Applications of Surface Acoustic Waves (SAW) for Chemical and Biological Analysis by Kumudesh Sritharan The University of Augsburg Experimental Physics 1 Augsburg, Germany D-86159 1 Referees: Prof. Dr. Achim Wixforth (Thesis Advisor and Reviewer) Prof. Dr. Stefan W Schneider (Thesis Reviewer) Priv. Doz. Dr. Igor Goychuk Prof. Dr. Wolfgang Brutting thDate of Oral Exam: July 11 2008 2 Abstract The objective of the proposed thesis is to demonstrate the use of surface acoustic wave (SAW) for a chip based microfluidic system. We utilize this unique SAW chip as a nano-pump to move and mix small volumes of liquids in two dimensional and three dimensional channel geometries for both biological and chemical applications. For instance this technique enables us to analyze the complex interplay of the biochemical and physical properties of cells, proteins and chemicals in blood flow conditions. First of all the surface acoustic waves (SAW) are generated using a piezoelectric substrate where metal transducers are deposited to induce an oscillatory deformation on the chip surface. The SAW which is generated hits the solid liquid interface resulting in an acoustic streaming of the liquid.