Fibrogenesis

Fibrogenesis

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Livres

Description

Fibrogenesis: Cellular and Molecular Basis is the first volume to provide a synopsis of the rapid progress that has been documented in fibrogenesis over last couple of years, which significantly enhanced our understanding of the pathomechanisms of fibrotic diseases. Knowledge on molecular and celluar basis of fibrotic diseases has provided opportunities to develop selective and effective gene-based therapeutic options.


The chapters in this book have been selected to provide comprehensive information on fibrogenesis, which is not limited to any specific organ. Individual chapters present mechanisms of fibrotic diseases involving lung, liver, kidney, heart, blood vessels, and more. The relevance and significance of inflammatory cytokines, chemokines, transcriptional factors, fibrogenic molecules, signaling cascade, and matrix remodeling in fibrogenesis are explained in depth, providing the reader with current and updated information.

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Informations

Publié par
Date de parution 06 mars 2007
Nombre de lectures 0
EAN13 9780387264769
Licence : Tous droits réservés
Langue English

Informations légales : prix de location à la page €. Cette information est donnée uniquement à titre indicatif conformément à la législation en vigueur.

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CONTENTS
Preface ................................................................................................ xiii
1. Tissue Scarring: Lessons from Wound Healing ...................................... 1 Mohammed S. Razzaque, Moussa ElHallak, Abdallah Azouz and Takashi Taguchi Wound Healing .................................................................................... 1 Fetal Wound Healing ............................................................................ 2 Tissue Scarring ...................................................................................... 3
2. Pathological Significance of Renal Expression of Proinflammatory Molecules ............................................................... 9 Takashi Wada, Mohammed S. Razzaque, Kouji Matsushima, Takashi Taguchi and Hitoshi Yokoyama Participants in Renal Inflammation ..................................................... 10 Major Mediators Involved in Renal Inflammation ............................... 11 Leukocyte Trafficking During Renal Inflammation ............................. 12 Chemokine Systems in the Kidney from Acute Injury to Renal Scarring: The Chemokine Cascade .................................... 12 The MCP1/CCL2TGFβAxis: A Common Regulatory Pathway of Chronic Renal Inflammation Resulting in Renal Scarring ............................................................................. 13 Molecular Basis of Inflammation in Various Renal Diseases ................ 14 Effectiveness of AntiChemokine/Cytokine Therapy and Its Possible Therapeutic Implications in Renal Diseases ............ 21
3. Oxidative Stress, Lipoproteins and Angiotensin II: The Unholy Triad in the Pathogenesis of Renal Fibrosis ..................... 27 Jan Galle, Thomas Quaschning and Stefan Seibold What Generates Oxidative Stress? ........................................................ 28 Biological Effects of Oxidative Stress ................................................... 28 Biological Effects of Oxidative Stress on Renal Fibrosis ....................... 28 Oxidative Stress and Changes in Cell Number and Cell Size ............... 30 Oxidative Stress and Proteinuria .......................................................... 30 Functional Consequence of Ang IIInduced Oxidative Stress in Renal Tissue ................................................................................ 31 Lipoproteins and Oxidative Stress ....................................................... 31 Functional Consequence of OxLDLInduced Oxidative Stress in Renal Tissue ................................................................................ 32
4. Involvement of NFκB in Renal Inflammation and Sclerosis ............... 38 Laurent Baud, Bruno Fouqueray, Agnes Bellocq, JeanPhilippe Haymannn and Julie Peltier Structure and Activation Pathways of NFκB ...................................... 38 Origin of NFκB Activation in Inflammatory Reaction ....................... 39 Monitoring of NFκB Activation ........................................................ 39 Role of NFκB in the Development of Renal Inflammation ................ 40
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Role of NFκB in the Development of Renal Fibrosis ......................... 40 NFκB Pathway As a Target for New AntiInflammatory and AntiFibrotic Treatments .......................................................... 41
LowDensity Lipoprotein and Glomerulosclerosis ................................ 45 Hyun Soon Lee Effects of Lipoprotein Abnormalities on the Glomerulus in Experimental Animals ................................................................. 46 Effects of LDL on Mesangial Cells ...................................................... 46 Effects of LDL on Glomerular Epithelial Cells .................................... 53
Molecular Developments in the Treatment of Renal Fibrosis ............... 61 Gavin J. Becker and Tim D. Hewitson Initiation ............................................................................................. 62 Fibrogenesis ......................................................................................... 63 Treatment Options Available and Developing ..................................... 66 Future Perspectives .............................................................................. 70
Myocardial Infarction and Cardiac Fibrogenesis .................................. 77 Shozo Kusachi and Yoshifumi Ninomiya Cellular and Molecular Events after Induction of the Myocardial Infarction ............................................................ 78 ECM Assembly ................................................................................... 81 ECM Components of Basement Membrane ........................................ 83 Proteoglycans ...................................................................................... 84 Matrix Proteins ................................................................................... 85 Mediators Affecting ECM Reformation .............................................. 87 Noninfarct Zone ................................................................................. 88 Intervention in Infarct Fibrogenesis ..................................................... 88
