Drug targeting delivery systems for treatment of Raf-1 induced lung tumors in mice [Elektronische Ressource] / vorgelegt von Samar Afify

Mohammed Moudjou

Sujets

• Gesundheit

Informations

• Publié par: julius-maximilians-universitat_wurzburg
• Publié le: 01 janvier 2007
• Nombre de lectures: 40
• Langue: Deutsch
• Poids de l'ouvrage: 2 Mo

Extrait

Drug targeting delivery systems for treatment
of Raf-1 induced lung tumors in mice






DISSERTATION

zur Erlangung
des naturwissenschaftlichen Doktorgrades
der Julius-Maximilians-Universität Würzburg





vorgelegt von
Samar Afify
aus Doha/Qatar



Würzburg 2007



















Eingereicht am:
bei der Fakultät für Chemie und Pharmazie


1. Gutachter: …………………………………….

2. Gutachter: …………………………………….

der Dissertation


1. Prüfer: …………………………………………

2. Prüfer: …………………………………………

3. Prüfer: …………………………………………

des Öffentlichen Promotionskolloquiums



Tag des Öffentlichen Promotionskolloquiums: ………………………….

Doktorurkunde ausgehändigt am: ………………………………………..



Die vorliegende Arbeit wurde auf Anregung und unter Anleitung von

Herrn Prof. Dr. Ulf Rapp

Institut für Medizinische Strahlenkunde und Zellforschung
der Julius-Maximilians-Universität Würzburg

und

Frau Prof. Dr. Petra Högger

am Lehrstuhl für Pharmazeutische Chemie
des Instituts für Pharmazie und Lebensmittelchemie
der Julius-Maximilians-Universität Würzburg angefertigt.























Meiner Familie



Teile der vorliegenden Dissertation wurden bereits an folgenden Stellen veröffentlicht

Original Publication
Afify S., Rapp UR., Högger P.: Validation of a liquid chromatography assay for the
quantification of the Raf kinase inhibitor BAY 43-9006 in small volumes of mouse
serum. J Chromatogr B Analyt Technol Biomed Life Sci 2004, 809(1):99-103.
Poster
Afify S., Rapp U., Högger P., Validation of HPLC method for the determination of
BAY 43-9006 in mouse serum, DPhG-Meeting, 2003, Würzburg.














ACKNOWLEDGEMENT
I wish to express my hearty appreciation and feeling of gratitude to Prof. Dr.
Ulf Rapp, for suggesting the subject, for his instructive supervision and
unlimited continual help that he kindly offered throughout the development of
this work.
I would like to express my sincere thanks to Prof. Dr. Petra Högger, for
giving me the chance to express myself in my research, for support and
helpful advices.
A very special thank to PD Dr. rer. nat. Rudolf Götz, our group leader,
Institut für Medizinische Strahlenkunde und Zellforschung, Würzburg
University, for his help.
Also I am profoundly grateful to Dr. Boris Kramer, Children Clinic,
Würzburg, for his great effort and help in the instillation of mice by the
intratracheal technique.
I would also like to express my thanks to Dr. Camarero Guadelupe, Institut
für Medizinische Strahlenkunde und Zellforschung, Würzburg University, for
her help in immunohistochemistry staining and for her advices.
I am particularly indebted and grateful to Dr. Manfred Ogris,
Pharmaceutical Biology-Biotechnology, Department of Pharmacy Ludwig-
Maximillans-University München, for supplying me with the cationic vectors.
My thanks are expressed to Prof. Dr. Georg Krohne, Department of Electron
Microscopes, for using his scanning electron microscope and to Dr. Ursula
Rdest, Microbiology Department, for performing centrifugation, Theodor-
Boveri-Institut, Faculty of Biology, Würzburg University.

Also I am deeply grateful to AR Dr. Sascha Zügner, Department of
Pharmaceutical Technology, Julius-Maximillians University, Würzburg, for
employing the coulter counter.
Very special thank to Roswitha Skrabala for excellent technical assistance by
HPLC analysis and my thanks are expressed to Angelika Schäfer for her
support and help during my research, Department of Pharmaceutical
Chemistry, Institute of Pharmacy and Food Chemistry, Julius-Maximillians
University, Würzburg.
I would like also to thank Doris, Tamara, Maureen, Alla and Nikolaj for their
wonderful technical assistance and also to Hilde for her help for supplying
me with mice. Special thanks for Tamara for her help in understanding mouse
language and culture, Institut für Medizinische Strahlenkunde und
Zellforschung, Würzburg University.
Also I am deeply grateful to all my colleagues at Institute of Pharmacy and
Food Chemistry, Julius-Maximillians University, Würzburg, for their
understanding sincere cooperation and encouragement which enable this
work to be completed.
It is difficult to express in few sentences the gratitude for my family, for their
love and support. The greatest acknowledgement I reserve for my husband
Mohamad, supporting me every time either mentally or in reality, to whom I
dedicate this dissertation.