Source: Moses et al., JAMA, Sept. 21, 2005 (based on PhRMA)
reinhard.angelmar@insead.edu
U.S. NME APPROVALS WITH PHASE IV COMMITMENTS
reinhard.angelmar@insead.edu
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HOW TO INCREASE R&D PRODUCTIVITY?
INCREASE OUTPUT Increase number of projects entering development Reduce attrition Increase in-licensing and acquisitions (no impact on industry output)
REDUCE COSTS Reduce attrition in Phases II & III Increase speed Reduce cost per patient
reinhard.angelmar@insead.edu
Nr. OF ACTIVE DEVELOPMENT PROGRAMS
1800
1600
1400
1200
1000
800
600 400 200
0
Phase I Phase II Phase III
March 2001 March 2002 March 2003 March 2004 March 2005