonatology, University of Washington School of Medicine, Seattle, WA, USA

Antonio Del Vecchio, MD
Department of Women’s and Children’s Health, Neonatal Intensive Care Unit, Di Venere Hospital, Bari, Italy
ISSN  0095-5108 Volume 42 • Number 3 • September 2015
Elsevier
Table of Contents
Cover image
Title page
Copyright
Contributors
Consulting Editor
Editors
Authors
CME Accreditation Page
Target Audience
Learning Objectives
Accreditation
Disclosure of Conflicts of Interest
Unapproved/Off-Label Use Disclosure
To Enroll
Method of Participation
CME Inquiries/Special Needs
Forthcoming Issues
Forthcoming Issues
Recent Issues
Foreword: Neonatal Hematology and Transfusion Medicine: What We Can Learn from Pediatric Oncology Groups
Preface: The Expanding Evidence Base to Guide Neonatal Hematology and Transfusion Medicine Practice
Erythropoietin and Neonatal Neuroprotection
Key points
Infants at risk for neurodevelopmental impairment
Mechanisms of cell death
Erythropoietin as a neuroprotective agent for neonatal neuroprotection
Mechanism of action
Clinical trials of erythropoietin in neonatal populations
Summary of animal and human studies
Reference Intervals in Neonatal Hematology
Key points
Reference intervals
Methodology
Individual reference intervals
Neonatal Transfusion Medicine
Key points
Introduction
Summary
Hemolytic Disorders Causing Severe Neonatal Hyperbilirubinemia
Key points
Neonatal hemolytic disorders
Hemolytic disorders are frequently responsible for extreme neonatal hyperbilirubinemia
Identifying hemolytic causes of neonatal jaundice
Plasma Biomarkers of Oxidative Stress in Neonatal Brain Injury
Key points
Background
Plasma biomarkers of oxidative stress
Oxidative stress and neonatal brain injury
Summary
Umbilical Cord Blood—An Untapped Resource
Key points
Introduction
Delayed cord clamping or milking of the umbilical cord
Use of umbilical cord blood for initial laboratory testing
Summary
Darbepoetin Administration in Term and Preterm Neonates
Key points
Introduction
Clinical studies
Darbe dosing and pharmacokinetics
Preterm erythropoiesis-stimulating agent studies
Preterm neuroprotection
Term neuroprotection studies
Summary
Immunologic and Hematological Abnormalities in Necrotizing Enterocolitis
Key points
Introduction
Immunologic aspects of necrotizing enterocolitis
Hematological manifestations of necrotizing enterocolitis
Summary
Hematologic Aspects of Early and Late-Onset Sepsis in Preterm Infants
Key points
Introduction
Summary
Stem Cells
Key points
Introduction
Stem cell biology: a brief review
Stem cells for the treatment of postinsult injury in neonates
Utility of neonatal stem cell transplantation: general considerations
Summary
Platelet Transfusions in the Neonatal Intensive Care Unit
Key points
Introduction
Platelet transfusion practices
Primary hemostasis in the neonate
Relationship between severity of thrombocytopenia and bleeding risk
Do platelet transfusions decrease the incidence of bleeding?
Current recommendations
Future directions
Neonatal Platelet Function
Key points
Introduction
Platelet production in neonates
Platelet function in neonates
Disorders of neonatal platelet function
Evaluation of platelet function in neonates
Fresh Frozen Plasma Administration in the Neonatal Intensive Care Unit
Key points
Introduction
Epidemiology of fresh frozen plasma use in the neonatal intensive care unit
Recommendations derived from clinical studies on the appropriate use of fresh frozen plasma in neonates
Effect of fresh frozen plasma dose on clotting times
Implications of hemostasis assessment in therapeutic decision-making for fresh frozen plasma administration
Strategies to improve compliance with fresh frozen plasma administration guidelines in the neonatal intensive care unit
Summary
Thrombosis in the Neonatal Intensive Care Unit
Key points
Introduction
Neonatal hemostasis
Types and locations of neonatal thromboses
Risk factors for neonatal thromboses including appropriate laboratory evaluation
Management of thrombosis
Summary
Index
Copyright
ELSEVIER
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CLINICS IN PERINATOLOGY Volume 42, Number 3
September 2015 ISSN 0095-5108, ISBN-13: 978-0-323-40264-4
Editor: Kerry Holland
Developmental Editor: Casey Jackson
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Contributors

Consulting Editor
LUCKY JAIN, MD, MBA
Richard W. Blumberg Professor and Executive Vice Chairman, Department of Pediatrics, Emory University School of Medicine; Executive Medical Director, Children’s Healthcare of Atlanta Faculty Practices, Atlanta, Georgia

Editors
ROBERT D. CHRISTENSEN, MD
Divisions of Neonatology and Hematology/Oncology, Department of Pediatrics, University of Utah School of Medicine; Director of Neonatology Research, Women and Newborn's Program, Intermountain Healthcare Salt Lake City, Utah
SANDRA E. JUUL, MD, PhD
Chief, Division of Neonatology; Professor, Department of Pediatrics, University of Washington School of Medicine, Seattle, Washington
ANTONIO DEL VECCHIO, MD
Director, Department of Women and Childrens Health, Di Venere Hospita