Endothelial catabolism of extracellular adenosine during hypoxia [Elektronische Ressource] : role of surface adenosine deaminase and CD26 / vorgelegt von Simone Ulrike Knapp
Aus der Universitätsklinik für Anästhesiologie und Intensivmedizin Tübingen Ärztlicher Direktor: Professor Dr. K. Unertl Endothelial Catabolism of Extracellular Adenosine during Hypoxia: Role of Surface Adenosine Deaminase and CD26 Inaugural-Dissertation zur Erlangung des Doktorgrades der Medizin der Medizinischen Fakultät der Eberhard-Karls-Universität zu Tübingen vorgelegt von Simone Ulrike Knapp aus Heilbronn 2008 Dekan: Professor Dr. I. B. Autenrieth 1. Berichterstatter: Professor Dr. H. Eltzschig 2. Berichterstatter: Privatdozent Dr. V. Kempf List of contents Abbreviations ...................................................................................................... 7 1 Introduction ...... 9 1.1 Transendothelial migration of polymorphonuclear leukocytes ..................... 9 1.2 Structural and functional elements of the vascular barrier ......................... 10 1.3 Vascular barrier during inflammation ................................ 12 1.4 Increased adenosine production during hypoxia ....................................... 19 1.5 Role of adenosine deaminase in vascular inflammation during hypoxia .... 20 1.6 Aims of the study ...................................................... 22 2 Materials and Methods................................................... 23 2.1 Equipment .................................................................