Viral Infections in Asthma, An Issue of Immunology and Allergy Clinics

Hellermann Gary, Shyam Mohapatra

Description

This issue, Guest Edited by Drs. Shyam Mohapatra and Gary Hellermann, will include topics such as: Virus-induced airway injury and asthma inception; Pediatric infectious diseases and asthma; Rhinoviruses and inception or exacerbation of asthma; Respiratory syncytial virus infections in the adult asthmatic—role of viral subversion and host susceptibility in RSV infection; New rhinovirus clades and their significance in asthma exacerbation and airway remodeling; Metapneumovirus and asthma.

Sujets

• Medical
• Médecine
• Immunology

Informations

• Publié par: Saunders
• Date de parution: 28 novembre 2010
• Nombre de lectures: 0
• EAN13: 9781455700370
• Langue: English
• Poids de l'ouvrage: 2 Mo

Extrait

Immunology and Allergy Clinics of North America
Infectious Diseases and Asthma

Shyam Mohapatra
Divisions of Allergy and Immunology and Translational Medicine, Department of Internal Medicine, University of South Florida College of Medicine, 12908 USF Health Drive, Tampa, FL 33612, USA

Gary Hellermann
Divisions of Allergy and Immunology and Translational Medicine, Department of Internal Medicine, University of South Florida College of Medicine, 12908 USF Health Drive, Tampa, FL 33612, USA
ISSN  0889-8561 Volume 30 • Number 4 • November 2010
Elsevier
Table of Contents
Cover image
Title page
Contributors
Forthcoming Issues
Foreword
Preface
The Infectious March: The Complex Interaction Between Microbes and the Immune System in Asthma
Mechanisms of virus-induced immunopathology and asthma exacerbations
Viral Diversity in Asthma
Influenza viruses
Human coronaviruses
Parainfluenza viruses
Adenoviruses
Human bocaviruses
Polyomaviruses
Summary
Animal Models of Virus-induced Chronic Airway Disease
What might an ideal rodent model look like?
The Role of Respiratory Virus Infections in Childhood Asthma Inception
Virus infection and subsequent asthma development
Respiratory Syncytial Virus Infections in the Adult Asthmatic – Mechanisms of Host Susceptibility and Viral Subversion
RSV in adults and its impact on asthma exacerbations
New Human Rhinovirus Species and Their Significance in Asthma Exacerbation and Airway Remodeling
HRV history
HRV and asthma
Summary
Virus/Allergen Interactions and Exacerbations of Asthma
Role of viral infections in wheezing illnesses
Allergic sensitization as a risk factor for developing virus-induced wheeze and asthma
Allergy and virus-induced exacerbations of asthma
Response to experimental HRV infections in allergic asthmatics
Mechanisms of virus-allergen interactions
Does treatment of allergic asthma decrease exacerbations?
Summary
Bacterial Infections and Pediatric Asthma
Asthma phenotypes in children
Bacterial colonization in infancy and asthma in childhood
Antibiotics in early life as risk factors for asthma
Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis
Mycoplasma pneumoniae, Chlamydophila pneumoniae and Chlamydia species
Antibiotic treatment for acute and chronic asthma
Future perspectives
Summary
Effects of Atypical Infections with Mycoplasma and Chlamydia on Asthma
Mycoplasma pneumoniae and respiratory disease
Chlamydophila pneumoniae and respiratory disease
Diagnosis of atypical bacterial infections
Atypical bacterial infections and acute exacerbations
Atypical bacterial infections and the development of asthma
Atypical bacterial infections, chronic asthma, and severity of disease
Effects of antibiotics on atypical bacteria in asthma
Summary
Index
Contributors

Consulting editor
RAFEUL ALAM, MD, PhD
Veda and Chauncey Ritter Chair in Immunology, Professor, and Director, Division of Immunology and Allergy, National Jewish Health; and University of Colorado Health Sciences Center, Denver, Colorado

Guest Editors
SHYAM MOHAPATRA, PhD, FAAAI
Mabel and Ellsworth Simmons Professor of Allergy and Immunology, Divisions of Allergy and Immunology and Translational Medicine, Department of Internal Medicine, University of South Florida College of Medicine; James A. Haley Veterans Administration Hospital Medical Center, Tampa, Florida
GARY HELLERMANN, PhD
Senior Biological Scientist, Divisions of Allergy and Immunology and Translational Medicine, Department of Internal Medicine, University of South Florida College of Medicine, Tampa, Florida