Cardiac Fibrosis and Aging .................................................................. 97 Serge Masson, Roberto Latini, Monica Salio and Fabio Fiordaliso AgeDependent Cardiac Fibrosis ......................................................... 97 Why Does Collagen Accumulate in the Aged Myocardium? ................ 99 Attenuation of Myocardial Stiffness During Aging ............................ 100 Diastolic Dysfunction and Failure ..................................................... 101
Matrix Remodeling and Atherosclerosis Effect of Age ........................ 104 Ladislas Robert The Genesis of the Disease ................................................................ 105 Impact of Cell Biology ...................................................................... 105 Other Etiological Factors ................................................................... 106 Role of Immune Factors .................................................................... 107 Role of Elastolysis .............................................................................. 107 Mechanism of Elastolysis ................................................................... 108
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Role of Lipids and of Calcium ........................................................... 110 Nature of Vascular Fibrosis ............................................................... 111 Role of Proteoglycans ........................................................................ 112 Role of Receptors .............................................................................. 112
Molecular and Cellular Aspects of Liver Fibrosis ................................ 118 Norifumi Kawada Stellate Cell As a Principal Player of Liver Fibrosis ............................ 118 Novel Therapeutic Strategy for Preventing Liver Fibrosis .................. 119
Recent Therapeutic Developments in Hepatic Fibrosis ...................... 122 Ichiro Shimizu Hepatocyte Injury and Oxidative Stress ............................................. 123 HSC Activation and Growth Factors ................................................. 125 Antifibrotic Therapy .......................................................................... 128
Reversibility of Liver Fibrosis: Role of Matrix Metalloproteinases ...... 143 Isao Okazaki, Tetsu Watanabe, Maki Niioka, Yoshihiko Sugioka and Yutaka Inagaki Reversibility of Human Liver Fibrosis ............................................... 144 Reversibility of Experimental Liver Fibrosis ....................................... 145 Biological Collagenase Activity in Recovery Stage of Liver Fibrosis ............................................................................. 146 Gene Expression of MMPs and TIMPs in Both Progressive Stage of Liver Fibrosis and Its Recovery ......................................... 148 Stem/Progenitor Cells Expressing MMP13 mRNA Appear in Recovery from Liver Cirrhosis ................................................... 152 Different Mechanisms in Recovery from Liver Fibrosis and That from Liver Cirrhosis ....................................................... 153
Can Manipulation of Apoptotic Cell Death Benefit Tissue Scarring? ................................................................................. 160 Wesam Ahmed, Mohammed S. Razzaque and Takashi Taguchi Apoptosis .......................................................................................... 161 Mechanisms of Apoptosis .................................................................. 161 The Intrinsic (Mitochondrial) Death Pathway ................................... 162 The Extrinsic (Receptor Mediated) Death Pathway ........................... 164 Cross Talk between Pathways ............................................................ 165 Bcl2 Proteins and Apoptosis ............................................................. 166 Signal Transduction (MAP Kinase) Pathways and Apoptosis ............. 166 PI3K/AKT Pathway and Apoptosis ................................................... 166 Other Modes of Cell Death ............................................................... 168 Paraptosis .......................................................................................... 170 Apoptosis and Tissue Scarring ........................................................... 170
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Pulmonary Fibrogenesis: The Role of Apoptosis and Its Clinical Potentials .................................................................. 178 Kazuyoshi Kuwano, Naoki Hagimata and Nobuyuki Hara Inflammatory Mediators .................................................................... 179 Growth Factors ................................................................................. 183 Epithelial Cell Apoptosis and Its Clinical Potentials .......................... 184 OxidantMediated Lung Injury in Pulmonary Fibrosis ...................... 187 Endothelium in Pulmonary Fibrosis .................................................. 188 EpithelialFibroblast Interaction in Pulmonary Fibrosis ..................... 189 Matrix Remodeling in Pulmonary Fibrosis ........................................ 189
SilicaInduced Inflammatory Mediators and Pulmonary Fibrosis ....... 199 Andrea K. Hubbard, Sarah Mowbray, Michael Thibodeau and Charles Giardina Silica and Silicosis .............................................................................. 199 SilicaInduced Lung Injury ................................................................ 199 SilicaInduced Mediators in Pulmonary Fibrosis ............................... 200
Index .................................................................................................. 211
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