Authors
PEDRO C. AVILA, MD
Associate Professor of Medicine, Division of Allergy-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois
SILVIO FAVORETO Jr, PhD, DDS
Research Associate Professor of Medicine, Biology Division, Cuesta College, San Luis Obispo, California
JAMES E. GERN, MD
Departments of Pediatrics and Medicine, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin
ALYSSA GREIMAN, BSc
Research Assistant, Division of Allergy-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois
GARY HELLERMANN, PhD
Senior Biological Scientist, Divisions of Allergy and Immunology and Translational Medicine, Department of Internal Medicine, University of South Florida College of Medicine, Tampa, Florida
DANIEL J. JACKSON, MD
Assistant Professor of Pediatrics, Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin
KIRSTEN M. KLOEPFER, MD
Departments of Pediatrics and Medicine, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin
MATTI KORPPI, MD, PhD
Professor, Pediatric Research Center, Tampere University and University Hospital, Tampere, Finland
MONICA KRAFT, MD
Professor of Medicine, Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, Duke University Medical Center, Durham, North Carolina
ROBERT F. LEMANSKE Jr, MD
Professor of Pediatrics and Medicine, Departments of Pediatrics and Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin
PETER MCERLEAN, PhD
Post-Doctoral Research Fellow, Division of Allergy-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois
GREGORY METZ, MD
Medical Instructor, Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, Duke University Medical Center, Durham, North Carolina
E. KATHRYN MILLER, MD, MPH
Assistant Professor, Pediatric, Pulmonary, Allergy and Immunology, Department of Medicine, Vanderbilt University Medical Center, Vanderbilt Children s Hospital, Nashville, Tennessee
SHYAM MOHAPATRA, PhD, FAAAI
Mabel and Ellsworth Simmons Professor of Allergy and Immunology, Divisions of Allergy and Immunology and Translational Medicine, Department of Internal Medicine, University of South Florida College of Medicine; James A. Haley Veterans Administration Hospital Medical Center, Tampa, Florida
R. STOKES PEEBLES Jr, MD
Associate Professor of Medicine, Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee
LOUIS A. ROSENTHAL, PhD
Scientist, Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin
BLAIR D. WESTERLY, MD
Resident in Internal Medicine, Department of Medicine, Vanderbilt University School of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee
TERIANNE WONG, BSc
Department of Molecular Medicine, University of South Florida College of Medicine, Tampa, Florida
Forthcoming Issues

Forthcoming Issues
February 2011
Stress and Immune-Based Diseases
Gailen D. Marshall, MD,
Guest Editor

May 2011
Rhinitis
Michael A. Kaliner, MD,
Guest Editor

August 2011
Allergen Immunotherapy
Linda Cox, MD, Guest Editor

Recent Issues
August 2010
Atopic Dermatitis
Mark Boguniewicz, MD, Guest Editor

May 2010
Hematopoietic Stem Cell Transplantation for Immunodeficiency: Part II
Chaim M. Roifman, MD, FRCPC, FCACB,
Guest Editor

February 2010
Hematopoietic Stem Cell Transplantation for Immunodeficiency: Part I
Chaim M. Roifman, MD, FRCPC, FCACB,
Guest Editor

RELATED INTEREST
Infectious Disease Clinics of North America (Volume 24, Issue 3, Pages 541–844, September 2010)
Emerging Respiratory Infections in the 21st Century
Alimuddin Zumla, FRCP, PhD(Lond), FRCPath, Wing-Wai Yew, MBBS,
FRCP (Edinb), FCCP, David S.C. Hui, MD(UNSW), FRACP, FRCP, Guest Editors
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Foreword
Infection and Asthma
Rafeul Alam, MD, PhD, Division of Allergy and Immunology, National Jewish Health and University of Colorado Denver Health Sciences Center, 1400 Jackson Street, Denver, CO 80206, USA. E-mail address: [e-mail]
Rafeul Alam, MD, PhD Consulting Editor

Infection has always been suspected to play a pivotal role in the pathogenesis and/or clinical course of asthma. Epidemiological studies have demonstrated an increased risk for atopy and asthma in children having recurrent infections or having infection with a specific microbe. Significant progress has been made in understanding the mechanism by which infection could augment an allergic immune response. The progress in the past was in part delayed by the dogma of Th1-Th2 antagonism. Allergic diseases represent a Th2 response, whereas infection typically elicits a Th1 response. Thus, it was conceptually difficult to reconcile a positive effect of infection on allergic inflammation. It should be stated that some publications had indicated a coexistence and even cooperation between Th1 and Th2 in asthma and atopic dermatitis. With the emergence of the concept of T-helper cell plasticity, it is now conceptually easier to imagine how infection could fuel an allergic response and tra